Aug. 31, 2011


A member of the Faculty of 1000 has chosen  Prof. Smadar Cohen’s article Modulation of cardiac macrophages by phosphatidylserine-presenting liposomes improves infarct repair to be included in their library. Inclusion in the library signals that it is in the top 2% of articles published in biology and medicine this year.
The article appeared in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) in February. The article “reports a novel immunomodulatory approach to improve acute myocardial infarction (AMI),” according to Faculty of 1000 member Philippe Saas who selected and evaluated the article.
“This approach is based on phosphatidylserine-expressing liposomes that mimic the anti-inflammatory properties of apoptotic cells. This was demonstrated in a rat model of AMI where these liposomes were infused in the femoral vein. This is an interesting way to treat AMI. This paper illustrates nicely the “dying cell hypothesis,” he wrote.
Prof. Cohen is the incumbent of the Claire & Harold Oshry Chair in Biotechnology in the Avram and Stella Goldstein-Goren Department of Biotechnology Engineering.  She is the former founding chair of the department.
Cohen co-wrote the article with Tamar Harel-Adar, also of the department, as well as Tamar Ben Mordechai, Yoram Amsalem, Micha S. Feinberg, and Jonathan Leor of the Neufeld Cardiac Research Institute, Tel Aviv University, Sheba Medical Center
The Faculty of 1000 comprises a subscription-only database of 100,000 articles evaluated by the Faculty of 10,000 experts, all of whom are highly respected in their field.