In the course of our study that dysfunction of the BBB can lead to epileptogenesis and neurodegeneration, we show that the FDA approved drug Losartan blocks brain TGF-b signalling and prevent epilepsy in models of epileptogenesis. We further show that Isoflurane, a common used anaesthetic, has neuroprotective and antiepileptic effect after status epilepticus.
Losartan prevents acquired epilepsy via TGF-β signaling suppression.
Isoflurane prevents acquired epilepsy in rat models of temporal lobe epilepsy.
Please note that all fields with * are mandatory.
Getting information pack please fill in details: