Contact:
French Associates Institute for Agriculture and Biotechnology of Drylands
Jacob Blaustein Institute for Desert Research
BGU, Sede-Boqer 84990, Israel
Telephone: +972-8-6563478
Fax: +972-8-65966742
E-mail: khozin@bgu.ac.il                           

https://orcid.org/0000-0001-8618-0687

https://scholars.bgu.ac.il/display/khozin

https://www.researchgate.net/profile/Inna_Khozin-Goldberg

https://scholar.google.com/citations?user=6b-1qggAAAAJ&hl=en

                                 

Academic Status:

Associate Professor

 

Research interests:

My main interests are lipid biochemistry and metabolic engineering of eukaryotic microalgae for improvement of valuable traits, and understanding of their fundamental biology and response to environment.

Key interests and expertise:
 
o   Elucidation of biosynthesis and developing technology for production of LC-PUFA by microalgae.

o   Genes encoding enzymes of LC-PUFA and lipid biosynthesis in microalgae:  isolation and functional characterization.

o   Genetic transformation and metabolic engineering of model and non-model microalgae for improvement of biotechnology-relevant traits and elucidation of the mechanisms of LC-PUFA and TAG metabolism.

o   Lipid droplet biogenesis in microalgae

  • Dietary supplementation of microalgae-derived LC-PUFA to modulate stress and disease-resistance in fish.

 

Education:

B.Sc./M.Sc. 1975-1981    D. Mendeleyev University of Chemical Technology of Russia                                       Department of Biotechnology, Moscow, Russia

Ph.D.           1981-1986      Moscow State University, Faculty of Biology, Departments of Plant
                                      Physiology and Microbiology, Russia

 

Scientific Publications :

  • SHTAIDA N, KHOZIN-GOLDBERG I#, SOLOVCHENKO A, CHEKANOV K, DIDI-COHEN S, LEU S, COHEN Z, BOUSSIBA S. 2014. Downregulation of a Putative Plastid PDC E1α Subunit Impairs Photosynthetic Activity and Triacylglycerol Accumulation in Nitrogen Starved Photoautotrophic Chlamydomonas reinhardtii. Journal of Experimental Botany 65(22):6563-76.

    ZORIN B, GRUNDMAN O, KHOZIN-GOLDBERG I#, LEU S, SHAPIRA M, KAYE Y, TOURASSE N, VALLON O, AND SAMMY BOUSSIBA. 2014. Development of a Nuclear Transformation System for Oleaginous Green Alga Lobosphaera (Parietochloris) incisa and Genetic Complementation of a Mutant Strain, Deficient in Arachidonic Acid Biosynthesis. PLOS ONE 18;9(8):e105223

    TOURASSE N J, SHTAIDA N, KHOZIN-GOLDBERG I, BOUSSIBA S, VALLON O. 2015. The complete mitochondrial genome sequence of the green microalga Lobosphaera (Parietochloris) incisa reveals a new type of palindromic repetitive repeat. BMC Genomics 16(1):580.

    KAYE Y, GRUNDMAN O, LEU S, ZARKA A, ZORIN B, DIDI-COHEN S, KHOZIN-GOLDBERG I#, BOUSSIBA S. 2015. Metabolic engineering toward enhanced LC-PUFA biosynthesis in Nannochloropsis oceanica: Overexpression of endogenous Δ12 desaturase driven by stress-inducible promoter leads to enhanced deposition of polyunsaturated fatty acids in TAG. Algal Research 11:387–398.

    SHTAIDA N, KHOZIN-GOLDBERG I#, BOUSSIBA S. 2015. The role of pyruvate hub enzymes in supplying carbon precursors for fatty acid synthesis in photosynthetic microalgae. Photosynthesis Research 125(3): 407-422. 

    ISKANDAROV U, SITNIK S, SHTAIDA N, DIDI-COHEN S, LEU S, KHOZIN-GOLDBERG I #, COHEN Z, BOUSSIBA S. 2015. Cloning and characterization of a GPAT-like gene from the microalga Lobosphaera incisa (Trebouxiophyceae): overexpression in Chlamydomonas reinhardtii enhances TAG production. Journal of Applied Phycology 28(2) pp 907–919

    SHEMESH Z, LEU S, KHOZIN-GOLDBERG I #, DIDI-COHEN S, ZARKA A, BOUSSIBA S #. 2016 Inducible expression of Haematococcus oil globule protein in the diatom Phaeodactylum tricornutum: Association with lipid droplets and enhancement of TAG accumulation under nitrogen starvation. Algal Research 18: 321–331

    POPKO J, HERRFURTH C, FEUSSNER K, ISCHEBECK T, IVEN T, HASLAM R, HAMILTON M, SAYANOVA O, NAPIER J, KHOZIN-GOLDBERG I, FEUSSNER I 2016. Metabolome analysis reveals betaine lipids as major source for triglyceride formation, and the accumulation of sedoheptulose during nitrogen-starvation of Phaeodactylum tricornutum. Plos ONE 11(10):e0164673. doi: 10.1371/journal.pone.0164673.

