​My ORCID: https://orcid.org/0000-0001-8618-0687

My ResearchGate profile:https://www.researchgate.net/profile/Inna_Khozin-Goldberg

My Google scholar profile: https://scholar.google.com/citations?user=6b-1qggAAAAJ&hl=en

My Publons profile: https://publons.com/researcher/900151/inna-khozin-goldberg/



Microalgal Biotechnology Laboratory, French Associates Institute for Agriculture & Biotechnology of Drylands, The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev

​Tel (office):                   08-656-3478

Tel (lab):                        08-659-6798

e-mail: khozin@bgu.ac.il

Academic Status:

Full Professor

Research interests

o   Biosynthesis, role and biotechnology for LC-PUFA in microalgae.

o   Genetic transformation and metabolic engineering of model and non-model microalgae; LC-PUFA and TAG metabolism.

o   Lipid droplet proteome of the diatom Phaeodactylum tricornutum and functional analysis of LD-  associated proteins by CRISPR-Cas9 and overexpression analysis

o   Crosstalk between autophagy and lipid metabolism in microalgae

o   Metabolomics and lipidomic in microalgae under environmental stresses

o   Dietary applications of microalgae to modulate stress and disease-resistance in fish

o   Cyanophycin formation in diazotrophic cyanobacteria

o   Anti-inflammatory activities of omega-6 LC-PUFA, DGLA

​Professional Activities

Member of Editorial Board

Algal research

Biology (MDPI)

Journal of Applied Phycology

Biotechnological Letters

Scientific Publications (since 2016)

h-index 34 (ISI)

