Microalgal Biotechnology Laboratory, French Associates Institute for Agriculture & Biotechnology of Drylands, The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Sede -Boqer Campus, Midreshet Ben-Gurion 84990

Tel (office):                   08-656-3478

Tel (lab):                        08-659-6798


Research interests

  1. Biosynthesis, role and biotechnology for LC-PUFA in microalgae.
  2. Genetic transformation and metabolic engineering of model and non-model microalgae for improvement of biotechnology-relevant traits, elucidation of the mechanisms of LC-PUFA and TAG metabolism.
  3. Establishing a high-confidence lipid droplet proteome of the diatom Phaeodactylum tricornutum and functional analysis of LD-associated proteins by CRISPR-CAS9 and overexpression analysis
  4. Crosstalk between autophagy and lipid metabolism in microalgae
  5. Application of microalgae to modulate stress and disease-resistance in fish.


Professional Activities

Member of Editorial Board

Algal research

Biology (MDPI)

Biotechnological Letters

Journal of Applied Phycology


Scientific Publications (since 2016)

h-index 30 (ISI)


  1. Refereed articles in scientific journals

    1. Shemesh Z, Leu S, Khozin-Goldberg I#, Didi-Cohen S, Zarka A, Boussiba S. 2016 Inducible expression of Haematococcus oil globule protein in the diatom Phaeodactylum tricornutum: Association with lipid droplets and enhancement of TAG accumulation under nitrogen starvation. Algal Research 18: 321–331
    2. Kazachkova Y, Khan A, Acuna T, López-Díaz I, Carrera Bergua E, Khozin-Goldberg I, Fait A, Barak S. 2016 Salt Induces Features of a Dormancy-Like State in Seeds of Eutrema (Thellungiella) salsugineum, a Halophytic Relative of Arabidopsis. Frontiers in Plant Science 7:1071
    3. Popko J, Herrfurth C, Feussner K, Ischebeck T, Iven T, Haslam R, Hamilton M, Sayanova O, Napier J, Khozin-Goldberg I, Feussner I. 2016. Metabolome analysis reveals betaine lipids as major source for triglyceride formation, and the accumulation of sedoheptulose during nitrogen-starvation of Phaeodactylum tricornutum. Plos ONE 11(10):e0164673.
    4. Zorin B, Pal-Nath D, Lukyanov A, Smolskaya S, Kolusheva S, Didi-Cohen S, Boussiba S, Cohen Z, Khozin-Goldberg I#, Solovchenko  A (2017) Arachidonic acid is important for efficient light use by the microalga Lobosphaera incisa under chilling stress conditions. Biochim Biophys Acta 1862(9):853-868
    5. Siegler H., Valerius O, Ischebeck T., Popko J, Tourasse N. J., Vallon O., Khozin-Goldberg I, Braus G. H. And Feussner I. Analysis of the lipid body proteome of the oleaginous alga Lobosphaera incisa. BMC Plant Biology (2017) 17:98
    6. Pal-Nath D, Didi-Cohen S, Shtaida N, Nath P R, Samani T, Boussiba S, Khozin-Goldberg I# (2017) Improved productivity and oxidative stress tolerance under nitrogen starvation is associated with the ablated Δ5 desaturation in the green microalga Lobosphaera incisa. Algal Research 26 :25–38
    7. Nayak S, Koven W, Meiri I, Khozin-Goldberg I, Isakov N, Zibdeh M, Zilberg D#. 2017 Dietary arachidonic acid affects immune function and fatty acid composition in cultured rabbitfish Siganus rivulatus. Fish and Shellfish Immunology 68: 46-53
    8. Adler-Agnon (Shemesh) Z, Leu S, Zarka A, Boussiba S, Khozin-Goldberg I #. 2018 Novel promoters for constitutive and inducible expression of transgenes in the diatom Phaeodactylum tricornutum under varied nitrate availability. Journal of Applied Phycology  30: 2763–2772
