The Shraga Segal Department of Microbiology and Immunology Publications

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Publications 2021

R. Solomon, A. AbuMadighem, J. Kapelushnik, B. C. Amano, E. Lunenfeld and M. Huleihel (2021) Involvement of Cytokines and Hormones in the Development of Spermatogenesis In Vitro from Spermatogonial Cells of Cyclophosphamide-Treated Immature Mice Int J Mol Sci https://www.ncbi.nlm.nih.gov/pubmed/33562323

V. Bhingardive, G. Le Saux, A. Edri, A. Porgador and M. Schvartzman (2021) Nanowire Based Guidance of the Morphology and Cytotoxic Activity of Natural Killer Cells Small https://www.ncbi.nlm.nih.gov/pubmed/33719212

O. Mann, D. Peery, R. Bader Segev, S. Klainbart, E. Kelmer, A. Sobarzo, V. Shub, K. Rapoport, M. H. Shamir and O. Chai (2021) CT findings and the prognostic value of the Koret CT score in cats with traumatic brain injury J Feline Med Surg https://www.ncbi.nlm.nih.gov/pubmed/33847537

R. Malishev, S. Ben-Zichri, O. Oren, N. Shauloff, T. Peretz, R. Taube, N. Papo and R. Jelinek (2021) The pro-apoptotic domain of BIM protein forms toxic amyloid fibrils Cell Mol Life Sci https://www.ncbi.nlm.nih.gov/pubmed/32844279

E. N. Alsahafi, S. Thavaraj, N. Sarvestani, O. Novoplansky, M. Elkabets, B. Ayaz, M. Tavassoli and M. F. Legends (2021) EGFR overexpression increases radiotherapy response in HPV-positive head and neck cancer through inhibition of DNA damage repair and HPV E6 downregulation Cancer Lett https://www.ncbi.nlm.nih.gov/pubmed/33137407

O. Wormser, Y. Levy, A. Bakhrat, S. Bonaccorsi, L. Graziadio, M. Gatti, A. AbuMadighem, R. J. McKenney, K. Okada, S. El Riati, I. Har-Vardi, M. Huleihel, E. Levitas, O. S. Birk and U. Abdu (2021) Absence of SCAPER causes male infertility in humans and Drosophila by modulating microtubule dynamics during meiosis J Med Genet https://www.ncbi.nlm.nih.gov/pubmed/32527956

Z. Vitic, H. Safory, V. M. Jovanovic, Y. Sarusi, A. Stavsky, J. Kahn, A. Kuzmina, L. Toker, D. Gitler, R. Taube, R. H. Friedel, S. Engelender and C. Brodski (2021) BMP5/7 protect dopaminergic neurons in an alpha-synuclein mouse model of Parkinson's disease Brain https://www.ncbi.nlm.nih.gov/pubmed/33253359

A. Sawaied, E. Arazi, A. AbuElhija, E. Lunenfeld and M. Huleihel (2021) The Presence of Colony-Stimulating Factor-1 and Its Receptor in Different Cells of the Testis; It Involved in the Development of Spermatogenesis In Vitro Int J Mol Sci https://www.ncbi.nlm.nih.gov/pubmed/33652607

A. Ottolenghi, P. Bolel, R. Sarkar, Y. Greenshpan, M. Iraqi, S. Ghosh, B. Bhattacharya, Z. V. Taylor, K. Kundu, O. Radinsky, R. Gazit, D. Stepensky, R. N. Apte, E. Voronov and A. Porgador (2021) Life-extended glycosylated IL-2 promotes Treg induction and suppression of autoimmunity Sci Rep https://www.ncbi.nlm.nih.gov/pubmed/33828163

L. Olender, K. Levy and R. Gazit (2021) Method for the Generation of Induced Hematopoietic Stem Cells Methods Mol Biol https://www.ncbi.nlm.nih.gov/pubmed/33165863

S. Naveh Tassa, S. Ben Zichri, S. Lacham-Hartman, O. Oren, Z. Slobodnik, E. Eremenko, D. Toiber, R. Jelinek and N. Papo (2021) A Mechanism for the Inhibition of Tau Neurotoxicity: Studies with Artificial Membranes, Isolated Mitochondria, and Intact Cells ACS Chem Neurosci https://www.ncbi.nlm.nih.gov/pubmed/33904703

A. Muraleedharan, N. Rotem-Dai, I. Strominger, N. P. Anto, N. Isakov, A. Monsonego and E. Livneh (2021) Protein kinase C eta is activated in reactive astrocytes of an Alzheimer's disease mouse model: Evidence for its immunoregulatory function in primary astrocytes Glia https://www.ncbi.nlm.nih.gov/pubmed/33068318

L. Mordechay, G. Le Saux, A. Edri, U. Hadad, A. Porgador and M. Schvartzman (2021) Mechanical Regulation of the Cytotoxic Activity of Natural Killer Cells ACS Biomater Sci Eng https://www.ncbi.nlm.nih.gov/pubmed/33455204

A. Kuzmina, Y. Khalaila, O. Voloshin, A. Keren-Naus, L. Boehm-Cohen, Y. Raviv, Y. Shemer-Avni, E. Rosenberg and R. Taube (2021) SARS-CoV-2 spike variants exhibit differential infectivity and neutralization resistance to convalescent or post-vaccination sera Cell host & microbe https://www.ncbi.nlm.nih.gov/pubmed/33789085

A. Y. Kulaga, E. Ursu, D. Toren, V. Tyshchenko, R. Guinea, M. Pushkova, V. E. Fraifeld and R. Tacutu (2021) Machine Learning Analysis of Longevity-Associated Gene Expression Landscapes in Mammals Int J Mol Sci https://www.ncbi.nlm.nih.gov/pubmed/33499037

S. Krasnopolsky, A. Novikov, A. Kuzmina and R. Taube (2021) CRISPRi-mediated depletion of Spt4 and Spt5 reveals a role for DSIF in the control of HIV latency Biochim Biophys Acta Gene Regul Mech https://www.ncbi.nlm.nih.gov/pubmed/33333262

M. Kowarsky, C. Anselmi, K. Hotta, P. Burighel, G. Zaniolo, F. Caicci, B. Rosental, N. F. Neff, K. J. Ishizuka, K. J. Palmeri, J. Okamoto, T. Gordon, I. L. Weissman, S. R. Quake, L. Manni and A. Voskoboynik (2021) Sexual and asexual development: two distinct programs producing the same tunicate Cell Rep https://www.ncbi.nlm.nih.gov/pubmed/33503429

