Patents

  • Methods of Treating Neurological Disorders. United States A pplication 15/258,862 filed on September 7 2016. Kaufer and Friedman

  • Permeability modulators of blood-brain-barrier and uses thereof. Provisional Patent Application for Friedman A . and Vazana U., August 2015.

  • Method of Treating Epilepsy with Transforming Growth Factor beta Inhibitors. Patent No. US 9,468,649 B2. October 18 2016. Kaufer D., Friedman A . and Cacheaux L. December 2009.

  • Apparatus and methods for analyzing stream of imaging data. Friedman A , Yoash Chassidim, Ofer Prager and Ilan Shelef. PCT/IL2009/000847. Patent # US 9147246 Apparatus and method for analyzing stream of imaging data; Granted: 29.09.2015.

  • A method and composition for enabling passage through the blood -brain barrier. Soreq , H., Friedman, A., Seidman, S., Kaufer, D. International patent no.: US 6,258,780 B1 WO 1998/22132

  • Synthetic antisense oligodeoxinucleotides and pharmaceutical compositions containing them. Soreq H, Seidman S, Eckstein, F, Friedman A., Kaufer D. International patent 1998 no:727611.

Chapters in Books​​​​​

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​​Yonatan Serlin, Alon Friedman and Uwe Heinemann. The Blood-Brain Barrier, In: HomeostaticControl of Brain Function. Boison D, Masino SA, eds. Oxford University Press (2015). ​​​​​​​​

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​​Dreier JP, Reiffurth C, Woitzik J, Hartings JA, Drenckhahn C, Windler C, Friedman A,  MacVicar  B,  Herreras  A.  Neurovascular  Events  After  Subarachnoid  Hemorrhage:  Towards  Experimental  and Clinical Standardization. In: Fandino J, Marbacher S, Fathi A-R, Muroi C, Keller E,  editors. Cham: Springer International Publishing; 2015. p. 137–40.​​​​

​Gutnick, M.J. and Friedman, A.1986, Synaptic and intrinsic echanisms of synchronization and epileptogenesis in the neocortex. Exp. Brain Research suppl. 14: 327-335.​​​​​​​​​​​​​

​Kaufer,  D., Friedman,  A.,  Sternfeld,  M.,  Seidman,  S.,  Beeri,  R.  Andres,  C.,  and  Soreq,  H.  1996, Central and peripheral consequences  of cholinergic imbalance in Alzheimer’s disease. In: Alzheimer Disease: From Molecular Biology to Therapy. Eds: R. Becker and E. Giacobini. Birkahauser, Boston Inc. pp. 153-158.​​​​

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​Soreq, H., Kaufer, D., Friedman, A. and Glick, D. 2000, “Blood-Brain-Barrier Modulation and Low-Level Exposure to Xenobiotics”. In: Chemical Warfare  Agents: Low Level Toxicity”. S.M. Somani and J.A. Romano, Eds., CRC Press, Boca Raton, FL pp. 121-144.​​

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​Soreq, H., Kaufer, D., Shelef, I., Golan, H., Tomkins, O., Glick, D., Reichenthal, E. and Friedman, A.  2002,  The  molecular  biology  of  Blood  Brain  Barrier  disruption  under  stress.  In:  Brain  Disease: ​​Therapeutic  strategies  and  repair.  O.  Abramsky,  A.  Miller  and  G.  Said,  Eds.,  Martin  Dunitz, Publishers, pp. 231-238.​​​​​

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​Avivi, E., Tomkins, O., Korn, A., Pavlovsky, L., Shelef, I. and Friedman, A. 2004, Persistent Blood-Brain-Barrier  Disruption  in  Humans:  A  Window  to  Neurodegenerative  Diseases,  In:  Silman,  I., Fisher, A.,  Anglister,  L​.  Michaelson,  D.  and  Soreq,  H.  (eds.) Cholinergic Mechanisms, Taylor  & Francis, London. pp. 423 – 429. ​​

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​Browne,   R.O.,   Pavlovsky,   L.,   and Friedman,   A. 2004,  Muscarinic   Neuromodulation   in   the Hippocampus  and  Parahippocampal  Region.  In:  Silman,  I., Fisher,  A.,  Anglister,  L. Michaelson, D. and Soreq, H. (eds.) Cholinergic Mechanisms, Taylor & Francis, London. pp. 499-507. ​​​​

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​​Alon  Friedman and Lev Pavlovsky, 2009. The Cholinergic Model for PTSD:  From acute stress to PTSD,  From  Neuron  to  Network  and  Behavior.  In:  STRESS:  from  molecules  to  behavior. A comprehensive analysis of the neurobiology of stress responses. Soreq, H., Friedman, A. and Kaufer. D (eds.) Chap 15. Pp. 283-296.​​​

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​Jonathan  E.  Cohen,  Gabriel  Zimmermann, Alon  Friedman  and  Hermona  Soreq.  2012. Genomic implications of anticholinesterase    sensitivities.  Anticholine

sterase    Pesticides:    Metabolism, Neurotoxicity and Epidemiology. Editors: Tetsuo Satoh and Ramesh C. Gupta. John Wiley, in press. ​​​

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​​​Alon  Friedman  and  Uwe  Heinemann.  2012.  Role  of  blood-brain  barrier  injury  in  epileptogenesis. Jasper's Basic Mechanisms of the Epilepsies. Editors: Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen and Antonio V. Delgado-Escueta, Summary published in Epilepsia, 51 (Suppl. 5): 34, 2010. ​​​​​

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​Yoash  Hassidim,  Ofer  Prager,  Ilan  Shelf  and  Alon  Friedman. 2012.  Assessment  of  Blood-brain barrier breakdown. In:  Animal Models of Acute Neurological Injuries. Jun Chen, Xio-Ming Xu, Zao C. Xu and John H. Zhang  (Eds.) Humana Press, Colune 1, pp. 401-5.​​​​​

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​Alon  Friedman  and  Mireille  Lerner-Natoli.  2012.  Targtes  for  antiepileptogenesis:  blood-brain barrier  and  angiogenesis.  Therapeutic  targets  and  perspectives  in  the  pharmacological  treatment of epilepsy. Editor: Holger Lerche and Heidrun Potschka. UNI-MED Science.​​​​