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Imaging Blood-Brain Barrier Dysfunction in Drug-Resistant Epilepsy: A Multi-Center Feasibility Study
Cafri N, Mirloo S, Zarhin D, Kamintsky L, Serlin Y, Alhadeed L, Goldberg I, Maclean MA, Whatley B, Urman I, Doherty CP, Greene C, Behan C, Brennan D, Campbell M, Bowen C, Ben-Arie G, Shelef I, Wandschneider B, Koepp M, Friedman A and Benninger F.
Epilepsia in-press 2024
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Artificial intelligence-based extraction of quantitative ultra-widefield fluorescein angiography parameters in retinal vein occlusion.
Huang RS, Mihalache A, Popovic MM, Munn C, Melo IM, Pecaku A, Kamintsky L, Friedman A, Wong DT, Muni RH.
Canadian Journal of Ophthalmology, Volume 0, Issue 0. doi: 10.1016/j.jcjo.2024.08.002.
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Interictal blood-brain barrier dysfunction in piriform cortex of people with epilepsy.
Schulte F, Reiter JT, Bauer T, Taube J, Bitzer F, Witt JA, Piper R, Thanabalasingam A, von Wrede R, Racz A, Baumgartner T, Borger V, Specht-Riemenschneider L, Vatter H, Hattingen E, Deichmann R, Helmstaedter C, Radbruch A,Friedman A, Surges R, Rüber T.
Ann Clin Transl Neurol. 2024 Aug 27. doi: 10.1002/acn3.52176. Online ahead of print.PMID: 39190772.
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ASSOCIATION OF INTRAVENOUS FLUORESCEIN ANGIOGRAPHY AND ADAPTIVE OPTICS IMAGING IN DIABETIC RETINOPATHY: A Prospective Case Series.
Huang RS, Mihalache A, Popovic MM, Munn C, Balas M, Issa M, Melo IM, Friedman A, Wright T, Yan P, Muni RH.
Retina. 2024 Apr 1;44(4):689-699. doi: 10.1097/IAE.0000000000004012.
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Artificial intelligence-enhanced analysis of retinal vasculature in age-related macular degeneration.
Huang RS, Mihalache A, Popovic MM, Munn C, Melo IM, Pecaku A, Friedman A, Wong DT, Muni RH.
Retina. 2024 Sep 1;44(9):1478-1485. doi: 10.1097/IAE.0000000000004159.PMID: 39167569
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Cortical plasticity is associated with blood-brain barrier modulation.
Swissa E, Monsonego U, Yang LT, Schori L, Kamintsky L, Mirloo S, Burger I, Uzzan S, Patel R, Sudmant PH, Prager O, Kaufer D, Friedman A.
Elife. 2024 Jul 18;12:RP89611. doi: 10.7554/eLife.89611.PMID: 39024007.
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From spreading depolarization to blood-brain barrier dysfunction: navigating traumatic brain injury for novel diagnosis and therapy.
van Hameren G, Aboghazleh R, Parker E, Dreier JP, Kaufer D, Friedman A.
Nat Rev Neurol. 2024 Jul;20(7):408-425. doi: 10.1038/s41582-024-00973-9. Epub 2024 Jun 17.PMID: 38886512.
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Blood-brain barrier dysfunction and decreased transcription of tight junction proteins in epileptic dogs.
Hanael E, Baruch S, Altman RK, Chai O, Rapoport K, Peery D, Friedman A, Shamir MH.
J Vet Intern Med. 2024 Jul-Aug;38(4):2237-2248. doi: 10.1111/jvim.17099. Epub 2024 Jun 6.PMID: 38842297.
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Contrast-Induced Encephalopathy and the Blood-Brain Barrier.
Maclean MA, Rogers PS, Muradov JH, Pickett GE,Friedman A, Weeks A, Greene R, Volders D.
Can J Neurol Sci. 2024 Mar 8:1-10. doi: 10.1017/cjn.2024.38. Online ahead of print.PMID: 38453685
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Evidence for interictal blood-brain barrier dysfunction in people with epilepsy.
Reiter JT, Schulte F, Bauer T, David B, Endler C, Isaak A, Schuch F, Bitzer F, Witt JA, Hattingen E, Deichmann R, Attenberger U, Becker AJ, Helmstaedter C, Radbruch A, Surges R,Friedman A.
Epilepsia. 2024 May;65(5):1462-1474. doi: 10.1111/epi.17929. Epub 2024 Mar 4.
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Atypical paroxysmal slow cortical activity in healthy adults: Relationship to age and cognitive performance.
Power L, Friedman A, Bardouille T.
Neurobiol Aging. 2024 Jan 26;136:44-57. doi: 10.1016/j.neurobiolaging.2024.01.009.
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Mechanisms of blood-retinal barrier disruption related to intraocular inflammation and malignancy.
Tomkins-Netzer O, Niederer R, Greenwood J, Fabian ID, Serlin Y, Friedman A, Lightman S.
Prog Retin Eye Res. 2024 Jan 17;99:101245. doi: 10.1016/j.preteyeres.2024.101245..
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Memantine inhibits cortical spreading depolarization and improves neurovascular function following repetitive traumatic brain injury.
MacLean MA, Muradov JH, Greene R, Van Hameren G, Clarke DB, Dreier JP, Okonkwo DO, Friedman A.
Sci Adv. 2023 Dec 15;9(50):eadj2417. doi: 10.1126/sciadv.adj2417
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Clinical characteristics and outcomes of patients with post-stroke epilepsy: protocol for an individual patient data meta-analysis from the International Post-stroke Epilepsy Research Repository (IPSERR).
Mishra NK, Kwan P, Tanaka T, Sunnerhagen KS, Dawson J, Zhao Y, Misra S, Wang S, Sharma VK, Mazumder R, Funaro MC, Ihara M, Nicolo JP, Liebeskind DS, Yasuda CL, Cendes F, Quinn TJ, Ge Z, Scalzo F, Zelano J, Kasner SE; International Post-Stroke Epilepsy Research Consortium (IPSERC);
BMJ Open. 2023 Nov 15;13(11):e078684. doi: 10.1136/bmjopen-2023-078684.
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Mitochondrial dysfunction underlies impaired neurovascular coupling following traumatic brain injury.
van Hameren G, Muradov J, Minarik A, Aboghazleh R, Orr S, Cort S, Andrews K, McKenna C, Pham NT, MacLean MA, Friedman A.
Neurobiol Dis. 2023 Oct 1;186:106269. doi: 10.1016/j.nbd.2023.106269
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Blood-Brain Barrier Dysfunction and Exposure to Head Impacts in University Football Players.
Jones CMA, Kamintsky L, Parker E, Kureshi N, Audas L, Wilson L, Champagne AA, Boulanger MM, DiStefano V, Fenerty L, Bowen C, Beyea S, Atkinson C, Clarke DB, Friedman A.
Clin J Sport Med. 2024 Jan 1;34(1):61-68. doi: 10.1097/JSM.0000000000001164
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Deep Isoflurane Anesthesia Is Associated with Alterations in Ion Homeostasis and Specific Na+/K+-ATPase Impairment in the Rat Brain.
Reiffurth C, Berndt N, Gonzalez Lopez A, Schoknecht K, Kovács R, Maechler M, Grote Lambers M, Dreier JP, Friedman A, Spies C, Liotta A.
Anesthesiology. 2023 Jun 1;138(6):611-623. doi: 10.1097/ALN.0000000000004553.
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Quantitative analysis of magnetic resonance images for characterization of blood-brain barrier dysfunction in dogs with brain tumors.
Hanael E, Baruch S, Chai O, Lishitsky L, Blum T, Rapoport K, Ruggeri M, Aizenberg Z, Peery D, Meyerhoff N, Volk HA, De Decker S, Tipold A, Baumgaertner W, Friedman A, Shamir M.
J Vet Intern Med. 2023 Mar;37(2):606-617. doi: 10.1111/jvim.16654. Epub 2023 Feb 27.
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White-matter correlates of anxiety: The contribution of the corpus-callosum to the study of anxiety and stress-related disorders.
Saar-Ashkenazy R, Guez J, Jacob Y, Veksler R, Cohen JE, Shelef I, Friedman A, Benifla M.
