Research interest:

Understanding the kinetics and the 3D organization of protein complexes in cells is key to understanding cellular mechanisms. We use a state-of-the-art fluorescence light microscopy techniques including super resolution microscopy and quantitative live cells imaging to generate a spatiotemporal map of protein complexes in cells in order to unravel their mechanism of action. We are currently focusing on understanding the underlying mechanism for membrane bending and fission mediated by the ESCRT multi-protein complex and in mechanisms for cell division.

Elia N, Ott C, Lippincott-Schwartz J. (2013) Incisive imaging and computation for cellular mysteries: lessons from abscission. Cell 155(6) 1220-31.

Goliand I, Nachmias D, Elia N. (2014) Inhibition of ESCRT II- CHMP6 interaction impedes cytokinetic abscission and leads to cell death. Mol Biol Cell. 15;25(23):3740-8

Gershony O, Noach M, Elia N, Tzur A. (2014) Cytokinetic abscission is an acute G1 event. Cell Cycle 13(21):3436-41

Sherman S, Nachmias D, Elia N. (2015) A simple, straightforward correlative live-cell-imaging-structured-illumination-microscopy approach for studying organelle dynamics. Microsc Res Tech. 78(9):777-83.

Sherman S, Kirchenbuechler D, Nachmias D, Tamir A, Werner S, Elbaum M, Elia N. (2016) Resolving new ultrastructural features of cytokinetic abscission with soft-X-ray cryo-tomography. Sci Rep. 10;6:27629.

PhD The Hebrew University of Jerusalem, 2007