J. K. Kim, M. R. Marco, S. H. Choi, X. Qu, C. T. Chen, M. Elkabets, L. Fairchild, O. Chow, F. M. Barriga, L. E. Dow, K. O'Rourke, B. Szeglin, D. Yarilin, S. Fujisawa, K. Manova-Todorova, P. B. Paty, J. Shia, C. Leslie, J. J. Smith, S. Lowe, R. Pelossof, F. Sanchez-Vega and J. Garcia-Aguilar (2021) KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix Mol Oncol https://www.ncbi.nlm.nih.gov/pubmed/33817986

N. Keinan, Y. Scharff, O. Goldstein, M. Chamo, S. Ilic and R. Gazit (2021) Syngeneic leukemia models using lentiviral transgenics Cell Death Dis https://www.ncbi.nlm.nih.gov/pubmed/33602907

G. Jenia, B. Dor and S. M. Neta (2021) Transmembrane domains of type III-secreted proteins affect bacterial-host interactions in enteropathogenic E. coli Virulence https://www.ncbi.nlm.nih.gov/pubmed/33729090

O. Hassin, Y. Abu Freih, R. Hazan, A. Lev, K. S. Zrihen, R. Somech, A. Broides and A. Nahum (2021) Trough Concentrations of Specific Antibodies in Primary Immunodeficiency Patients Receiving Intravenous Immunoglobulin Replacement Therapy J Clin Med https://www.ncbi.nlm.nih.gov/pubmed/33557365

Y. Greenshpan, O. Sharabi, A. Ottolenghi, A. Cahana, K. Kundu, M. Y. K, M. Elkabets, R. Gazit and A. Porgador (2021) Synthetic promoters to induce immune-effectors into the tumor microenvironment Commun Biol https://www.ncbi.nlm.nih.gov/pubmed/33514819

I. Godwin, N. P. Anto, S. V. Bava, M. S. Babu and G. G. Jinesh (2021) Targeting K-Ras and apoptosis-driven cellular transformation in cancer Cell Death Discov https://www.ncbi.nlm.nih.gov/pubmed/33854056

Y. Faingelernt, E. Hershkovitz, B. Abu-Libdeh, A. Abedrabbo, S. Abu-Rmaileh Amro, R. Zarivach, D. Zangen, E. Lavi, A. Haim, R. Parvari and A. Abu-Libdeh (2021) Aldosterone synthase (CYP11B2) deficiency among Palestinian infants: Three novel variants and genetic heterogeneity Am J Med Genet A https://www.ncbi.nlm.nih.gov/pubmed/33438832

Y. Elyahu and A. Monsonego (2021) Thymus involution sets the clock of the aging T-cell landscape: Implications for declined immunity and tissue repair Ageing Res Rev https://www.ncbi.nlm.nih.gov/pubmed/33248315

M. Elkabets and G. Blandino (2021) Jose Baselga M.D., Ph.D. (1959-2021) leading cancer researcher and oncologist J Exp Clin Cancer Res https://www.ncbi.nlm.nih.gov/pubmed/33962670

E. David, M. Wolfson and V. E. Fraifeld (2021) Background radiation impacts human longevity and cancer mortality: reconsidering the linear no-threshold paradigm Biogerontology https://www.ncbi.nlm.nih.gov/pubmed/33479810

I. Cohen, C. Bar, H. Liu, V. J. Valdes, D. Zhao, P. M. Galbo, Jr., J. M. Silva, H. Koseki, D. Zheng and E. Ezhkova (2021) Polycomb complexes redundantly maintain epidermal stem cell identity during development Genes Dev https://www.ncbi.nlm.nih.gov/pubmed/33602871

J. Bouaoud, G. De Souza, C. Darido, A. Tortereau, M. Elkabets, C. Bertolus and P. Saintigny (2021) The 4-NQO mouse model: An update on a well-established in vivo model of oral carcinogenesis Methods Cell Biol https://www.ncbi.nlm.nih.gov/pubmed/33785166

Publications 2020

Z. Vershinin, M. Feldman and D. Levy (2020) PAK4 methylation by the methyltransferase SETD6 attenuates cell adhesion Sci Rep https://www.ncbi.nlm.nih.gov/pubmed/33051544

D. Toren, A. Kulaga, M. Jethva, E. Rubin, A. V. Snezhkina, A. V. Kudryavtseva, D. Nowicki, R. Tacutu, A. A. Moskalev and V. E. Fraifeld (2020) Gray whale transcriptome reveals longevity adaptations associated with DNA repair and ubiquitination Aging cell https://www.ncbi.nlm.nih.gov/pubmed/32515539

T. Tilayov, T. Hingaly, Y. Greenshpan, S. Cohen, B. Akabayov, R. Gazit and N. Papo (2020) Engineering Stem Cell Factor Ligands with Different c-Kit Agonistic Potencies Molecules https://www.ncbi.nlm.nih.gov/pubmed/33096693

O. Staretz-Chacham, L. Schlotawa, O. Wormser, I. Golan-Tripto, O. S. Birk, C. R. Ferreira, T. Dierks and K. Radhakrishnan (2020) A homozygous missense variant of SUMF1 in the Bedouin population extends the clinical spectrum in ultrarare neonatal multiple sulfatase deficiency Mol Genet Genomic Med https://www.ncbi.nlm.nih.gov/pubmed/32048457

G. A. Snyder, W. E. Browne, N. Traylor-Knowles and B. Rosental (2020) Fluorescence-Activated Cell Sorting for the Isolation of Scleractinian Cell Populations J Vis Exp https://www.ncbi.nlm.nih.gov/pubmed/32538898

O. Furman, L. Shenhav, G. Sasson, F. Kokou, H. Honig, S. Jacoby, T. Hertz, O. X. Cordero, E. Halperin and I. Mizrahi (2020) Stochasticity constrained by deterministic effects of diet and age drive rumen microbiome assembly dynamics Nat Commun https://www.ncbi.nlm.nih.gov/pubmed/32312972

A. Levitas, E. Muhammad, Y. Zhang, I. Perea Gil, R. Serrano, N. Diaz, M. Arafat, A. A. Gavidia, M. S. Kapiloff, M. Mercola, Y. Etzion, R. Parvari and I. Karakikes (2020) A Novel Recessive Mutation in SPEG Causes Early Onset Dilated Cardiomyopathy PLoS Genet https://www.ncbi.nlm.nih.gov/pubmed/32925938

H. D. Ravkin, O. Givton, D. B. Geffen and E. Rubin (2020) Direct comparison shows that mRNA-based diagnostics incorporate information which cannot be learned directly from genomic mutations BMC Bioinformatics https://www.ncbi.nlm.nih.gov/pubmed/32429832