Int J Methods Psychiatr Res. 2022 Nov 29:e1955. doi: 10.1002/mpr.1955. Online ahead of print.
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Stroke-prone salt-sensitive spontaneously hypertensive rats show higher susceptibility to spreading depolarization (SD) and altered hemodynamic responses to SD.
Kang EJ, Prager O, Lublinsky S, Oliveira-Ferreira AI, Reiffurth C, Major S, Müller DN, Friedman A, Dreier JP.
J Cereb Blood Flow Metab. 2023 Feb;43(2):210-230. doi: 10.1177/0271678X221135085. Epub 2022 Nov 3.
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A companion to the preclinical common data elements and case report forms for in vivo rodent neuroimaging: A report of the TASK3-WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force.
van Vliet EA, Immonen R, Prager O, Friedman A, Bankstahl JP, Wright DK, O'Brien TJ, Potschka H, Gröhn O, Harris NG.
Epilepsia Open. 2022 Aug 13. doi: 10.1002/epi4.12643. Online ahead of print.
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Role of autoantibodies and blood-brain barrier leakage in cognitive impairment in systemic lupus erythematosus.
Hanly JG, Legge A, Kamintsky L, Friedman A, Hashmi JA, Beyea SD, Fisk J, Omisade A, Calkin C, Bardouille T, Bowen C, Matheson K, Fritzler MJ.
Lupus Sci Med. 2022 Jun;9(1):e000668. doi: 10.1136/lupus-2022-000668.
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Resting state functional connectivity in SLE patients and association with cognitive impairment and blood-brain barrier permeability.
Hanly JG, Robertson JW, Legge A, Kamintsky L, Aristi G, Friedman A, Beyea SD, Fisk JD, Omisade A, Calkin C, Bardouille T, Bowen C, Matheson K, Hashmi JA.
Rheumatology (Oxford). 2023 Feb 1;62(2):685-695. doi: 10.1093/rheumatology/keac343.
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A fluorescein angiography-based computer-aided algorithm for assessing the retinal vasculature in diabetic retinopathy.
Abbasnejad A, Tomkins-Netzer O, Winter A, Friedman A, Cruess A, Serlin Y, Levy J.
Eye (Lond). 2023 May;37(7):1293-1301. doi: 10.1038/s41433-022-02120-4. Epub 2022 May 28.
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Symptoms reported by Canadians posted in Havana are linked with reduced white matter fibre density.
Aristi G, Kamintsky L, Ross M, Bowen C, Calkin C, Friedman A, Hashmi JA.
Brain Commun. 2022 Mar 7;4(2):fcac053. doi: 10.1093/braincomms/fcac053. eCollection 2022.
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Craniotomy for acute monitoring of pial vessels in the rodent brain.
Aboghazleh R, Alkahmous B, Swissa E, Mansoor S, Friedman A, Prager O.
MethodsX. 2022 Apr 8;9:101694. doi: 10.1016/j.mex.2022.101694. eCollection 2022.
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Spreading depolarizations in ischaemia after subarachnoid haemorrhage, a diagnostic phase III study.
Dreier JP, Winkler MKL, Major S, Horst V, Lublinsky S, Kola V, Lemale CL, Kang EJ, Maslarova A, Salur I, Lückl J, Platz J, Jorks D, Oliveira-Ferreira AI, Schoknecht K, Reiffurth C, Milakara D, Wiesenthal D, Hecht N, Dengler NF, Liotta A, Wolf S, Kowoll CM, Schulte AP, Santos E, Güresir E, Unterberg AW, Sarrafzadeh A, Sakowitz OW, Vatter H, Reiner M, Brinker G, Dohmen C, Shelef I, Bohner G, Scheel M, Vajkoczy P, Hartings JA, Friedman A, Martus P, Woitzik J.
Brain. 2022 May 24;145(4):1264-1284. doi: 10.1093/brain/awab457.
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Detection of blood-brain barrier dysfunction using advanced imaging methods to predict seizures in dogs with meningoencephalitis of unknown origin.
Hanael E, Baruch S, Chai O, Nir Z, Rapoport K, Ruggeri M, Eizenberg I, Peery D, Friedman A, Shamir MH.
J Vet Intern Med. 2022 Mar;36(2):702-712. doi: 10.1111/jvim.16396. Epub 2022 Mar 14.
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Reversal of insulin resistance is associated with repair of blood-brain barrier dysfunction and remission in a patient with treatment-resistant bipolar depression.
Calkin C, Kamintsky L, Friedman A.
Bipolar Disord. 2022 Aug;24(5):553-555. doi: 10.1111/bdi.13199. Epub 2022 Mar 13.
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Telmisartan as an add-on treatment for dogs with refractory idiopathic epilepsy: a nonrandomized, uncontrolled, open-label clinical trial.
Hanael E, Chai O, Konstanitin L, Gibeon L, Rapaport K, Ruggeri M, Friedman A, Shamir MH.
J Am Vet Med Assoc. 2022 Feb 24;260(7):735-740. doi: 10.2460/javma.20.12.0683.
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The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS).
Kaplan A, Zelicha H, Yaskolka Meir A, Rinott E, Tsaban G, Levakov G, Prager O, Salti M, Yovell Y, Ofer J, Huhn S, Beyer F, Witte V, Villringer A, Meiran N, B Emesh T, Kovacs P, von Bergen M, Ceglarek U, Blüher M, Stumvoll M, Hu FB, Stampfer MJ, Friedman A, Shelef I, Avidan G, Shai I.
Am J Clin Nutr. 2022 May 1;115(5):1270-1281. doi: 10.1093/ajcn/nqac001.
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International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke.
Mishra NK, Engel J Jr, Liebeskind DS, Sharma VK, Hirsch LJ, Kasner SE, French JA, Devinsky O, Friedman A, Dawson J, Quinn TJ, Selim M, de Havenon A, Yasuda CL, Cendes F, Benninger F, Zaveri HP, Burneo JG, Srivastava P, Bhushan Singh M, Bhatia R, Vishnu VY, Bentes C, Ferro J, Weiss S, Sivaraju A, Kim JA, Galovic M, Gilmore EJ, Pitkänen A, Davis K, Sansing LH, Sheth KN, Paz JT, Singh A, Sheth S, Worrall BB, Grotta JC, Casillas-Espinos PM, Chen Z, Nicolo JP, Yan B, Kwan P; for International Post Stroke Epilepsy Research Consortium (IPSERC).
Epilepsy Behav. 2022 Feb;127:108502. doi: 10.1016/j.yebeh.2021.108502. Epub 2021 Dec 27.
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Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction.
Parker E, Aboghazleh R, Mumby G, Veksler R, Ofer J, Newton J, Smith R, Kamintsky L, Jones CMA, O'Keeffe E, Kelly E, Doelle K, Roach I, Yang LT, Moradi P, Lin JM, Gleason AJ, Atkinson C, Bowen C, Brewer KD, Doherty CP, Campbell M, Clarke DB, van Hameren G, Kaufer D, Friedman A.
Brain. 2022 Jun 30;145(6):2049-2063. doi: 10.1093/brain/awab450.
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Brainstem and Cortical Spreading Depolarization in a Closed Head Injury Rat Model.
Aboghazleh R, Parker E, Yang LT, Kaufer D, Dreier JP, Friedman A, van Hameren G.
Int J Mol Sci. 2021 Oct 28;22(21):11642. doi: 10.3390/ijms222111642.
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Paroxysmal slow wave events predict epilepsy following a first seizure.
Zelig D, Goldberg I, Shor O, Ben Dor S, Yaniv-Rosenfeld A, Milikovsky DZ, Ofer J, Imtiaz H, Friedman A, Benninger F.
Epilepsia. 2022 Jan;63(1):190-198. doi: 10.1111/epi.17110. Epub 2021 Nov 9.
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Insulin Resistance and Blood-Brain Barrier Dysfunction Underlie Neuroprogression in Bipolar Disorder.
Calkin C, McClelland C, Cairns K, Kamintsky L, Friedman A.
Front Psychiatry. 2021 May 25;12:636174. doi: 10.3389/fpsyt.2021.636174. eCollection 2021.
