Our main interest is in developing novel "ideal" transformations, meaning the formation of a target molecule in a single synthetic operation from readily available starting materials, in 100% yield and without side-product formation. The synthesis should be simple, safe, economically acceptable and environmentally friendly.
One of the projects, that we are excited to work on, is the development of new techniques for the preparation of complex phenolic architectures directly from simple phenols. These methods, based on iron catalysis, allow the direct coupling of phenols with different substrates under oxidation conditions.
In many cases, these reactions result in the formation of complex structures, whose preparation previously required several synthetic steps. Based on our new developments, important bioactive target molecules, such as coumestrol, are being prepared in a timely and sustainable manner, starting from simple and commercially available starting materials.