Nava Issacharoff Rubenzadeh was born in Jerusalem to an immigrant family from Bukhara, years before the creation of the State of Israel. After finishing her studies in education and serving in the army, she worked with Olim (immigrants). ​These experiences of her youth would mark her for life, drive her actions up to this day.  

After she married her husband Daniel, they started their family in Argentina. They had two children, Ariel z"l and Shiri, and two granddaughters, Keila and Mila.

Nava is co-founder of the Argentine Women's Division of CUJA, created in 1978, and was its President for several periods. She was also International Vice President of Keren Hayesod's Women's Division until she was appointed International President, a position she held from 1998 to 2003. She also served on the Board and was Governor of the Jewish Agency until 2003. One of the keystone projects led by Nava is the Branco Weiss Beit Ariel school for at-risk teens in Beer-Sheva, in memory of her son Ariel z"l.

Nava has been President of the Argentine Friends of Ben Gurion University Since 2005, developing several projects, and is also a member of its Board of Governors.

Nava has received many honors in recognition of her work. In Argentina: the Golda Meir Award for her community involvement, the AMIA Award for her commitment to Aliyah, and the CUJA Award for her career. The Minister of Education of the Republic of Argentina recently cited her for her contribution to the friendship between Israel and Argentina, and the Keren Hayesod recognized her on several occasions, as World President, as a symbol of the Lions of Judea and with the Award of Excellence of the Women's Divisions.​ Ben-Gurion University also honored her with the Ben-Gurion Award for her contribution to the development of the Negev.  ​​