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Response to: 'Correspondence on 'Blood-brain barrier leakage in systemic lupus erythematosus is associated with gray matter loss and cognitive impairment'' by Pamuk and Hasni.
Kamintsky L, Beyea SD, Fisk JD, Hashmi JA, Omisade A, Calkin C, Bardouille T, Bowen C, Quraan M, Mitnitski A, Matheson K, Friedman A, Hanly JG.
Ann Rheum Dis. 2023 May;82(5):e124. doi: 10.1136/annrheumdis-2021-220057. Epub 2021 Feb 23.
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Distorted Optic Nerve Portends Neurological Complications in Infants With External Hydrocephalus.
Serlin Y, Ben-Arie G, Lublinsky S, Flusser H, Friedman A, Shelef I.
Front Neurol. 2021 Feb 1;12:596294. doi: 10.3389/fneur.2021.596294. eCollection 2021.
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TMS-Induced Controlled BBB Opening: Preclinical Characterization and Implications for Treatment of Brain Cancer.
Vazana U, Schori L, Monsonego U, Swissa E, Pell GS, Roth Y, Brodt P, Friedman A, Prager O.
Pharmaceutics. 2020 Oct 5;12(10):946. doi: 10.3390/pharmaceutics12100946.
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Blood-brain barrier leakage in systemic lupus erythematosus is associated with gray matter loss and cognitive impairment.
Kamintsky L, Beyea SD, Fisk JD, Hashmi JA, Omisade A, Calkin C, Bardouille T, Bowen C, Quraan M, Mitnitski A, Matheson K, Friedman A, Hanly JG.
Ann Rheum Dis. 2020 Dec;79(12):1580-1587. doi: 10.1136/annrheumdis-2020-218004. Epub 2020 Oct 1.
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Dual-Targeted Autoimmune Sword in Fatal Epilepsy: Patient's glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce Reactive Oxygen Species (ROS) in, and kill both human neural cells and T cells.
Levite M, Zelig D, Friedman A, Ilouz N, Eilam R, Bromberg Z, Ramadhan Lasu AA, Arbel-Alon S, Edvardson S, Tarshish M, Riek LP, Lako RL, Reubinoff B, Lebendiker M, Yaish D, Stavsky A, Galun E.
J Autoimmun. 2020 Aug;112:102462. doi: 10.1016/j.jaut.2020.102462. Epub 2020 Apr 10.
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Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players.
Veksler R, Vazana U, Serlin Y, Prager O, Ofer J, Shemen N, Fisher AM, Minaeva O, Hua N, Saar-Ashkenazy R, Benou I, Riklin-Raviv T, Parker E, Mumby G, Kamintsky L, Beyea S, Bowen CV, Shelef I, O'Keeffe E, Campbell M, Kaufer D, Goldstein LE, Friedman A.
Brain. 2020 Jun 1;143(6):1826-1842. doi: 10.1093/brain/awaa140.
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The role of spreading depolarizations and electrographic seizures in early injury progression of the rat photothrombosis stroke model.
Schoknecht K, Kikhia M, Lemale CL, Liotta A, Lublinsky S, Mueller S, Boehm-Sturm P, Friedman A, Dreier JP.
J Cereb Blood Flow Metab. 2021 Feb;41(2):413-430. doi: 10.1177/0271678X20915801. Epub 2020 Apr 2.
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Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?
Klein P, Friedman A, Hameed MQ, Kaminski RM, Bar-Klein G, Klitgaard H, Koepp M, Jozwiak S, Prince DA, Rotenberg A, Twyman R, Vezzani A, Wong M, Löscher W.
Epilepsia. 2020 Mar;61(3):359-386. doi: 10.1111/epi.16450.
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Midazolam and isoflurane combination reduces late brain damage in the paraoxon-induced status epilepticus rat model.
Swissa E, Bar-Klein G, Serlin Y, Weissberg I, Kamintsky L, Eisenkraft A, Statlender L, Shrot S, Rosman Y, Prager O, Friedman A.
Neurotoxicology. 2020 May;78:99-105. doi: 10.1016/j.neuro.2020.02.007. Epub 2020 Feb 18.
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Structural, Molecular, and Functional Alterations of the Blood-Brain Barrier during Epileptogenesis and Epilepsy: A Cause, Consequence, or Both?
Löscher W, Friedman A.
Int J Mol Sci. 2020 Jan 16;21(2):591. doi: 10.3390/ijms21020591.
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Paroxysmal slow cortical activity in Alzheimer's disease and epilepsy is associated with blood-brain barrier dysfunction.
Milikovsky DZ, Ofer J, Senatorov VV Jr, Friedman AR, Prager O, Sheintuch L, Elazari N, Veksler R, Zelig D, Weissberg I, Bar-Klein G, Swissa E, Hanael E, Ben-Arie G, Schefenbauer O, Kamintsky L, Saar-Ashkenazy R, Shelef I, Shamir MH, Goldberg I, Glik A, Benninger F, Kaufer D, Friedman A.
Sci Transl Med. 2019 Dec 4;11(521):eaaw8954. doi: 10.1126/scitranslmed.aaw8954.
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Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction.
Senatorov VV Jr, Friedman AR, Milikovsky DZ, Ofer J, Saar-Ashkenazy R, Charbash A, Jahan N, Chin G, Mihaly E, Lin JM, Ramsay HJ, Moghbel A, Preininger MK, Eddings CR, Harrison HV, Patel R, Shen Y, Ghanim H, Sheng H, Veksler R, Sudmant PH, Becker A, Hart B, Rogawski MA, Dillin A, Friedman A, Kaufer D.
Sci Transl Med. 2019 Dec 4;11(521):eaaw8283. doi: 10.1126/scitranslmed.aaw8283.
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Blood-brain barrier imaging as a potential biomarker for bipolar disorder progression.
Kamintsky L, Cairns KA, Veksler R, Bowen C, Beyea SD, Friedman A, Calkin C.
Neuroimage Clin. 2020;26:102049. doi: 10.1016/j.nicl.2019.102049. Epub 2019 Oct 22.
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Blood-brain barrier dysfunction in status epileptics: Mechanisms and role in epileptogenesis.
Swissa E, Serlin Y, Vazana U, Prager O, Friedman A.
Epilepsy Behav. 2019 Dec;101(Pt B):106285. doi: 10.1016/j.yebeh.2019.04.038. Epub 2019 Nov 8.
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Dynamic Blood-Brain Barrier Regulation in Mild Traumatic Brain Injury.
O'Keeffe E, Kelly E, Liu Y, Giordano C, Wallace E, Hynes M, Tiernan S, Meagher A, Greene C, Hughes S, Burke T, Kealy J, Doyle N, Hay A, Farrell M, Grant GA, Friedman A, Veksler R, Molloy MG, Meaney JF, Pender N, Camarillo D, Doherty CP, Campbell M.
J Neurotrauma. 2020 Jan 15;37(2):347-356. doi: 10.1089/neu.2019.6483. Epub 2019 Nov 8.
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Early blood-brain barrier dysfunction predicts neurological outcome following aneurysmal subarachnoid hemorrhage.
Lublinsky S, Major S, Kola V, Horst V, Santos E, Platz J, Sakowitz O, Scheel M, Dohmen C, Graf R, Vatter H, Wolf S, Vajkoczy P, Shelef I, Woitzik J, Martus P, Dreier JP, Friedman A.
EBioMedicine. 2019 May;43:460-472. doi: 10.1016/j.ebiom.2019.04.054.
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Combining white matter diffusion and geometry for tract-specific alignment and variability analysis.
Benou I, Veksler R, Friedman A, Raviv TR.
Neuroimage. 2019 Oct 15;200:674-689. doi: 10.1016/j.neuroimage.2019.05.003. Epub 2019 May 13.
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Blood-brain barrier dysfunction in canine epileptic seizures detected by dynamic contrast-enhanced magnetic resonance imaging.
Hanael E, Veksler R, Friedman A, Bar-Klein G, Senatorov VV Jr, Kaufer D, Konstantin L, Elkin M, Chai O, Peery D, Shamir MH.
Epilepsia. 2019 May;60(5):1005-1016. doi: 10.1111/epi.14739.
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Blood-Brain Barrier Leakage: A New Biomarker in Transient Ischemic Attacks.