M. Prasad, S. Jagadeeshan, M. Scaltriti, I. Allon and M. Elkabets (2020) In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System J Vis Exp https://www.ncbi.nlm.nih.gov/pubmed/31984965

T. Powrozek, A. Porgador and T. Malecka-Massalska (2020) Detection, prediction, and prognosis: blood circulating microRNA as novel molecular markers of head and neck cancer patients Expert Rev Mol Diagn https://www.ncbi.nlm.nih.gov/pubmed/31778325

B. Bhatta and T. Cooks (2020) Reshaping the tumor microenvironment: extracellular vesicles as messengers of cancer cells Carcinogenesis https://www.ncbi.nlm.nih.gov/pubmed/33047121

O. Pikovsky, M. Arafat, H. Ovadia, Y. Sharoni, K. Al-Athamen, B. Kanengisser-Pines, A. Keren-Politansky, I. Levi, O. Erez, R. Parvari and A. Rabinovich (2020) Congenital thrombotic thrombocytopenic purpura in a large cohort of patients carrying a novel mutation in ADAMTS13 gene Thromb Res https://www.ncbi.nlm.nih.gov/pubmed/31837614

L. Olender, N. Bujanover, O. Sharabi, O. Goldstein and R. Gazit (2020) Cyclosporine H Improves the Multi-Vector Lentiviral Transduction of Murine Haematopoietic Progenitors and Stem Cells Sci Rep https://www.ncbi.nlm.nih.gov/pubmed/32020016

N. Nandakumar, P. Gopinath, J. Gopas and K. M. Muraleedharan (2020) Benzisothiazolone Derivatives Exhibit Cytotoxicity in Hodgkin's Lymphoma Cells through NF-kappaB Inhibition and are Synergistic with Doxorubicin and Etoposide Anticancer Agents Med Chem https://www.ncbi.nlm.nih.gov/pubmed/32053083

D. A. Tolstun, A. Knyazer, T. V. Tushynska, T. A. Dubiley, V. V. Bezrukov, V. E. Fraifeld and K. K. Muradian (2020) Metabolic remodelling of mice by hypoxic-hypercapnic environment: imitating the naked mole-rat Biogerontology https://www.ncbi.nlm.nih.gov/pubmed/31667660

A. Nahum, R. Somech, G. Shubinsky, J. Levy and A. Broides (2020) Unusual phenotype in patients with a hypomorphic mutation in the DCLRE1C gene: IgG hypergammaglobulinemia with IgA and IgE deficiency Clin Immunol https://www.ncbi.nlm.nih.gov/pubmed/32092471

N. Abu Freha, T. Wainstock, L. Poupko, A. Yonat Shemer, R. Sergienko and E. Sheiner (2020) Maternal hepatitis B or hepatitis C virus carrier status and long-term infectious morbidity of the offspring: A population-based cohort study J Viral Hepat https://www.ncbi.nlm.nih.gov/pubmed/32274882

N. Levhar, B. Ungar, U. Kopylov, E. Fudim, M. Yavzori, O. Picard, N. Amariglio, Y. Chowers, Y. Shemer-Avni, R. Mao, M. H. Chen, Z. Ye, R. Eliakim and S. Ben-Horin (2020) Propagation of EBV-driven Lymphomatous Transformation of Peripheral Blood B Cells by Immunomodulators and Biologics Used in the Treatment of Inflammatory Bowel Disease Inflamm Bowel Dis https://www.ncbi.nlm.nih.gov/pubmed/32322878

S. Krasnopolsky, A. Kuzmina and R. Taube (2020) Genome-wide CRISPR knockout screen identifies ZNF304 as a silencer of HIV transcription that promotes viral latency PLoS Pathog https://www.ncbi.nlm.nih.gov/pubmed/32956422

Y. Koren Carmi, H. Mahmoud, H. Khamaisi, R. Adawi, J. Gopas and J. Mahajna (2020) Flavonoids Restore Platinum Drug Sensitivity to Ovarian Carcinoma Cells in a Phospho-ERK1/2-Dependent Fashion Int J Mol Sci https://www.ncbi.nlm.nih.gov/pubmed/32906729

A. Katiyi, J. Zorea, A. Halstuch, M. Elkabets and A. Karabchevsky (2020) Surface roughness-induced absorption acts as an ovarian cancer cells growth sensor-monitor Biosensors & bioelectronics https://www.ncbi.nlm.nih.gov/pubmed/32365013

A. Sawaied, E. Lunenfeld and M. Huleihel (2020) Interleukin-34, a Novel Paracrine/Autocrine Factor in Mouse Testis, and Its Possible Role in the Development of Spermatogonial Cells In Vitro Int J Mol Sci https://www.ncbi.nlm.nih.gov/pubmed/33143373

M. Iraqi, A. Edri, Y. Greenshpan, K. Kundu, P. Bolel, A. Cahana, A. Ottolenghi, R. Gazit, L. Lobel, A. Braiman and A. Porgador (2020) N-Glycans Mediate the Ebola Virus-GP1 Shielding of Ligands to Immune Receptors and Immune Evasion Frontiers in cellular and infection microbiology https://www.ncbi.nlm.nih.gov/pubmed/32211339

M. Huleihel and E. Lunenfeld (2020) Approaches and Technologies in Male Fertility Preservation Int J Mol Sci https://www.ncbi.nlm.nih.gov/pubmed/32751826

N. Goldstein, Y. Kezerle, Y. Gepner, Y. Haim, T. Pecht, R. Gazit, V. Polischuk, I. F. Liberty, B. Kirshtein, R. Shaco-Levy, M. Bluher and A. Rudich (2020) Higher Mast Cell Accumulation in Human Adipose Tissues Defines Clinically Favorable Obesity Sub-Phenotypes Cells https://www.ncbi.nlm.nih.gov/pubmed/32575785

I. Cohen, C. Bar and E. Ezhkova (2020) Activity of PRC1 and Histone H2AK119 Monoubiquitination: Revising Popular Misconceptions Bioessays https://www.ncbi.nlm.nih.gov/pubmed/32196702

E. Cocco, J. E. Lee, S. Kannan, A. M. Schram, H. H. Won, S. Shifman, A. Kulick, L. Baldino, E. Toska, A. Arruabarrena-Aristorena, S. Kittane, F. Wu, Y. Cai, S. Arena, B. Mussolin, R. Kannan, N. Vasan, A. N. Gorelick, M. F. Berger, O. Novoplansky, S. Jagadeeshan, Y. Liao, U. Rix, S. Misale, B. S. Taylor, A. Bardelli, J. F. Hechtman, D. M. Hyman, M. Elkabets, E. de Stanchina, C. S. Verma, A. Ventura, A. Drilon and M. Scaltriti (2020) TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors Cancer Discov https://www.ncbi.nlm.nih.gov/pubmed/33004339