    ZORIN B, PAL-NATH D, LUKYANOV A, SMOLSKAYA S, KOLUSHEVA S, DIDI-COHEN S, BOUSSIBA S, COHEN Z, KHOZIN-GOLDBERG I #, SOLOVCHENKO  A 2017 Arachidonic acid is important for efficient light use by the microalga Lobosphaera incisa under chilling stress conditions. Biochim Biophys Acta 1862(9):853-868

    SIEGLER H., VALERIUS O, ISCHEBECK T., POPKO J, TOURASSE N. J., VALLON O., KHOZIN-GOLDBERG I, BRAUS G. H. and FEUSSNER I. Analysis of the lipid body proteome of the oleaginous alga Lobosphaera incisa. BMC Plant Biology (2017) 17:98

    PAL-NATH D, DIDI-COHEN S, NASTASSIA SHTAIDA, PULAK RANJAN NATH, TALYA SAMANI, S BOUSSIBA, KHOZIN-GOLDBERG I# 2017 Improved productivity and oxidative stress tolerance under nitrogen starvation is associated with the ablated Δ5 desaturation in the green microalga Lobosphaera incisa. Algal Research 26 :25–38

    # corresponding author;

    h-index (WOS): 26

     

    Selected book chapters

    Khozin-Goldberg I. Lipid metabolism in microalgae. In: Develop. Applied Phycology, Vol. 6, Michael Borowitzka et al. (Eds): The Physiology of Microalgae, Springer. ISBN 978-3-319-24945-2

    Khozin-Goldberg I., Leu S., Boussiba S. Production of  PUFA by microalgae. In: Lipids in Plant and Algae Development. Y. Li-Beisson and Y. Nakamura (Eds) Springer ISBN 978-3-319-25979-6

     

    Supervision of research students (graduation year)

    2005    P. Shrestha, PhD, BGU (jointly with Prof. Z. Cohen) (at present Senior Researcher at The Commonwealth Scientific and Industrial Research Organisation, Canberra, Australia).

    2005    D. Cohen, M.Sc., Dep. of Chemistry, BGU (jointly with Prof. Z. Cohen).

    2005    D. Shuuluka, M. Sc., University of Namibia (jointly with Prof. Z. Cohen and Dr. M. Kandawa-Schultz).

    2006    M. Cohen, M.Sc., A. Katz International School for Desert Studies, BGU (jointly with Prof. Z. Cohen).

    2007    A. Dagar, M. Sc., A. Katz International School for Desert Studies, BGU (jointly with Prof. Z. Cohen and Dr. D. Zilberg).

    2007    S. Abu-Gosh, M. Sc., A. Katz International School for Desert Studies, BGU (jointly with Prof. Z. Cohen)

    2008    D. Martkovitch, M. Sc., A. Katz International School for Desert Studies, BGU (jointly with Prof. Z. Cohen)

    2008    P. Nath, M. Sc., A. Katz International School for Desert Studies, BGU (jointly with Prof. Z. Cohen and Dr. D. Zilberg) (at present Post-Doctoral Fellow at NIH).

    2009    S. Smolskaya, M. Sc., A. Katz International School for Desert Studies, (jointly with Prof. Z. Cohen)

    2010    U. Iskandarov, PhD, BGU (jointly with Prof. Z. Cohen) (at present Post-Doctoral Fellow at Department of Biochemistry & Center for Plant Science Innovation University of Nebraska-Lincoln)

    2010    D. Pal, M. Sc., BGU, A. Katz International School for Desert Studies (jointly with Prof. Z. Cohen)

    2012    S. Sitnik, M. Sc., BGU, A. Katz International School for Desert Studies (jointly with Prof. S. Boussiba) (at present Post-Doctoral Fellow at Westfälische Wilhelms-Universität, Institute of Virology Münster, Germany.

    2014    N. Shtaida, PhD, BGU( jointly with Prof. Z. Cohen, Prof. Sammy Boussiba) (at present Post-Doctoral Fellow at Tartu University, Estonia)

    2014    O. Grundman, combined PhD, BGU, (jointly with Prof. Z. Cohen, Prof. M. Shapira, Prof. D. Raveh, Prof. S. Boussiba) (at present Senior R&D manager Algotechnologies)

    2014    E. Maimon, M. Sc., A. Katz International School for Desert Studies (jointly with Prof. S. Boussiba)

    2015    D. Pal, PhD, BGU (jointly with Prof. S. Boussiba; scientific adviser Prof. Z. Cohen))

    2015    Z. Shemesh, PhD, BGU (jointly with Prof. S. Boussiba)

    2014    Yang Rongzhi, M. Sc., A. Katz International School for Desert Studies (jointly with Prof. S. Boussiba)

    2017    Isabel Portugal, PhD, BGU (jointly with Prof. S. Boussiba and Dr. Dina Zilberg)

    2018    Idan Korin, PhD candidate, BGU (jointly with Prof. S. Boussiba)

    Present            Amit Kugler, M. Sc., A. Katz International School for Desert Studies

    Present            Amir Levy, M. Sc., A. Katz International School for Desert Studies (jointly with Prof. S. Boussiba and Dr. A. Zarka)

    Present            Kamila Kokabi, PhD candidate, BGU (jointly with Prof. S. Boussiba)

    Present            Noga Levy, PhD candidate, BGU (jointly with Prof. S. Boussiba)

    Present            Yogesh Taparia, PhD candidate, BGU (jointly with Prof. S. Boussiba)

    Present            Ben Leyland PhD candidate (combined track) BGU (jointly with Prof. S. Boussiba)

    Present            Ekaterina Novichkova, PhD candidate, BGU, (jointly with Prof. S. Boussiba and Prof. J. Gophas)

    Present            Anna Sherman, PhD candidate, BGU (jointly with Prof. S. Boussiba)

    Present            Dr. Puja Kumari , Post-Doctoral fellow