Serlin Y, Ofer J, Ben-Arie G, Veksler R, Ifergane G, Shelef I, Minuk J, Horev A, Friedman A.
Stroke. 2019 May;50(5):1266-1269. doi: 10.1161/STROKEAHA.119.025247.
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Victims of War: Dehydroepiandrosterone Concentrations in Hair and Their Associations with Trauma Sequelae in Palestinian Adolescents Living in the West Bank.
Schindler L, Shaheen M, Saar-Ashkenazy R, Bani Odeh K, Sass SH, Friedman A, Kirschbaum C.
Brain Sci. 2019 Jan 23;9(2):20. doi: 10.3390/brainsci9020020.
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Seizure-induced microvascular injury is associated with impaired neurovascular coupling and blood-brain barrier dysfunction.
Prager O, Kamintsky L, Hasam-Henderson LA, Schoknecht K, Wuntke V, Papageorgiou I, Swolinsky J, Muoio V, Bar-Klein G, Vazana U, Heinemann U, Friedman A, Kovács R.
Epilepsia. 2019 Feb;60(2):322-336. doi: 10.1111/epi.14631. Epub 2019 Jan 4.
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Changes of dimension of EEG/ECoG nonlinear dynamics predict epileptogenesis and therapy outcomes.
Rizzi M, Brandt C, Weissberg I, Milikovsky DZ, Pauletti A, Terrone G, Salamone A, Frigerio F, Löscher W, Friedman A, Vezzani A.
Neurobiol Dis. 2019 Apr;124:373-378. doi: 10.1016/j.nbd.2018.12.014. Epub 2018 Dec 24.
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Bioenergetic Mechanisms of Seizure Control.
Kovács R, Gerevich Z, Friedman A, Otáhal J, Prager O, Gabriel S, Berndt N.
Front Cell Neurosci. 2018 Oct 8;12:335. doi: 10.3389/fncel.2018.00335. eCollection 2018.
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Evidence for peri-ictal blood-brain barrier dysfunction in patients with epilepsy.
Rüber T, David B, Lüchters G, Nass RD, Friedman A, Surges R, Stöcker T, Weber B, Deichmann R, Schlaug G, Hattingen E, Elger CE.
Brain. 2018 Oct 1;141(10):2952-2965. doi: 10.1093/brain/awy242.
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Victims of war-Psychoendocrine evidence for the impact of traumatic stress on psychological well-being of adolescents growing up during the Israeli-Palestinian conflict.
Shaheen M, Schindler L, Saar-Ashkenazy R, Bani Odeh K, Soreq H, Friedman A, Kirschbaum C.
Psychophysiology. 2020 Jan;57(1):e13271. doi: 10.1111/psyp.13271. Epub 2018 Aug 13.
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Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.
Tagge CA, Fisher AM, Minaeva OV, Gaudreau-Balderrama A, Moncaster JA, Zhang XL, Wojnarowicz MW, Casey N, Lu H, Kokiko-Cochran ON, Saman S, Ericsson M, Onos KD, Veksler R, Senatorov VV Jr, Kondo A, Zhou XZ, Miry O, Vose LR, Gopaul KR, Upreti C, Nowinski CJ, Cantu RC, Alvarez VE, Hildebrandt AM, Franz ES, Konrad J, Hamilton JA, Hua N, Tripodis Y, Anderson AT, Howell GR, Kaufer D, Hall GF, Lu KP, Ransohoff RM, Cleveland RO, Kowall NW, Stein TD, Lamb BT, Huber BR, Moss WC, Friedman A, Stanton PK, McKee AC, Goldstein LE.
Brain. 2018 Feb 1;141(2):422-458. doi: 10.1093/brain/awx350.
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Epilepsy as a Network Disorder (1): What can we learn from other network disorders such as autistic spectrum disorder and mood disorders?
Kanner AM, Scharfman H, Jette N, Anagnostou E, Bernard C, Camfield C, Camfield P, Legg K, Dinstein I, Giacobbe P, Friedman A, Pohlmann-Eden B.
Epilepsy Behav. 2017 Dec;77:106-113. doi: 10.1016/j.yebeh.2017.09.014. Epub 2017 Oct 26.
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Epilepsy as a Network Disorder (2): What can we learn from other network disorders such as dementia and schizophrenia, and what are the implications for translational research?
Scharfman HE, Kanner AM, Friedman A, Blümcke I, Crocker CE, Cendes F, Diaz-Arrastia R, Förstl H, Fenton AA, Grace AA, Palop J, Morrison J, Nehlig A, Prasad A, Wilcox KS, Jette N, Pohlmann-Eden B.
Epilepsy Behav. 2018 Jan;78:302-312. doi: 10.1016/j.yebeh.2017.09.016. Epub 2017 Oct 31.
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Quantifying response to intracranial pressure normalization in idiopathic intracranial hypertension via dynamic neuroimaging.
Lublinsky S, Kesler A, Friedman A, Horev A, Shelef I.
J Magn Reson Imaging. 2018 Apr;47(4):913-927. doi: 10.1002/jmri.25857. Epub 2017 Sep 27.
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Simulation of spreading depolarization trajectories in cerebral cortex: Correlation of velocity and susceptibility in patients with aneurysmal subarachnoid hemorrhage.
Milakara D, Grozea C, Dahlem M, Major S, Winkler MKL, Lückl J, Scheel M, Kola V, Schoknecht K, Lublinsky S, Friedman A, Martus P, Hartings JA, Woitzik J, Dreier JP.
Neuroimage Clin. 2017 Sep 6;16:524-538. doi: 10.1016/j.nicl.2017.09.005. eCollection 2017.
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Spreading depolarization is not an epiphenomenon but the principal mechanism of the cytotoxic edema in various gray matter structures of the brain during stroke.
Dreier JP, Lemale CL, Kola V, Friedman A, Schoknecht K.
Neuropharmacology. 2018 May 15;134(Pt B):189-207. doi: 10.1016/j.neuropharm.2017.09.027. Epub 2017 Sep 21.
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Event-Associated Oxygen Consumption Rate Increases ca. Five-Fold When Interictal Activity Transforms into Seizure-Like Events In Vitro.
Schoknecht K, Berndt N, Rösner J, Heinemann U, Dreier JP, Kovács R, Friedman A, Liotta A.
Int J Mol Sci. 2017 Sep 7;18(9):1925. doi: 10.3390/ijms18091925.
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TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults.
Kim SY, Senatorov VV Jr, Morrissey CS, Lippmann K, Vazquez O, Milikovsky DZ, Gu F, Parada I, Prince DA, Becker AJ, Heinemann U, Friedman A, Kaufer D.
Sci Rep. 2017 Aug 9;7(1):7711. doi: 10.1038/s41598-017-07394-3.
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Neuroinflammation imaging markers for epileptogenesis.
Koepp MJ, Årstad E, Bankstahl JP, Dedeurwaerdere S, Friedman A, Potschka H, Ravizza T, Theodore WH, Baram TZ.
Epilepsia. 2017 Jul;58 Suppl 3:11-19. doi: 10.1111/epi.13778.
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Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity.
Bekenstein U, Mishra N, Milikovsky DZ, Hanin G, Zelig D, Sheintuch L, Berson A, Greenberg DS, Friedman A, Soreq H.
Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4996-E5005. doi: 10.1073/pnas.1701201114. Epub 2017 Jun 5.
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Role of neural barriers in the pathogenesis and outcome of
Streptococcus pneumoniae meningitis.
Prager O, Friedman A, Nebenzahl YM.
Exp Ther Med. 2017 Mar;13(3):799-809. doi: 10.3892/etm.2017.4082. Epub 2017 Jan 24.
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Imaging blood-brain barrier dysfunction as a biomarker for epileptogenesis.
Bar-Klein G, Lublinsky S, Kamintsky L, Noyman I, Veksler R, Dalipaj H, Senatorov VV Jr, Swissa E, Rosenbach D, Elazary N, Milikovsky DZ, Milk N, Kassirer M, Rosman Y, Serlin Y, Eisenkraft A, Chassidim Y, Parmet Y, Kaufer D, Friedman A.
Brain. 2017 Jun 1;140(6):1692-1705. doi: 10.1093/brain/awx073.