Refereed articles in scientific journals

  1. Shemesh Z, Leu S, Khozin-Goldberg I#, Didi-Cohen S, Zarka A, Boussiba S. 2016 Inducible expression of Haematococcus oil globule protein in the diatom Phaeodactylum tricornutum: Association with lipid droplets and enhancement of TAG accumulation under nitrogen starvation. Algal Research 18: 321–331
  2. Kazachkova Y, Khan A, Acuna T, López-Díaz I, Carrera Bergua E, Khozin-Goldberg I, Fait A, Barak S. 2016 Salt Induces Features of a Dormancy-Like State in Seeds of Eutrema (Thellungiella) salsugineum, a Halophytic Relative of Arabidopsis. Frontiers in Plant Science 7:1071
  3. Popko J, Herrfurth C, Feussner K, Ischebeck T, Iven T, Haslam R, Hamilton M, Sayanova O, Napier J, Khozin-Goldberg I, Feussner I. 2016. Metabolome analysis reveals betaine lipids as major source for triglyceride formation, and the accumulation of sedoheptulose during nitrogen-starvation of Phaeodactylum tricornutum. Plos ONE 11(10):e0164673.
  4. Zorin B, Pal-Nath D, Lukyanov A, Smolskaya S, Kolusheva S, Didi-Cohen S, Boussiba S, Cohen Z, Khozin-Goldberg I#, Solovchenko  A (2017) Arachidonic acid is important for efficient light use by the microalga Lobosphaera incisa under chilling stress conditions. Biochim Biophys Acta 1862(9):853-868
  5. Siegler H., Valerius O, Ischebeck T., Popko J, Tourasse N. J., Vallon O., Khozin-Goldberg I, Braus G. H. And Feussner I. Analysis of the lipid body proteome of the oleaginous alga Lobosphaera incisa. BMC Plant Biology (2017) 17:98
  6. Pal-Nath D, Didi-Cohen S, Shtaida N, Nath P R, Samani T, Boussiba S, Khozin-Goldberg I (2017) Improved productivity and oxidative stress tolerance under nitrogen starvation is associated with the ablated Δ5 desaturation in the green microalga Lobosphaera incisa. Algal Research 26 :25–38
  7. Nayak S, Koven W, Meiri I, Khozin-Goldberg I, Isakov N, Zibdeh M, Zilberg D. 2017 Dietary arachidonic acid affects immune function and fatty acid composition in cultured rabbitfish Siganus rivulatus. Fish and Shellfish Immunology 68: 46-53
  8. Adler-Agnon (Shemesh) Z, Leu S, Zarka A, Boussiba S, Khozin-Goldberg I. 2018 Novel promoters for constitutive and inducible expression of transgenes in the diatom Phaeodactylum tricornutum under varied nitrate availability. Journal of Applied Phycology 30: 2763–2772
  9. Sitnik S, Shtaida N, Popko J, Guiheneuf F, Leu S, Feussner I, Boussiba S, Khozin-Goldberg I. 2018 DGAT1 from the arachidonic acid producing microalga Lobosphaera incisa shows late gene expression under nitrogen starvation and substrate promiscuity in a heterologous system. Journal of Applied Phycology 30: 2773–2791
  1. O. Gorelova; O. Baulina; T. Ismagulova; K. Kokabi; E. Lobakova; I. Selyakh; L. Semenova; O. Chivkunova; O Karpova; P. Scherbakov; I. Khozin-Goldberg; A. Solovchenko. 2018 Ultrastructural manifestations of the stress-induced reduction of the photosynthetic apparatus in a chlorophyte cell. Protoplasma 256(1):261-277
  2. Nayak S, Khozin-Goldberg I#, Cohen G, Zilberg D#. 2018 Dietary supplementation with ω6 LC-PUFA-rich algae improves zebrafish immune function and resistance to Streptococcal infection. Frontiers in Immunology doi: 10.3389/fimmu.2018.01960
  3. Kugler, B. Zorin, O. Gorelova, M. Sibiryak, S. Didi-Cohen, T. Ismagulova, K. Kokabi, A. Lukyanov, S. Boussiba, A. Solovchenko, I. Khozin-Goldberg. 2019 Long-Chain polyunsaturated fatty acids in the green microalga Lobosphaera incisa contribute to tolerance to abiotic stresses Plant & Cell Physiology 60(6):1205-1223. doi: 10.1093/pcp/pcz013.
  4. Kokabi Kamilya, Gorelova Olga, Ismagulova Tatiana, Itkin Maxim, Malitsky Sergey, Boussiba Sammy, Solovchenko Alexei, Khozin-Goldberg Inna 2019 Metabolomic foundation for differential responses of lipid metabolism to nitrogen and phosphorus deprivation in an arachidonic acid-producing green microalga. Plant Science 283:95-115,
  5. Waissman Levy Noga, Leu Stefan, Khozin-Goldberg Inna#, Boussiba Sammy 2019 Manipulation of trophic capacities in Haematococcus pluvialis enables low-light mediated growth on glucose and astaxanthin formation in the dark. Algal Research 40 (2019) 101497
  6. Lazado Carlo C., Nayak Sagar, Khozin-Goldberg Inna and Zilberg Dina 2019 Gut mucosal barrier responds to time-restricted delivery of Lobosphaera incisa-enriched diets in zebrafish (Danio rerio). Fish and Shellfish Immunology  89:368-377. doi: 10.1016/j.fsi.2019.04.012.