    9. Sitnik S, Shtaida N, Popko J, Guiheneuf F, Leu S, Feussner I, Boussiba S, Khozin-Goldberg I#. 2018 DGAT1 from the arachidonic acid producing microalga Lobosphaera incisa shows late gene expression under nitrogen starvation and substrate promiscuity in a heterologous system. Journal of Applied Phycology 30: 2773–2791
    10. O. Gorelova; O. Baulina; T. Ismagulova; K. Kokabi; E. Lobakova; I. Selyakh; L. Semenova; O. Chivkunova; O Karpova; P. Scherbakov; I. Khozin-Goldberg; A. Solovchenko. 2018 Ultrastructural manifestations of the stress-induced reduction of the photosynthetic apparatus in a chlorophyte cell. Protoplasma 256(1):261-277
    11. Nayak S, Khozin-Goldberg I#, Cohen G, Zilberg D#. Dietary supplementation with ω6 LC-PUFA-rich algae improves zebrafish immune function and resistance to Streptococcal infection. Frontiers in Immunology doi: 10.3389/fimmu.2018.01960; 2018;
    12. Kugler, B. Zorin, O. Gorelova, M. Sibiryak, S. Didi-Cohen, T. Ismagulova, K. Kokabi, A. Lukyanov, S. Boussiba, A. Solovchenko, I. Khozin-Goldberg#. 2019 Long-Chain polyunsaturated fatty acids in the green microalga Lobosphaera incisa contribute to tolerance to abiotic stresses Plant & Cell Physiology 60(6):1205-1223. doi: 10.1093/pcp/pcz013.
    13. Kokabi Kamilya, Gorelova Olga, Ismagulova Tatiana, Itkin Maxim, Malitsky Sergey, Boussiba Sammy, Solovchenko Alexei, Khozin-Goldberg Inna# 2019 Metabolomic foundation for differential responses of lipid metabolism to nitrogen and phosphorus deprivation in an arachidonic acid-producing green microalga. Plant Science 283:95-115,
    14. Waissman Levy Noga, Leu Stefan, Khozin-Goldberg Inna#, Boussiba Sammy 2019 Manipulation of trophic capacities in Haematococcus pluvialis enables low-light mediated growth on glucose and astaxanthin formation in the dark. Algal Research  40 (2019) 101497
    15. Lazado Carlo C., Nayak Sagar, Khozin-Goldberg Inna and Zilberg Dina 2019 Gut mucosal barrier responds to time-restricted delivery of Lobosphaera incisa-enriched diets in zebrafish (Danio rerio). Fish and Shellfish Immunology
    16. Y. Taparia, A. Zarka, S. Leu, S. Boussiba and I Khozin-Goldberg#. 2019 The development of a novel endogenous selectable marker in the model diatom Phaeodactylum tricornutum. Scientific Reports 9: 8217 (2019) DOI: 10.1038/s41598-019-44710-5
    17. Gallagher, Hayley; Williams, Jessica O; Ferekidis, Nele; Ismail, Alaa; Chan, Yee-Hung; Michael, Daryn R; Guschina, Irina A; Tyrrell, Victoria J; O'Donnell, Valerie B; Harwood, John L; Khozin-Goldberg, Inna; Boussiba, Sammy; Ramji, Dipak P 2019 Dihimo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis. Biochimica et Biophysica Acta. Molecular basis of disease, 1865: 2538-2550

#corresponding author

b) Chapters in books

  1. Khozin-Goldberg I. 2016 Lipid metabolism in microalgae. In: Develop. Applied Phycology, Vol. 6, Michael Borowitzka et al. (Eds): The Physiology of Microalgae, Springer. ISBN 978-3-319-24945-2
  2. Khozin-Goldberg I., Leu S., Boussiba S. 2016 Production of  PUFA by microalgae. In: Lipids in Plant and Algae Development. Y. Li-Beisson and Y. Nakamura (Eds) Springer ISBN 978-3-319-25979-6
  3. Khozin-Goldberg I., and Sayanova O. 2019 Metabolic Engineering and Synthetic Biology Approaches to Enhancing Production of Long-Chain Polyunsaturated Fatty Acids in Microalgae In: “Grand Challenges in Algae Biotechnology" Hallmann, Armin, Rampelotto, Pabulo H. (Eds.) [Springer] ISBN 978-3-030-25233-5 in press