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Electrocorticographic Dynamics as a Novel Biomarker in Five Models of Epileptogenesis.
Milikovsky DZ, Weissberg I, Kamintsky L, Lippmann K, Schefenbauer O, Frigerio F, Rizzi M, Sheintuch L, Zelig D, Ofer J, Vezzani A, Friedman A.
J Neurosci. 2017 Apr 26;37(17):4450-4461. doi: 10.1523/JNEUROSCI.2446-16.2017. Epub 2017 Mar 22.
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WONOEP appraisal: Biomarkers of epilepsy-associated comorbidities.
Ravizza T, Onat FY, Brooks-Kayal AR, Depaulis A, Galanopoulou AS, Mazarati A, Numis AL, Sankar R, Friedman A.
Epilepsia. 2017 Mar;58(3):331-342. doi: 10.1111/epi.13652. Epub 2016 Dec 30.
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WONOEP appraisal: Imaging biomarkers in epilepsy.
van Vliet EA, Dedeurwaerdere S, Cole AJ, Friedman A, Koepp MJ, Potschka H, Immonen R, Pitkänen A, Federico P.
Epilepsia. 2017 Mar;58(3):315-330. doi: 10.1111/epi.13621. Epub 2016 Nov 24.
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Isoflurane prevents acquired epilepsy in rat models of temporal lobe epilepsy.
Bar-Klein G, Klee R, Brandt C, Bankstahl M, Bascuñana P, Töllner K, Dalipaj H, Bankstahl JP, Friedman A, Löscher W.
Ann Neurol. 2016 Dec;80(6):896-908. doi: 10.1002/ana.24804.
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Corrigendum: Following a potential epileptogenic insult, prolonged high rates of nonlinear dynamical regimes of intermittency type is the hallmark of epileptogenesis.
Rizzi M, Weissberg I, Milikovsky DZ, Friedman A.
Sci Rep. 2016 Oct 14;6:35510. doi: 10.1038/srep35510.
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Following a potential epileptogenic insult, prolonged high rates of nonlinear dynamical regimes of intermittency type is the hallmark of epileptogenesis.
Rizzi M, Weissberg I, Milikovsky DZ, Friedman A.
Sci Rep. 2016 Aug 4;6:31129. doi: 10.1038/srep31129.
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Glutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery.
Vazana U, Veksler R, Pell GS, Prager O, Fassler M, Chassidim Y, Roth Y, Shahar H, Zangen A, Raccah R, Onesti E, Ceccanti M, Colonnese C, Santoro A, Salvati M, D'Elia A, Nucciarelli V, Inghilleri M, Friedman A.
J Neurosci. 2016 Jul 20;36(29):7727-39. doi: 10.1523/JNEUROSCI.0587-16.2016.
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Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group.
Dreier JP, Fabricius M, Ayata C, Sakowitz OW, Shuttleworth CW, Dohmen C, Graf R, Vajkoczy P, Helbok R, Suzuki M, Schiefecker AJ, Major S, Winkler MK, Kang EJ, Milakara D, Oliveira-Ferreira AI, Reiffurth C, Revankar GS, Sugimoto K, Dengler NF, Hecht N, Foreman B, Feyen B, Kondziella D, Friberg CK, Piilgaard H, Rosenthal ES, Westover MB, Maslarova A, Santos E, Hertle D, Sánchez-Porras R, Jewell SL, Balança B, Platz J, Hinzman JM, Lückl J, Schoknecht K, Schöll M, Drenckhahn C, Feuerstein D, Eriksen N, Horst V, Bretz JS, Jahnke P, Scheel M, Bohner G, Rostrup E, Pakkenberg B, Heinemann U, Claassen J, Carlson AP, Kowoll CM, Lublinsky S, Chassidim Y, Shelef I, Friedman A, Brinker G, Reiner M, Kirov SA, Andrew RD, Farkas E, Güresir E, Vatter H, Chung LS, Brennan KC, Lieutaud T, Marinesco S, Maas AI, Sahuquillo J, Dahlem MA, Richter F, Herreras O, Boutelle MG, Okonkwo DO, Bullock MR, Witte OW, Martus P, van den Maagdenberg AM, Ferrari MD, Dijkhuizen RM, Shutter LA, Andaluz N, Schulte AP, MacVicar B, Watanabe T, Woitzik J, Lauritzen M, Strong AJ, Hartings JA.
J Cereb Blood Flow Metab. 2017 May;37(5):1595-1625. doi: 10.1177/0271678X16654496. Epub 2016 Jan 1.
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Advances in the development of biomarkers for epilepsy.
Pitkänen A, Löscher W, Vezzani A, Becker AJ, Simonato M, Lukasiuk K, Gröhn O, Bankstahl JP, Friedman A, Aronica E, Gorter JA, Ravizza T, Sisodiya SM, Kokaia M, Beck H.
Lancet Neurol. 2016 Jul;15(8):843-856. doi: 10.1016/S1474-4422(16)00112-5.
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A potential role for glia-derived extracellular matrix remodeling in postinjury epilepsy.
Kim SY, Porter BE, Friedman A, Kaufer D.
J Neurosci Res. 2016 Sep;94(9):794-803. doi: 10.1002/jnr.23758. Epub 2016 Jun 5.
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Epileptiform activity and spreading depolarization in the blood-brain barrier-disrupted peri-infarct hippocampus are associated with impaired GABAergic inhibition and synaptic plasticity.
Lippmann K, Kamintsky L, Kim SY, Lublinsky S, Prager O, Nichtweiss JF, Salar S, Kaufer D, Heinemann U, Friedman A.
J Cereb Blood Flow Metab. 2017 May;37(5):1803-1819. doi: 10.1177/0271678X16652631. Epub 2016 Jan 1.
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Acute Stress and Perceptual Load Consume the Same Attentional Resources: A Behavioral-ERP Study.
Tiferet-Dweck C, Hensel M, Kirschbaum C, Tzelgov J, Friedman A, Salti M.
PLoS One. 2016 May 19;11(5):e0154622. doi: 10.1371/journal.pone.0154622. eCollection 2016.
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Synaptic plasticity in area CA1 of rat hippocampal slices following intraventricular application of albumin.
Salar S, Lapilover E, Müller J, Hollnagel JO, Lippmann K, Friedman A, Heinemann U.
Neurobiol Dis. 2016 Jul;91:155-65. doi: 10.1016/j.nbd.2016.03.008. Epub 2016 Mar 10.
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Angiographic evidence of proliferative retinopathy predicts neuropsychiatric morbidity in diabetic patients.
Serlin Y, Shafat T, Levy J, Winter A, Shneck M, Knyazer B, Parmet Y, Shalev H, Ur E, Friedman A.
Psychoneuroendocrinology. 2016 May;67:163-70. doi: 10.1016/j.psyneuen.2016.02.009. Epub 2016 Feb 12.
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Breakdown of Inter-Hemispheric Connectivity Is Associated with Posttraumatic Symptomatology and Memory Impairment.
Saar-Ashkenazy R, Veksler R, Guez J, Jacob Y, Shelef I, Shalev H, Friedman A, Cohen JE.
PLoS One. 2016 Feb 10;11(2):e0144766. doi: 10.1371/journal.pone.0144766. eCollection 2016.
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Corrigendum: Acute stress facilitates long-lasting changes in cholinergic gene expression.
Kaufer D, Friedman A, Seidman S, Soreq H.
Nature. 2016 Mar 3;531(7592):126. doi: 10.1038/nature16180. Epub 2015 Nov 25.
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Autosomal dominant epilepsy with auditory features: a new LGI1 family including a phenocopy with cortical dysplasia.
Klein KM, Pendziwiat M, Cohen R, Appenzeller S, de Kovel CG, Rosenow F, Koeleman BP, Kuhlenbäumer G, Sheintuch L, Veksler R, Friedman A, Afawi Z, Helbig I.
J Neurol. 2016 Jan;263(1):11-6. doi: 10.1007/s00415-015-7921-2. Epub 2015 Oct 12.
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Altered processing of visual emotional stimuli in posttraumatic stress disorder: an event-related potential study.
Saar-Ashkenazy R, Shalev H, Kanthak MK, Guez J, Friedman A, Cohen JE.