  1. Y. Taparia, A. Zarka, S. Leu, S. Boussiba and I Khozin-Goldberg. 2019 The development of a novel endogenous selectable marker in the model diatom Phaeodactylum tricornutum. Scientific Reports 9: 8217 (2019) DOI: 10.1038/s41598-019-44710-5
  2. Gallagher, Hayley; Williams, Jessica O; Ferekidis, Nele; Ismail, Alaa; Chan, Yee-Hung; Michael, Daryn R; Guschina, Irina A; Tyrrell, Victoria J; O'Donnell, Valerie B; Harwood, John L; Khozin-Goldberg, Inna; Boussiba, Sammy; Ramji, Dipak P 2019 Dihimo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis. Biochimica et Biophysica Acta. Molecular basis of disease, 1865: 2538-2550
  3. Solovchenko, I. Khozin-Goldberg, I. Selyakh, L. Semenova, T. Ismagulova, A. Lukyanov, I. Mamedov, E. Vinogradova, O. Karpova, I. Konyukhov, S. Vasilieva, P. Mojzes, C. Dijkema, M. Vecherskaya, I. Zvyagin, L. Nedbal, O. Gorelova. (2019) Phosphorus starvation and luxury uptake in green microalgae revisited. Algal Research 43:101651
  4. Kugler, A; Kumari, P; Kokabi, K; Itkin, M; Malitsky, S; Khozin-Goldberg, I (2020) Resilience to freezing in the vegetative cells of the green microalga Lobosphaera incisa. Journal of Phycology, 56, 334–345
  5. Ben Leyland, Sammy Boussiba, Inna Khozin-Goldberg (2020) A review of diatom lipid droplets. Biology (This article belongs to the Special Issue “The Molecular Life of Diatoms: From Genes to Ecosystems") 9(2), 38; https://doi.org/10.3390/biology9020038
  6. P. Kumari, A. Cna'ani, S. Didi-Cohen, V. Tzin, I. Khozin-Goldberg (2020)  Nitrogen deprivation-induced production of volatile organic compounds in the arachidonic-acid-accumulating microalga Lobosphaera incisa underpins their role as ROS scavengers and chemical messengers. Frontiers in Marine Science Manuscript ID: 547633 https://www.frontiersin.org/articles/10.3389/fmars.2020.00410/full
  7. S. Nayak, A. Al Ashhab, D. Zilberg, I. Khozin-Goldberg.  (2020) Dietary supplementation with omega-6 LC-PUFA rich microalgae regulates mucosal immune response and promotes microbial diversity in the zebrafish gut, Biology 9(6), 119; https://doi.org/10.3390/biology9060119
  8. B. Leyland, A. Zarka, S. Boussiba, I. Khozin-Goldberg. (2020) High resolution proteome of lipid droplets isolated from the pennate diatom Phaeodactylum tricornutum ( Bacillariophyceae ) strain Pt4 provides mechanistic insights into complex intracellular coordination during nitrogen deprivation. Journal of Phycology. 56: 1642-1663 https://onlinelibrary.wiley.com/doi/abs/10.1111/jpy.13063
  9. E. Novichkova, K. Tzumin, N. Eretz-Kdosha, S. Boussiba, J. Gopas, G. Cohen, I. Khozin-Goldberg. (2020) DGLA from the microalga Lobosphaera incisa P127 modulates prostaglandin production, inhibits iNOS expression and alleviates NO secretion in liposaccharide-induced murine RAW264.7 macrophages Nutrients 12, 2892 22;12(9):2892. doi: 10.3390/nu12092892.
  10. K. Kokabi, O. Gorelova, B. Zorin, M. Itkin, S. Malitsky, A. Solovchenko, S. Boussiba, I. Khozin-Goldberg.  (2020) Lipidome remodeling and autophagic repose in the arachidonic-acid-rich microalga Lobosphaera incisa under Nitrogen and Phosphorous deprivation. Frontiers in Plant Science. 11:614846 doi: 10.3389/fpls.2020.614846
  11. I. Koren, S. Boussiba, I. Khozin-Goldberg, A. Zarka (2021) Chromochloris  zofingiensis    (Chlorophyceae) divides by consecutive multiple fission cell-cycle under batch and continuous cultivation. Biology 10(2), 157 (This article belongs to a special issue “The Path to Sustainable Production and Application of Algae") https://doi.org/10.3390/biology10020157


Chapters in books

  1. Khozin-Goldberg I. 2016 Lipid metabolism in microalgae. In: Develop. Applied Phycology, Vol. 6, Michael Borowitzka et al. (Eds): The Physiology of Microalgae, Springer. ISBN 978-3-319-24945-2
  2. Khozin-Goldberg I., Leu S., Boussiba S. 2016 Production of PUFA by microalgae. In: Lipids in Plant and Algae Development. Y. Li-Beisson and Y. Nakamura (Eds) Springer ISBN 978-3-319-25979-6
  3. Khozin-Goldberg I., and Sayanova O. 2019 Metabolic Engineering and Synthetic Biology Approaches to Enhancing Production of Long-Chain Polyunsaturated Fatty Acids in Microalgae In: “Grand Challenges in Algae Biotechnology" Hallmann, Armin, Rampelotto, Pabulo H. (Eds.) [Springer] https://link.springer.com/chapter/10.1007/978-3-030-25233-5_7