The Faculty of Natural Sciences was established in 1970 and includes six departments: Mathematics, Computer Science,  Physics, Chemistry, Life Sciences, and Earth & Environmental Sciences. All six departments offer B.Sc., M.Sc. and Ph.D. study programs.​

The Faculty employs over 145 academic faculty members, and has approximately 1,900 undergraduate and 
500 graduate students. In addition to its core activities, including interdepartmental and inter-faculty studies for both Undergraduate and Graduate degrees, the Faculty also provides training in all applied sciences, and offers courses in mathematics and basic sciences for the full-time equivalent of over 2,000 students majoring in engineering, medical and social sciences.

The Faculty sees itself as fulfilling a two fold purpose: basic scientific and advanced educational and research training of Israel’s future scientists, creating a human infrastructure of the highest standard for the industrial and applied scientific requirements of the Negev and State of Israel; and the pursuit of scholarly research, basic and applied, in the disciplines of mathematics and natural sciences.
Natural sciences are the basis of many of the study programs at BGU.  As part of BGU’s educational mission and as a basis for research the Faculty strives to provide a means for students to develop an understanding in natural sciences, and to educate scholars with a deep knowledge and understanding of the different related disciplines. We aim to develop independent, critical awareness and systematic research abilities in our students so as to create a new generation of researchers.  The undergraduate study programs include also several interdisciplinary programs aimed to provide excelling students with a rich platform for scientific, technological and social changes.
The Faculty of Natural Sciences continuously strives for excellence in research. The theoretical and experimental, basic and applied research programs undertaken in the Faculty have direct relevance to development of the Negev, Israel’s southern desert. Sophisticated, state-of-the-art laboratories have been painstakingly built up, and although far from complete, contain equipment vital to the development of this region. The spectrum of scientific endeavor at the Faculty of Natural Sciences ranges from computer science to biotechnology; from polymers to lasers. High-tech industrial applications in electronics, computers and electro-optics, and transformation of the natural resources of the Negev into the modern industrial powerhouse of the state are actively pursued. The Faculty of Natural Sciences provides knowledge and expert services and serves as an incubator for high technology developments and the successful absorption of new immigrant scientists. It also trains science teachers for secondary schools and qualified personnel for local industry, government and health service laboratories.
The Faculty thus not only functions as a training ground for expert manpower, but is simultaneously pushing forward the frontiers of the desert while advancing those of science. 
 - Research is at the very heart of the Faculty of Natural Sciences activities. This includes:
  •  - Main emphasis on graduate and postgraduate research
  •  - Post-doctoral training
  •  - Extensive list of publications
  •  - The very best publication venues
  •  - Competitive research grants
  •  - Alon fellowships, ERC and Human Frontiers granted by young faculty  
  •  - International scientific meetings
  •  - Faculty serving on national and international committees and scientific bodies