Psychiatry Res. 2015 Aug 30;233(2):165-74. doi: 10.1016/j.pscychresns.2015.05.015. Epub 2015 Jun 19.
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Differential TGF-β Signaling in Glial Subsets Underlies IL-6-Mediated Epileptogenesis in Mice.
Levy N, Milikovsky DZ, Baranauskas G, Vinogradov E, David Y, Ketzef M, Abutbul S, Weissberg I, Kamintsky L, Fleidervish I, Friedman A, Monsonego A.
J Immunol. 2015 Aug 15;195(4):1713-22. doi: 10.4049/jimmunol.1401446. Epub 2015 Jul 1.
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In response: Multifactorial basis of epilepsy in patients with neurocysticercosis.
Nash TE, Mahanty S, Loeb JA, Theodore WH, Friedman A, Sander JW, Singh G, Cavalheiro E, Del Brutto OH, Takayanagui OM, Fleury A, Verastegui M, Preux PM, Montano S, Pretell EJ, White AC Jr, Gonzales AE, Gilman RH, Garcia HH.
Epilepsia. 2015 Jun;56(6):975-6. doi: 10.1111/epi.12986.
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Blood-brain barrier in health and disease.
Friedman A, Kaufer D.
Semin Cell Dev Biol. 2015 Feb;38:1. doi: 10.1016/j.semcdb.2015.03.006.
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Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood-brain barrier dysfunction.
Weissberg I, Wood L, Kamintsky L, Vazquez O, Milikovsky DZ, Alexander A, Oppenheim H, Ardizzone C, Becker A, Frigerio F, Vezzani A, Buckwalter MS, Huguenard JR, Friedman A, Kaufer D.
Neurobiol Dis. 2015 Jun;78:115-25. doi: 10.1016/j.nbd.2015.02.029. Epub 2015 Mar 30.
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Anatomy and physiology of the blood-brain barrier.
Serlin Y, Shelef I, Knyazer B, Friedman A.
Semin Cell Dev Biol. 2015 Feb;38:2-6. doi: 10.1016/j.semcdb.2015.01.002. Epub 2015 Feb 11.
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Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures.
Gilad D, Shorer S, Ketzef M, Friedman A, Sekler I, Aizenman E, Hershfinkel M.
Neurobiol Dis. 2015 Sep;81:4-13. doi: 10.1016/j.nbd.2014.12.020. Epub 2015 Jan 3.
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Neurocysticercosis: A natural human model of epileptogenesis.
Nash TE, Mahanty S, Loeb JA, Theodore WH, Friedman A, Sander JW, Singh G, Cavalheiro E, Del Brutto OH, Takayanagui OM, Fleury A, Verastegui M, Preux PM, Montano S, Pretell EJ, White AC Jr, Gonzales AE, Gilman RH, Garcia HH.
Epilepsia. 2015 Feb;56(2):177-83. doi: 10.1111/epi.12849. Epub 2014 Dec 23.
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The role of cytosolic phospholipase A2 α in amyloid precursor protein induction by amyloid beta1-42 : implication for neurodegeneration.
Sagy-Bross C, Kasianov K, Solomonov Y, Braiman A, Friedman A, Hadad N, Levy R.
J Neurochem. 2015 Mar;132(5):559-71. doi: 10.1111/jnc.13012. Epub 2015 Feb 3.
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Blood-brain barrier imaging in human neuropathologies.
Veksler R, Shelef I, Friedman A.
Arch Med Res. 2014 Nov;45(8):646-52. doi: 10.1016/j.arcmed.2014.11.016. Epub 2014 Nov 29.
.
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Imaging blood-brain barrier dysfunction in football players.
Weissberg I, Veksler R, Kamintsky L, Saar-Ashkenazy R, Milikovsky DZ, Shelef I, Friedman A.
JAMA Neurol. 2014 Nov;71(11):1453-5. doi: 10.1001/jamaneurol.2014.2682.
PMID: 25383774 No abstract available.
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sec-Butyl-propylacetamide (SPD) and two of its stereoisomers rapidly terminate paraoxon-induced status epilepticus in rats.
Bar-Klein G, Swissa E, Kamintsky L, Shekh-Ahmad T, Saar-Ashkenazy R, Hubary Y, Shrot S, Stetlander L, Eisenkraft A, Friedman A, Bialer M.
Epilepsia. 2014 Dec;55(12):1953-8. doi: 10.1111/epi.12838. Epub 2014 Nov 6.
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How spreading depolarization can be the pathophysiological correlate of both migraine aura and stroke.
Dreier JP, Reiffurth C, Woitzik J, Hartings JA, Drenckhahn C, Windler C, Friedman A, MacVicar B, Herreras O; COSBID study group.
Acta Neurochir Suppl. 2015;120:137-40. doi: 10.1007/978-3-319-04981-6_23.
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Should losartan be administered following brain injury?
Friedman A, Bar-Klein G, Serlin Y, Parmet Y, Heinemann U, Kaufer D.
Expert Rev Neurother. 2014 Dec;14(12):1365-75. doi: 10.1586/14737175.2014.972945. Epub 2014 Oct 27.
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Monitoring stroke progression: in vivo imaging of cortical perfusion, blood-brain barrier permeability and cellular damage in the rat photothrombosis model.
Schoknecht K, Prager O, Vazana U, Kamintsky L, Harhausen D, Zille M, Figge L, Chassidim Y, Schellenberger E, Kovács R, Heinemann U, Friedman A.
J Cereb Blood Flow Metab. 2014 Nov;34(11):1791-801. doi: 10.1038/jcbfm.2014.147. Epub 2014 Aug 27.
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Blood-brain barrier dysfunction can contribute to pharmacoresistance of seizures.
Salar S, Maslarova A, Lippmann K, Nichtweiss J, Weissberg I, Sheintuch L, Kunz WS, Shorer Z, Friedman A, Heinemann U.
Epilepsia. 2014 Aug;55(8):1255-63. doi: 10.1111/epi.12713. Epub 2014 Jul 3.
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Prevention of organophosphate-induced chronic epilepsy by early benzodiazepine treatment.
Shrot S, Ramaty E, Biala Y, Bar-Klein G, Daninos M, Kamintsky L, Makarovsky I, Statlender L, Rosman Y, Krivoy A, Lavon O, Kassirer M, Friedman A, Yaari Y.
Toxicology. 2014 Sep 2;323:19-25. doi: 10.1016/j.tox.2014.05.010. Epub 2014 Jun 2.
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Losartan prevents acquired epilepsy via TGF-β signaling suppression.
Bar-Klein G, Cacheaux LP, Kamintsky L, Prager O, Weissberg I, Schoknecht K, Cheng P, Kim SY, Wood L, Heinemann U, Kaufer D, Friedman A.
Ann Neurol. 2014 Jun;75(6):864-75. doi: 10.1002/ana.24147. Epub 2014 May 28.
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Reduced corpus-callosum volume in posttraumatic stress disorder highlights the importance of interhemispheric connectivity for associative memory.
Saar-Ashkenazy R, Cohen JE, Guez J, Gasho C, Shelef I, Friedman A, Shalev H.
J Trauma Stress. 2014 Feb;27(1):18-26. doi: 10.1002/jts.21887. Epub 2014 Jan 28.
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Preferential lentiviral targeting of astrocytes in the central nervous system.
Fassler M, Weissberg I, Levy N, Diaz-Griffero F, Monsonego A, Friedman A, Taube R.
PLoS One. 2013 Oct 2;8(10):e76092. doi: 10.1371/journal.pone.0076092. eCollection 2013.
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Acetylcholinesterase activity in the cerebrospinal fluid of dogs with seizures.
Chai O, Sommer A, Zimmerman G, Soreq H, Friedman A, Bdolah-Abram T, Aroch I, Shamir MH.
Vet J. 2013 Oct;198(1):292-4. doi: 10.1016/j.tvjl.2013.06.027. Epub 2013 Aug 27.
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Novel fluorescein angiography-based computer-aided algorithm for assessment of retinal vessel permeability.
Serlin Y, Tal G, Chassidim Y, Parmet Y, Tomkins O, Knyazer B, Friedman A, Levy J.
