The Blood-Brain Barrier (BBB) is a unique anatomical and physiological interface between the circulation system and the CNS, designed to maintain homeostasis within the extravascular-extracellular brain environment and preserve normal brain functioning. Our research is multi-disciplinary, combining basic science and human studies: we study the role of microvascular unit and BBB integrity in the normal brain and in the pathogenesis and pathophysiology of brain disorders such as epilepsy, stroke, neurodegenerative diseases, brain trauma and psychiatric diseases. We develop new approaches for detection of brain and retinal damage to allow early disease prediction and intervention, and follow-up treatment efficacy.