PLoS One. 2013 Apr 23;8(4):e61599. doi: 10.1371/journal.pone.0061599. Print 2013.
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Increased susceptibility to acetylcholine in the entorhinal cortex of pilocarpine-treated rats involves alterations in KCNQ channels.
Maslarova A, Salar S, Lapilover E, Friedman A, Veh RW, Heinemann U.
Neurobiol Dis. 2013 Aug;56:14-24. doi: 10.1016/j.nbd.2013.02.016. Epub 2013 Apr 11.
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Quantitative imaging assessment of blood-brain barrier permeability in humans.
Chassidim Y, Veksler R, Lublinsky S, Pell GS, Friedman A, Shelef I.
Fluids Barriers CNS. 2013 Feb 7;10(1):9. doi: 10.1186/2045-8118-10-9.
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Impaired neurovascular coupling to ictal epileptic activity and spreading depolarization in a patient with subarachnoid hemorrhage: possible link to blood-brain barrier dysfunction.
Winkler MK, Chassidim Y, Lublinsky S, Revankar GS, Major S, Kang EJ, Oliveira-Ferreira AI, Woitzik J, Sandow N, Scheel M, Friedman A, Dreier JP.
Epilepsia. 2012 Nov;53 Suppl 6(0 6):22-30. doi: 10.1111/j.1528-1167.2012.03699.x.
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Albumin storage in neoplastic astroglial elements of gangliogliomas.
Schmitz AK, Grote A, Raabe A, Urbach H, Friedman A, von Lehe M, Becker AJ, Niehusmann P.
Seizure. 2013 Mar;22(2):144-50. doi: 10.1016/j.seizure.2012.10.014. Epub 2012 Nov 20.
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Detection of cerebral hyperperfusion syndrome after carotid endarterectomy with CT perfusion.
Schoknecht K, Gabi S, Ifergane G, Friedman A, Shelef I.
J Neuroimaging. 2014 May-Jun;24(3):295-7. doi: 10.1111/j.1552-6569.2012.00773.x. Epub 2012 Nov 19.
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Overview and introduction: the blood-brain barrier in health and disease.
Abbott NJ, Friedman A.
Epilepsia. 2012 Nov;53 Suppl 6(0 6):1-6. doi: 10.1111/j.1528-1167.2012.03696.x.
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Long-lasting pro-ictogenic effects induced in vivo by rat brain exposure to serum albumin in the absence of concomitant pathology.
Frigerio F, Frasca A, Weissberg I, Parrella S, Friedman A, Vezzani A, Noé FM.
Epilepsia. 2012 Nov;53(11):1887-97. doi: 10.1111/j.1528-1167.2012.03666.x. Epub 2012 Sep 17.
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Albumin is taken up by hippocampal NG2 cells and astrocytes and decreases gap junction coupling.
Braganza O, Bedner P, Hüttmann K, von Staden E, Friedman A, Seifert G, Steinhäuser C.
Epilepsia. 2012 Nov;53(11):1898-906. doi: 10.1111/j.1528-1167.2012.03665.x. Epub 2012 Sep 11.
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Stress-induced altered cholinergic-glutamatergic interactions in the mouse hippocampus.
Pavlovsky L, Bitan Y, Shalev H, Serlin Y, Friedman A.
Brain Res. 2012 Sep 7;1472:99-106. doi: 10.1016/j.brainres.2012.05.057. Epub 2012 Jul 14.
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Stimulation of the sphenopalatine ganglion induces reperfusion and blood-brain barrier protection in the photothrombotic stroke model.
Levi H, Schoknecht K, Prager O, Chassidim Y, Weissberg I, Serlin Y, Friedman A.
PLoS One. 2012;7(6):e39636. doi: 10.1371/journal.pone.0039636. Epub 2012 Jun 22.
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Fluoxetine induces vasodilatation of cerebral arterioles by co-modulating NO/muscarinic signalling.
Ofek K, Schoknecht K, Melamed-Book N, Heinemann U, Friedman A, Soreq H.
J Cell Mol Med. 2012 Nov;16(11):2736-44. doi: 10.1111/j.1582-4934.2012.01596.x.
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Finding a better drug for epilepsy: antiinflammatory targets.
Dedeurwaerdere S, Friedman A, Fabene PF, Mazarati A, Murashima YL, Vezzani A, Baram TZ.
Epilepsia. 2012 Jul;53(7):1113-8. doi: 10.1111/j.1528-1167.2012.03520.x. Epub 2012 Jun 12.
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Acetylcholinesterase loosens the brain's cholinergic anti-inflammatory response and promotes epileptogenesis.
Gnatek Y, Zimmerman G, Goll Y, Najami N, Soreq H, Friedman A.
Front Mol Neurosci. 2012 May 18;5:66. doi: 10.3389/fnmol.2012.00066. eCollection 2012.
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Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice.
Berson A, Barbash S, Shaltiel G, Goll Y, Hanin G, Greenberg DS, Ketzef M, Becker AJ, Friedman A, Soreq H.
EMBO Mol Med. 2012 Aug;4(8):730-42. doi: 10.1002/emmm.201100995. Epub 2012 May 25.
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The role of inflammation in epileptogenesis.
Vezzani A, Friedman A, Dingledine RJ.
Neuropharmacology. 2013 Jun;69:16-24. doi: 10.1016/j.neuropharm.2012.04.004. Epub 2012 Apr 13.
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Pathophysiology of the neurovascular unit: disease cause or consequence?
Stanimirovic DB, Friedman A.
J Cereb Blood Flow Metab. 2012 Jul;32(7):1207-21. doi: 10.1038/jcbfm.2012.25. Epub 2012 Mar 7.
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Blood-brain barrier dysfunction, TGFβ signaling, and astrocyte dysfunction in epilepsy.
Heinemann U, Kaufer D, Friedman A.
Glia. 2012 Aug;60(8):1251-7. doi: 10.1002/glia.22311. Epub 2012 Feb 29.
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Cliniconeuropathologic correlations show astroglial albumin storage as a common factor in epileptogenic vascular lesions.
Raabe A, Schmitz AK, Pernhorst K, Grote A, von der Brelie C, Urbach H, Friedman A, Becker AJ, Elger CE, Niehusmann P.
Epilepsia. 2012 Mar;53(3):539-48. doi: 10.1111/j.1528-1167.2012.03405.x.
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Emotional brain rhythms and their impairment in post-traumatic patients.
Cohen JE, Shalev H, Admon R, Hefetz S, Gasho CJ, Shachar LJ, Shelef I, Hendler T, Friedman A.
Hum Brain Mapp. 2013 Jun;34(6):1344-56. doi: 10.1002/hbm.21516. Epub 2012 Feb 14.
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Role of Blood-Brain Barrier Dysfunction in Epileptogenesis.
Friedman A, Heinemann U.
In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.
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Brain inflammation as a biomarker in epilepsy.
Vezzani A, Friedman A.
Biomark Med. 2011 Oct;5(5):607-14. doi: 10.2217/bmm.11.61.
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Blood-brain barrier dysfunction, status epilepticus, seizures, and epilepsy: a puzzle of a chicken and egg?
Friedman A.
Epilepsia. 2011 Oct;52 Suppl 8(Suppl 8):19-20. doi: 10.1111/j.1528-1167.2011.03227.x.
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Blood-brain barrier breakdown and blood-brain communication in neurological and psychiatric diseases.
Friedman A, Kaufer D.
Cardiovasc Psychiatry Neurol. 2011;2011:431470. doi: 10.1155/2011/431470. Epub 2011 Jul 6.
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Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels.
Ben-David O, Pewzner-Jung Y, Brenner O, Laviad EL, Kogot-Levin A, Weissberg I, Biton IE, Pienik R, Wang E, Kelly S, Alroy J, Raas-Rothschild A, Friedman A, Brügger B, Merrill AH Jr, Futerman AH.
J Biol Chem. 2011 Aug 26;286(34):30022-33. doi: 10.1074/jbc.M111.261206. Epub 2011 Jun 24.
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Molecular cascades that mediate the influence of inflammation on epilepsy.
Friedman A, Dingledine R.
Epilepsia. 2011 May;52 Suppl 3(0 3):33-9. doi: 10.1111/j.1528-1167.2011.03034.x.
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Blood-brain barrier breakdown following traumatic brain injury: a possible role in posttraumatic epilepsy.
Tomkins O, Feintuch A, Benifla M, Cohen A, Friedman A, Shelef I.
Cardiovasc Psychiatry Neurol. 2011;2011:765923. doi: 10.1155/2011/765923. Epub 2011 Feb 22.
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Blood-brain barrier dysfunction in epileptogenesis of the temporal lobe.
Weissberg I, Reichert A, Heinemann U, Friedman A.
Epilepsy Res Treat. 2011;2011:143908. doi: 10.1155/2011/143908. Epub 2011 Jun 7.
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Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury.
Shlosberg D, Benifla M, Kaufer D, Friedman A.
Nat Rev Neurol. 2010 Jul;6(7):393-403. doi: 10.1038/nrneurol.2010.74. Epub 2010 Jun 15.
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Blood-brain barrier breakdown as a novel mechanism underlying cerebral hyperperfusion syndrome.
Ivens S, Gabriel S, Greenberg G, Friedman A, Shelef I.
J Neurol. 2010 Apr;257(4):615-20. doi: 10.1007/s00415-009-5384-z. Epub 2009 Nov 22.
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Breaching the blood-brain barrier as a gate to psychiatric disorder.
Shalev H, Serlin Y, Friedman A.
Cardiovasc Psychiatry Neurol. 2009;2009:278531. doi: 10.1155/2009/278531. Epub 2009 Aug 27.
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Erythropoietin attenuates hyperoxia-induced oxidative stress in the developing rat brain.
Sifringer M, Brait D, Weichelt U, Zimmerman G, Endesfelder S, Brehmer F, von Haefen C, Friedman A, Soreq H, Bendix I, Gerstner B, Felderhoff-Mueser U.
Brain Behav Immun. 2010 Jul;24(5):792-9. doi: 10.1016/j.bbi.2009.08.010. Epub 2009 Sep 1.
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Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis?
David Y, Cacheaux LP, Ivens S, Lapilover E, Heinemann U, Kaufer D, Friedman A.
J Neurosci. 2009 Aug 26;29(34):10588-99. doi: 10.1523/JNEUROSCI.2323-09.2009.
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Dynamic in vivo imaging of cerebral blood flow and blood-brain barrier permeability.
Prager O, Chassidim Y, Klein C, Levi H, Shelef I, Friedman A.
Neuroimage. 2010 Jan 1;49(1):337-44. doi: 10.1016/j.neuroimage.2009.08.009. Epub 2009 Aug 12.
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Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis.
Cacheaux LP, Ivens S, David Y, Lakhter AJ, Bar-Klein G, Shapira M, Heinemann U, Friedman A, Kaufer D.
J Neurosci. 2009 Jul 15;29(28):8927-35. doi: 10.1523/JNEUROSCI.0430-09.2009.
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Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy.
Friedman A, Kaufer D, Heinemann U.
Epilepsy Res. 2009 Aug;85(2-3):142-9. doi: 10.1016/j.eplepsyres.2009.03.005. Epub 2009 Apr 11.
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Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats.
Zimmerman G, Njunting M, Ivens S, Tolner EA, Behrens CJ, Gross M, Soreq H, Heinemann U, Friedman A.
Eur J Neurosci. 2008 Feb;27(4):965-75. doi: 10.1111/j.1460-9568.2008.06070.x.
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Cholinergic dysfunction in temporal lobe epilepsy.
Friedman A, Behrens CJ, Heinemann U.
Epilepsia. 2007;48 Suppl 5:126-30. doi: 10.1111/j.1528-1167.2007.01300.x.
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Pathogenesis of stress-associated skin disorders: exploring the brain-skin axis.
Pavlovsky L, Friedman A.
Curr Probl Dermatol. 2007;35:136-145. doi: 10.1159/000106420.
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TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis.
Ivens S, Kaufer D, Flores LP, Bechmann I, Zumsteg D, Tomkins O, Seiffert E, Heinemann U, Friedman A.
Brain. 2007 Feb;130(Pt 2):535-47. doi: 10.1093/brain/awl317. Epub 2006 Nov 21.
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Propagation of interictal discharges in temporal lobe epilepsy: correlation of spatiotemporal mapping with intracranial foramen ovale electrode recordings.
Zumsteg D, Friedman A, Wieser HG, Wennberg RA.
Clin Neurophysiol. 2006 Dec;117(12):2615-26. doi: 10.1016/j.clinph.2006.07.319. Epub 2006 Oct 6.
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Coding region paraoxonase polymorphisms dictate accentuated neuronal reactions in chronic, sub-threshold pesticide exposure.
Browne RO, Moyal-Segal LB, Zumsteg D, David Y, Kofman O, Berger A, Soreq H, Friedman A.
FASEB J. 2006 Aug;20(10):1733-5. doi: 10.1096/fj.05-5576fje. Epub 2006 Jun 28.
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Motor inhibition and learning impairments in school-aged children following exposure to organophosphate pesticides in infancy.
Kofman O, Berger A, Massarwa A, Friedman A, Jaffar AA.
Pediatr Res. 2006 Jul;60(1):88-92. doi: 10.1203/01.pdr.0000219467.47013.35.
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Source localization of interictal epileptiform discharges: comparison of three different techniques to improve signal to noise ratio.
Zumsteg D, Friedman A, Wieser HG, Wennberg RA.
Clin Neurophysiol. 2006 Mar;117(3):562-71. doi: 10.1016/j.clinph.2005.11.014. Epub 2006 Jan 19.
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Source localization of mesial temporal interictal epileptiform discharges: correlation with intracranial foramen ovale electrode recordings.
Zumsteg D, Friedman A, Wennberg RA, Wieser HG.
Clin Neurophysiol. 2005 Dec;116(12):2810-8. doi: 10.1016/j.clinph.2005.08.009. Epub 2005 Oct 25.
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Induction of sharp wave-ripple complexes in vitro and reorganization of hippocampal networks.
Behrens CJ, van den Boom LP, de Hoz L, Friedman A, Heinemann U.
Nat Neurosci. 2005 Nov;8(11):1560-7. doi: 10.1038/nn1571. Epub 2005 Oct 16.
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Focal cortical dysfunction and blood-brain barrier disruption in patients with Postconcussion syndrome.
Korn A, Golan H, Melamed I, Pascual-Marqui R, Friedman A.
J Clin Neurophysiol. 2005 Jan-Feb;22(1):1-9. doi: 10.1097/01.wnp.0000150973.24324.a7.
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Persistent BBB disruption may underlie alpha interferon-induced seizures.
Pavlovsky L, Seiffert E, Heinemann U, Korn A, Golan H, Friedman A.
J Neurol. 2005 Jan;252(1):42-6. doi: 10.1007/s00415-005-0596-3.
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Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease.
Benmoyal-Segal L, Vander T, Shifman S, Bryk B, Ebstein RP, Marcus EL, Stessman J, Darvasi A, Herishanu Y, Friedman A, Soreq H.
FASEB J. 2005 Mar;19(3):452-4. doi: 10.1096/fj.04-2106fje. Epub 2005 Jan 3.
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Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex.
Seiffert E, Dreier JP, Ivens S, Bechmann I, Tomkins O, Heinemann U, Friedman A.
J Neurosci. 2004 Sep 8;24(36):7829-36. doi: 10.1523/JNEUROSCI.1751-04.2004.
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Long-term seizure outcomes following amygdalohippocampectomy.
Wieser HG, Ortega M, Friedman A, Yonekawa Y.
J Neurosurg. 2003 Apr;98(4):751-63. doi: 10.3171/jns.2003.98.4.0751.
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Pyridostigmine enhances glutamatergic transmission in hippocampal CA1 neurons.
Pavlovsky L, Browne RO, Friedman A.
Exp Neurol. 2003 Feb;179(2):181-7. doi: 10.1016/s0014-4886(02)00016-x.
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Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity.
Meshorer E, Erb C, Gazit R, Pavlovsky L, Kaufer D, Friedman A, Glick D, Ben-Arie N, Soreq H.
Science. 2002 Jan 18;295(5554):508-12. doi: 10.1126/science.1066752.
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