G. Bunu, D. Toren, C. F. Ion, D. Barardo, L. Sarghie, L. G. Grigore, J. P. de Magalhaes, V. E. Fraifeld and R. Tacutu (2020) SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes Sci Data https://www.ncbi.nlm.nih.gov/pubmed/33106474

J. Zorea, R. P. Shukla, M. Elkabets and H. Ben-Yoav (2020) Probing antibody surface density and analyte antigen incubation time as dominant parameters influencing the antibody-antigen recognition events of a non-faradaic and diffusion-restricted electrochemical immunosensor Anal Bioanal Chem https://www.ncbi.nlm.nih.gov/pubmed/31996962

A. Zeadna, N. Khateeb, L. Rokach, Y. Lior, I. Har-Vardi, A. Harlev, M. Huleihel, E. Lunenfeld and E. Levitas (2020) Prediction of sperm extraction in non-obstructive azoospermia patients: a machine-learning perspective Hum Reprod https://www.ncbi.nlm.nih.gov/pubmed/32538428

K. M. Yegodayev, O. Novoplansky, A. Golden, M. Prasad, L. Levin, S. Jagadeeshan, J. Zorea, O. Dimitstein, B. Z. Joshua, L. Cohen, E. Khrameeva and M. Elkabets (2020) TGF-Beta-Activated Cancer-Associated Fibroblasts Limit Cetuximab Efficacy in Preclinical Models of Head and Neck Cancer Cancers (Basel) https://www.ncbi.nlm.nih.gov/pubmed/32028632

E. E. Azulay, T. Cooks and M. Elkabets (2020) Potential oncogenic roles of mutant-p53-derived exosomes in the tumor-host interaction of head and neck cancers Cancer Immunol Immunother https://www.ncbi.nlm.nih.gov/pubmed/31897662

R. A. Avelar, J. G. Ortega, R. Tacutu, E. J. Tyler, D. Bennett, P. Binetti, A. Budovsky, K. Chatsirisupachai, E. Johnson, A. Murray, S. Shields, D. Tejada-Martinez, D. Thornton, V. E. Fraifeld, C. L. Bishop and J. P. de Magalhaes (2020) A multidimensional systems biology analysis of cellular senescence in aging and disease Genome Biol https://www.ncbi.nlm.nih.gov/pubmed/32264951

M. Arafat, A. Zeadna, E. Levitas, I. Har Vardi, B. Samueli, R. Shaco-Levy, S. Dabsan, E. Lunenfeld, M. Huleihel and R. Parvari (2020) Novel mutation in USP26 associated with azoospermia in a Sertoli cell-only syndrome patient Mol Genet Genomic Med https://www.ncbi.nlm.nih.gov/pubmed/32410375

M. Arafat, A. Harlev, I. Har-Vardi, E. Levitas, T. Priel, M. Gershoni, C. Searby, V. C. Sheffield, E. Lunenfeld and R. Parvari (2020) Mutation in CATIP (C2orf62) causes oligoteratoasthenozoospermia by affecting actin dynamics J Med Genet https://www.ncbi.nlm.nih.gov/pubmed/32503832

S. M. Janssen, R. Moscona, M. Elchebly, A. I. Papadakis, M. Redpath, H. Wang, E. Rubin, L. C. van Kempen and A. Spatz (2020) BORIS/CTCFL promotes a switch from a proliferative towards an invasive phenotype in melanoma cells Cell Death Discov https://www.ncbi.nlm.nih.gov/pubmed/32123577

O. Oren, S. Ben Zichri, R. Taube, R. Jelinek and N. Papo (2020) Abeta42 Double Mutant Inhibits Abeta42-Induced Plasma and Mitochondrial Membrane Disruption in Artificial Membranes, Isolated Organs, and Intact Cells ACS Chem Neurosci https://www.ncbi.nlm.nih.gov/pubmed/32155047

B. Rosental, T. Raveh, A. Voskoboynik and I. L. Weissman (2020) Evolutionary perspective on the hematopoietic system through a colonial chordate: allogeneic immunity and hematopoiesis Curr Opin Immunol https://www.ncbi.nlm.nih.gov/pubmed/31954962

A. Rokas, S. Mesiano, O. Tamam, A. LaBella, G. Zhang and L. Muglia (2020) Developing a theoretical evolutionary framework to solve the mystery of parturition initiation Elife https://www.ncbi.nlm.nih.gov/pubmed/33380346

N. M. Rijensky, N. R. Blondheim Shraga, E. Barnea, N. Peled, E. Rosenbaum, A. Popovtzer, S. M. Stemmer, A. Livoff, M. Shlapobersky, N. Moskovits, D. Perry, E. Rubin, I. Haviv and A. Admon (2020) Identification of Tumor Antigens in the HLA Peptidome of Patient-derived Xenograft Tumors in Mouse Mol Cell Proteomics https://www.ncbi.nlm.nih.gov/pubmed/32451349

E. Remer, M. Badarni, E. Hikri, A. Dayan, L. Levi, A. Popovtzer, M. Iraqi, A. Porgador, B. Z. Joshua, G. Bachar, M. Elkabets, M. Scaltriti and A. Mizrachi (2020) CDK 4/6 Inhibition Overcomes Acquired and Inherent Resistance to PI3Kalpha Inhibition in Pre-Clinical Models of Head and Neck Squamous Cell Carcinoma J Clin Med https://www.ncbi.nlm.nih.gov/pubmed/33036331

Publications 2019

N. Baruch-Eliyahu, V. Rud, A. Braiman and E. Priel (2019) Telomerase increasing compound protects hippocampal neurons from amyloid beta toxicity by enhancing the expression of neurotrophins and plasticity related genes Sci Rep https://www.ncbi.nlm.nih.gov/pubmed/31792359

H. Yin, H. Ma, S. Hussain, H. Zhang, X. Xie, L. Jiang, X. Jiang, F. Iqbal, I. Bukhari, H. Jiang, A. Ali, L. Zhong, T. Li, S. Fan, B. Zhang, J. Gao, Y. Li, J. Nazish, T. Khan, M. Khan, M. Zubair, Q. Hao, H. Fang, J. Huang, M. Huleihel, J. Sha, T. K. Pandita, Y. Zhang and Q. Shi (2019) A homozygous FANCM frameshift pathogenic variant causes male infertility Genet Med https://www.ncbi.nlm.nih.gov/pubmed/29895858

H. Yin, H. Ma, S. Hussain, H. Zhang, X. Xie, L. Jiang, X. Jiang, F. Iqbal, I. Bukhari, H. Jiang, A. Ali, L. Zhong, T. Li, S. Fan, B. Zhang, J. Gao, Y. Li, J. Nazish, T. Khan, M. Khan, M. Zubair, Q. Hao, H. Fang, J. Huang, M. Huleihel, J. Sha, T. K. Pandita, Y. Zhang and Q. Shi (2019) Correction: A homozygous FANCM frameshift pathogenic variant causes male infertility Genet Med https://www.ncbi.nlm.nih.gov/pubmed/30158692

R. Yahalom, D. Barishev, A. Steren, Y. Nameri, M. Roytman, A. Porgador and Y. Elovici (2019) Datasets of RT spoofing attacks on MIL-STD-1553 communication traffic Data in brief https://www.ncbi.nlm.nih.gov/pubmed/31372474

M. Varon, T. Levy, G. Mazor, H. Ben David, R. Marciano, Y. Krelin, M. Prasad, M. Elkabets, D. Pauck, U. Ahmadov, D. Picard, N. Qin, A. Borkhardt, G. Reifenberger, G. Leprivier, M. Remke and B. Rotblat (2019) The long noncoding RNA TP73-AS1 promotes tumorigenicity of medulloblastoma cells Int J Cancer https://www.ncbi.nlm.nih.gov/pubmed/31081944

H. Valli-Pulaski, K. A. Peters, K. Gassei, S. R. Steimer, M. Sukhwani, B. P. Hermann, L. Dwomor, S. David, A. P. Fayomi, S. K. Munyoki, T. Chu, R. Chaudhry, G. M. Cannon, P. J. Fox, T. M. Jaffe, J. S. Sanfilippo, M. N. Menke, E. Lunenfeld, M. Abofoul-Azab, L. S. Sender, J. Messina, L. M. Klimpel, Y. Gosiengfiao, E. E. Rowell, M. H. Hsieh, C. F. Granberg, P. P. Reddy, J. I. Sandlow, M. Huleihel and K. E. Orwig (2019) Testicular tissue cryopreservation: 8 years of experience from a coordinated network of academic centers Hum Reprod https://www.ncbi.nlm.nih.gov/pubmed/31111889

I. Tseytin, B. Mitrovic, N. David, K. Langenfeld, R. Zarivach, A. Diepold and N. Sal-Man (2019) The Role of the Small Export Apparatus Protein, SctS, in the Activity of the Type III Secretion System Front Microbiol https://www.ncbi.nlm.nih.gov/pubmed/31798543

O. Staretz-Chacham, O. Wormser, E. Manor, O. S. Birk and C. R. Ferreira (2019) TMEM70 deficiency: Novel mutation and hypercitrullinemia during metabolic decompensation Am J Med Genet A https://www.ncbi.nlm.nih.gov/pubmed/30950220

I. S. Pateras and T. Cooks (2019) Determination of Polarization of Resident Macrophages and Their Effect on the Tumor Microenvironment Methods Mol Biol https://www.ncbi.nlm.nih.gov/pubmed/30725453

P. Pandya, R. Pasvolsky, Y. Babichev, A. Braiman, S. Witte, A. Altman and N. Isakov (2019) PICOT binding to the polycomb group protein, EED, alters H3K27 methylation at the MYT1 PRC2 target gene Biochem Biophys Res Commun https://www.ncbi.nlm.nih.gov/pubmed/30595380

P. Pandya, M. Jethva, E. Rubin, R. Y. Birnbaum, A. Braiman and N. Isakov (2019) PICOT binding to chromatin-associated EED negatively regulates cyclin D2 expression by increasing H3K27me3 at the CCND2 gene promoter Cell Death Dis https://www.ncbi.nlm.nih.gov/pubmed/31527584

P. Pandya, A. Braiman and N. Isakov (2019) PICOT (GLRX3) is a positive regulator of stress-induced DNA-damage response Cell Signal https://www.ncbi.nlm.nih.gov/pubmed/31176019

O. Novoplansky, M. Fury, M. Prasad, K. Yegodayev, J. Zorea, L. Cohen, R. Pelossof, L. Cohen, N. Katabi, F. Cecchi, B. Z. Joshua, A. Popovtzer, J. Baselga, M. Scaltriti and M. Elkabets (2019) MET activation confers resistance to cetuximab, and prevents HER2 and HER3 upregulation in head and neck cancer Int J Cancer https://www.ncbi.nlm.nih.gov/pubmed/30694565

V. Myrianthopoulos, K. Evangelou, P. V. S. Vasileiou, T. Cooks, T. P. Vassilakopoulos, G. A. Pangalis, M. Kouloukoussa, C. Kittas, A. G. Georgakilas and V. G. Gorgoulis (2019) Senescence and senotherapeutics: a new field in cancer therapy Pharmacology & therapeutics https://www.ncbi.nlm.nih.gov/pubmed/30121319

W. Mulla, B. Hajaj, S. Elyagon, M. Mor, R. Gillis, M. Murninkas, H. Klapper-Goldstein, I. Plaschkes, V. Chalifa-Caspi, S. Etzion and Y. Etzion (2019) Rapid Atrial Pacing Promotes Atrial Fibrillation Substrate in Unanesthetized Instrumented Rats Front Physiol https://www.ncbi.nlm.nih.gov/pubmed/31616316

Y. Michailov, E. Lunenfeld, J. Kapilushnik, S. Friedler, E. Meese and M. Huleihel (2019) Acute Myeloid Leukemia Affects Mouse Sperm Parameters, Spontaneous Acrosome Reaction, and Fertility Capacity Int J Mol Sci https://www.ncbi.nlm.nih.gov/pubmed/30626098

Y. Michailov, E. Lunenfeld, J. Kapelushnik and M. Huleihel (2019) Leukemia and male infertility: past, present, and future Leuk Lymphoma https://www.ncbi.nlm.nih.gov/pubmed/30501544

R. Marciano, M. Prasad, T. Ievy, S. Tzadok, G. Leprivier, M. Elkabets and B. Rotblat (2019) High-Throughput Screening Identified Compounds Sensitizing Tumor Cells to Glucose Starvation in Culture and VEGF Inhibitors In Vivo Cancers (Basel) https://www.ncbi.nlm.nih.gov/pubmed/30704052

D. Levy (2019) Lysine methylation signaling of non-histone proteins in the nucleus Cell Mol Life Sci https://www.ncbi.nlm.nih.gov/pubmed/31123776

G. Le Saux, N. Bar-Hanin, A. Edri, U. Hadad, A. Porgador and M. Schvartzman (2019) Nanoscale Mechanosensing of Natural Killer Cells is Revealed by Antigen-Functionalized Nanowires Adv Mater https://www.ncbi.nlm.nih.gov/pubmed/30488552

K. Kundu, S. Ghosh, R. Sarkar, A. Edri, M. Brusilovsky, O. Gershoni-Yahalom, R. Yossef, A. Shemesh, J. C. Soria, V. Lazar, B. Z. Joshua, K. S. Campbell, M. Elkabets and A. Porgador (2019) Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA Cancer Immunol Res https://www.ncbi.nlm.nih.gov/pubmed/31164357

J. H. Kuhn, T. Adachi, N. K. J. Adhikari, J. R. Arribas, I. E. Bah, D. G. Bausch, N. Bhadelia, M. Borchert, A. B. Brantsaeter, D. M. Brett-Major, T. H. Burgess, D. S. Chertow, C. G. Chute, T. J. Cieslak, R. Colebunders, I. Crozier, R. T. Davey, H. de Clerck, R. Delgado, L. Evans, M. Fallah, W. A. Fischer, 2nd, T. E. Fletcher, R. A. Fowler, T. Grunewald, A. Hall, A. Hewlett, A. I. M. Hoepelman, C. F. Houlihan, G. Ippolito, S. T. Jacob, M. Jacobs, R. Jakob, F. A. Jacquerioz, L. Kaiser, A. C. Kalil, R. F. Kamara, J. Kapetshi, H. D. Klenk, G. Kobinger, M. G. Kortepeter, C. S. Kraft, T. Kratz, H. S. K. Bosa, M. Lado, F. Lamontagne, H. C. Lane, L. Lobel, J. Lutwama, G. M. Lyon, 3rd, M. B. F. Massaquoi, T. A. Massaquoi, A. K. Mehta, V. M. Makuma, S. Murthy, T. S. Musoke, J. J. Muyembe-Tamfum, P. Nakyeyune, C. Nanclares, M. Nanyunja, J. Nsio-Mbeta, T. O'Dempsey, J. T. Paweska, C. J. Peters, P. Piot, C. Rapp, B. Renaud, B. Ribner, P. C. Sabeti, J. S. Schieffelin, W. Slenczka, M. J. Soka, A. Sprecher, J. Strong, R. Swanepoel, T. M. Uyeki, M. van Herp, P. Vetter, D. A. Wohl, T. Wolf, A. Wolz, A. H. Wurie and Z. Yoti (2019) New filovirus disease classification and nomenclature Nat Rev Microbiol https://www.ncbi.nlm.nih.gov/pubmed/30926957

S. Krasnopolsky, L. Marom, R. A. Victor, A. Kuzmina, J. C. Schwartz, K. Fujinaga and R. Taube (2019) Fused in sarcoma silences HIV gene transcription and maintains viral latency through suppressing AFF4 gene activation Retrovirology https://www.ncbi.nlm.nih.gov/pubmed/31238957

I. Kaplanov, Y. Carmi, R. Kornetsky, A. Shemesh, G. V. Shurin, M. R. Shurin, C. A. Dinarello, E. Voronov and R. N. Apte (2019) Blocking IL-1beta reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation Proc Natl Acad Sci U S A https://www.ncbi.nlm.nih.gov/pubmed/30545915

S. Jagadeeshan, M. Prasad, S. Ortiz-Cuaran, V. Gregoire, P. Saintigny and M. Elkabets (2019) Adaptive Responses to Monotherapy in Head and Neck Cancer: Interventions for Rationale-Based Therapeutic Combinations Trends Cancer https://www.ncbi.nlm.nih.gov/pubmed/31208698

D. Halperin, R. Kadir, Y. Perez, M. Drabkin, Y. Yogev, O. Wormser, E. M. Berman, E. Eremenko, B. Rotblat, Z. Shorer, L. Gradstein, I. Shelef, R. Birk, U. Abdu, H. Flusser and O. S. Birk (2019) SEC31A mutation affects ER homeostasis, causing a neurological syndrome J Med Genet https://www.ncbi.nlm.nih.gov/pubmed/30464055

O. Gorelik, N. Levy, L. Shaulov, K. Yegodayev, M. M. Meijler and N. Sal-Man (2019) Vibrio cholerae autoinducer-1 enhances the virulence of enteropathogenic Escherichia coli Sci Rep https://www.ncbi.nlm.nih.gov/pubmed/30858454

M. Goldshtein, S. Shamir, E. Vinogradov, A. Monsonego and S. Cohen (2019) Co-assembled Ca(2+) Alginate-Sulfate Nanoparticles for Intracellular Plasmid DNA Delivery Mol Ther Nucleic Acids https://www.ncbi.nlm.nih.gov/pubmed/31003172

N. Gobshtis, M. Tfilin, V. E. Fraifeld and G. Turgeman (2019) Transplantation of mesenchymal stem cells causes long-term alleviation of schizophrenia-like behaviour coupled with increased neurogenesis Molecular psychiatry https://www.ncbi.nlm.nih.gov/pubmed/31827249

D. Gisselsson, D. Lichtenzstejn, P. Kachko, J. Karlsson, E. Manor and S. Mai (2019) Clonal evolution through genetic bottlenecks and telomere attrition: Potential threats to in vitro data reproducibility Genes Chromosomes Cancer https://www.ncbi.nlm.nih.gov/pubmed/30255964

S. Ghosh, M. Prasad, K. Kundu, L. Cohen, K. M. Yegodayev, J. Zorea, B. Z. Joshua, B. Lasry, O. Dimitstein, A. Bahat-Dinur, A. Mizrachi, V. Lazar, M. Elkabets and A. Porgador (2019) Tumor Tissue Explant Culture of Patient-Derived Xenograft as Potential Prioritization Tool for Targeted Therapy Front Oncol https://www.ncbi.nlm.nih.gov/pubmed/30723707

K. Mittal, E. Eremenko, O. Berner, Y. Elyahu, I. Strominger, D. Apelblat, A. Nemirovsky, I. Spiegel and A. Monsonego (2019) CD4 T Cells Induce A Subset of MHCII-Expressing Microglia that Attenuates Alzheimer Pathology iScience https://www.ncbi.nlm.nih.gov/pubmed/31203186

M. Feldman, Z. Vershinin, I. Goliand, N. Elia and D. Levy (2019) The methyltransferase SETD6 regulates Mitotic progression through PLK1 methylation Proc Natl Acad Sci U S A https://www.ncbi.nlm.nih.gov/pubmed/30622182

N. Ershaid, Y. Sharon, H. Doron, Y. Raz, O. Shani, N. Cohen, L. Monteran, L. Leider-Trejo, A. Ben-Shmuel, M. Yassin, M. Gerlic, A. Ben-Baruch, M. Pasmanik-Chor, R. Apte and N. Erez (2019) NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis Nat Commun https://www.ncbi.nlm.nih.gov/pubmed/31558756

E. Eremenko, K. Mittal, O. Berner, N. Kamenetsky, A. Nemirovsky, Y. Elyahu and A. Monsonego (2019) BDNF-producing, amyloid beta-specific CD4 T cells as targeted drug-delivery vehicles in Alzheimer's disease EBioMedicine https://www.ncbi.nlm.nih.gov/pubmed/31085101

Y. Elyahu, I. Hekselman, I. Eizenberg-Magar, O. Berner, I. Strominger, M. Schiller, K. Mittal, A. Nemirovsky, E. Eremenko, A. Vital, E. Simonovsky, V. Chalifa-Caspi, N. Friedman, E. Yeger-Lotem and A. Monsonego (2019) Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes Sci Adv https://www.ncbi.nlm.nih.gov/pubmed/31457092

B. Dagan, O. Oren, V. Banerjee, R. Taube and N. Papo (2019) A hyperthermophilic protein G variant engineered via directed evolution prevents the formation of toxic SOD1 oligomers Proteins https://www.ncbi.nlm.nih.gov/pubmed/31017342

T. Cooks, S. D. Theodorou, E. Paparouna, S. V. Rizou, V. Myrianthopoulos, V. G. Gorgoulis and I. S. Pateras (2019) Immunohisto(cyto)chemistry: an old time classic tool driving modern oncological therapies Histol Histopathol https://www.ncbi.nlm.nih.gov/pubmed/30480312

A. Cohen, S. Troib, S. Dotan, H. Najmuldeen, H. Yesilkaya, T. Kushnir, M. Shagan, M. Portnoi, H. Nachmani, R. Benisty, M. Tal, R. Ellis, V. Chalifa-Caspi, R. Dagan and Y. M. Nebenzahl (2019) Streptococcus pneumoniae Cell Wall-Localized Trigger Factor Elicits a Protective Immune Response and Contributes to Bacterial Adhesion to the Host Sci Rep https://www.ncbi.nlm.nih.gov/pubmed/30862841

M. Boichuck, J. Zorea, M. Elkabets, M. Wolfson and V. E. Fraifeld (2019) c-Met as a new marker of cellular senescence Aging (Albany NY) https://www.ncbi.nlm.nih.gov/pubmed/31085799

O. Beyar-Katz, K. Magidey, A. Reiner-Benaim, N. Barak, I. Avivi, Y. Cohen, M. Timaner, S. Avraham, M. Hayun, N. Lavi, M. Bersudsky, E. Voronov, R. N. Apte and Y. Shaked (2019) Proinflammatory Macrophages Promote Multiple Myeloma Resistance to Bortezomib Therapy Mol Cancer Res https://www.ncbi.nlm.nih.gov/pubmed/31409628

I. Ben-Aharon, M. Elkabets, R. Pelossof, K. H. Yu, C. A. Iacubuzio-Donahue, S. D. Leach, M. A. Lowery, K. A. Goodman and E. M. O'Reilly (2019) Genomic Landscape of Pancreatic Adenocarcinoma in Younger versus Older Patients: Does Age Matter? Clin Cancer Res https://www.ncbi.nlm.nih.gov/pubmed/30617137

I. Luz and T. Cooks (2019) Extracellular vesicles: what secrets do they hold inside? Cell Death Dis https://www.ncbi.nlm.nih.gov/pubmed/31138812

E. Barash, N. Sal-Man, S. Sabato and M. Ziv-Ukelson (2019) BacPaCS-Bacterial Pathogenicity Classification via Sparse-SVM Bioinformatics https://www.ncbi.nlm.nih.gov/pubmed/30407484

V. Banerjee, O. Oren, B. Dagan, R. Taube, S. Engel and N. Papo (2019) An Engineered Variant of the B1 Domain of Protein G Suppresses the Aggregation and Toxicity of Intra- and Extracellular Abeta42 ACS Chem Neurosci https://www.ncbi.nlm.nih.gov/pubmed/30428260

M. Badarni, M. Prasad, N. Balaban, J. Zorea, K. M. Yegodayev, B. Z. Joshua, A. B. Dinur, R. Grenman, B. Rotblat, L. Cohen and M. Elkabets (2019) Repression of AXL expression by AP-1/JNK blockage overcomes resistance to PI3Ka therapy JCI Insight https://www.ncbi.nlm.nih.gov/pubmed/30860495

M. H. Assadi, Y. Segev and A. Tarasiuk (2019) Irreversible metabolic abnormalities following chronic upper airway loading Sleep https://www.ncbi.nlm.nih.gov/pubmed/31353408

L. Aspit, A. Levitas, S. Etzion, H. Krymko, L. Slanovic, R. Zarivach, Y. Etzion and R. Parvari (2019) CAP2 mutation leads to impaired actin dynamics and associates with supraventricular tachycardia and dilated cardiomyopathy J Med Genet https://www.ncbi.nlm.nih.gov/pubmed/30518548

T. Almog, M. Kandel Kfir, H. Levkovich, G. Shlomai, I. Barshack, R. Stienstra, Y. Lustig, A. Leikin Frenkel, A. Harari, Y. Bujanover, R. Apte, A. Shaish, D. Harats and Y. Kamari (2019) Interleukin-1alpha deficiency reduces adiposity, glucose intolerance and hepatic de-novo lipogenesis in diet-induced obese mice BMJ Open Diabetes Res Care https://www.ncbi.nlm.nih.gov/pubmed/31749969

M. Abu-Halima, B. M. Ayesh, M. Hart, J. Alles, U. Fischer, M. Hammadeh, A. Keller, M. Huleihel and E. Meese (2019) Differential expression of miR-23a/b-3p and its target genes in male patients with subfertility Fertil Steril https://www.ncbi.nlm.nih.gov/pubmed/31056312

M. Abofoul-Azab, E. Lunenfeld, E. Levitas, A. Zeadna, J. S. Younis, S. Bar-Ami and M. Huleihel (2019) Identification of Premeiotic, Meiotic, and Postmeiotic Cells in Testicular Biopsies Without Sperm from Sertoli Cell-Only Syndrome Patients Int J Mol Sci https://www.ncbi.nlm.nih.gov/pubmed/30678285

E. Abaev-Schneiderman, L. Admoni-Elisha and D. Levy (2019) SETD3 is a positive regulator of DNA-damage-induced apoptosis Cell Death Dis https://www.ncbi.nlm.nih.gov/pubmed/30683849

Publications 2018

L. E. Weil, Y. Shmidov, M. Kublanovsky, D. Morgenstern, M. Feldman, R. Bitton and D. Levy (2018) Oligomerization and Auto-methylation of the Human Lysine Methyltransferase SETD6 J Mol Biol https://www.ncbi.nlm.nih.gov/pubmed/30189201

E. Voronov, C. A. Dinarello and R. N. Apte (2018) Interleukin-1alpha as an intracellular alarmin in cancer biology Semin Immunol https://www.ncbi.nlm.nih.gov/pubmed/30554608

H. Ventura-Bixenshpaner, H. Asraf, M. Chakraborty, M. Elkabets, I. Sekler, K. M. Taylor and M. Hershfinkel (2018) Enhanced ZnR/GPR39 Activity in Breast Cancer, an Alternative Trigger of Signaling Leading to Cell Growth Sci Rep https://www.ncbi.nlm.nih.gov/pubmed/29802348

I. Tseytin, A. Madar, B. Mitrovic, W. Deng, B. B. Finlay and N. Sal-Man (2018) The Third Transmembrane Domain of EscR Is Critical for Function of the Enteropathogenic Escherichia coli Type III Secretion System mSphere https://www.ncbi.nlm.nih.gov/pubmed/30045964

I. Tseytin, A. Dagan, S. Oren and N. Sal-Man (2018) The role of EscD in supporting EscC polymerization in the type III secretion system of enteropathogenic Escherichia coli Biochim Biophys Acta Biomembr https://www.ncbi.nlm.nih.gov/pubmed/28988128

M. Tiebe, M. Lutz, D. Levy and A. A. Teleman (2018) Phenotypic characterization of SETD3 knockout Drosophila PLoS One https://www.ncbi.nlm.nih.gov/pubmed/30067821

R. Tacutu, D. Thornton, E. Johnson, A. Budovsky, D. Barardo, T. Craig, E. Diana, G. Lehmann, D. Toren, J. Wang, V. E. Fraifeld and J. P. de Magalhaes (2018) Human Ageing Genomic Resources: new and updated databases Nucleic Acids Res https://www.ncbi.nlm.nih.gov/pubmed/29121237

I. Strominger, Y. Elyahu, O. Berner, J. Reckhow, K. Mittal, A. Nemirovsky and A. Monsonego (2018) The Choroid Plexus Functions as a Niche for T-Cell Stimulation Within the Central Nervous System Front Immunol https://www.ncbi.nlm.nih.gov/pubmed/29868025

A. Shemesh, K. Kundu, R. Peleg, R. Yossef, I. Kaplanov, S. Ghosh, Y. Khrapunsky, O. Gershoni-Yahalom, T. Rabinski, A. Cerwenka, R. Atlas and A. Porgador (2018) NKp44-Derived Peptide Binds Proliferating Cell Nuclear Antigen and Mediates Tumor Cell Death Front Immunol https://www.ncbi.nlm.nih.gov/pubmed/29875773

A. Shemesh, M. Brusilovsky, K. Kundu, A. Ottolenghi, K. S. Campbell and A. Porgador (2018) Splice variants of human natural cytotoxicity receptors: novel innate immune checkpoints Cancer Immunol Immunother https://www.ncbi.nlm.nih.gov/pubmed/29264698

O. Oren, V. Banerjee, R. Taube and N. Papo (2018) An Abeta42 variant that inhibits intra- and extracellular amyloid aggregation and enhances cell viability Biochem J https://www.ncbi.nlm.nih.gov/pubmed/30213841

A. C. Kaushik, A. Kumar, V. D. Dwivedi, S. Bharadwaj, S. Kumar, K. Bharti, P. Kumar, R. K. Chaudhary and S. K. Mishra (2018) Deciphering the Biochemical Pathway and Pharmacokinetic Study of Amyloid betaeta-42 with Superparamagnetic Iron Oxide Nanoparticles (SPIONs) Using Systems Biology Approach Mol Neurobiol https://www.ncbi.nlm.nih.gov/pubmed/28478508

R. Daudee, R. Gonen, U. German, I. Orion, Z. B. Alfassi and E. Priel (2018) DNA Topoisomerase IB as a Potential Ionizing Radiation Exposure and Dose Biomarker Radiat Res https://www.ncbi.nlm.nih.gov/pubmed/29633912

H. Naaman, T. Rabinski, A. Yizhak, S. Mizrahi, Y. S. Avni, R. Taube, B. Rager, Y. Weinstein, G. Rall, J. Gopas and R. Ofir (2018) Measles Virus Persistent Infection of Human Induced Pluripotent Stem Cells Cell Reprogram https://www.ncbi.nlm.nih.gov/pubmed/29412740

G. I. Morozov, N. Porat, T. Kushnir, H. Najmuldeen, A. Adawi, V. Chalifa-Caspi, R. Benisty, A. Ohayon, O. Liron, S. Azriel, I. Malka, S. Dotan, M. Portnoi, A. A. Piotrowski, D. Kafka, B. Hajaj, T. Fishilevich, M. Shagan, M. Tal, R. Ellis, D. A. Morrison, A. M. Mitchell, T. J. Mitchell, R. Dagan, H. Yesilkaya and Y. M. Nebenzahl (2018) Flavin Reductase Contributes to Pneumococcal Virulence by Protecting from Oxidative Stress and Mediating Adhesion and Elicits Protection Against Pneumococcal Challenge Sci Rep https://www.ncbi.nlm.nih.gov/pubmed/29321514

M. Abofoul-Azab, A. AbuMadighem, E. Lunenfeld, J. Kapelushnik, Q. Shi, H. Pinkas and M. Huleihel (2018) Development of Postmeiotic Cells In Vitro from Spermatogonial Cells of Prepubertal Cancer Patients Stem Cells Dev https://www.ncbi.nlm.nih.gov/pubmed/29779447

J. Zorea, M. Prasad, L. Cohen, N. Li, R. Schefzik, S. Ghosh, B. Rotblat, B. Brors and M. Elkabets (2018) IGF1R upregulation confers resistance to isoform-specific inhibitors of PI3K in PIK3CA-driven ovarian cancer Cell Death Dis https://www.ncbi.nlm.nih.gov/pubmed/30237504

M. Kublanovsky, A. Aharoni and D. Levy (2018) Enhanced PKMT-substrate recognition through non active-site interactions Biochem Biophys Res Commun https://www.ncbi.nlm.nih.gov/pubmed/29778536

D. Landau, L. London, I. Bandach and Y. Segev (2018) The hypoxia inducible factor/erythropoietin (EPO)/EPO receptor pathway is disturbed in a rat model of chronic kidney disease related anemia PLoS One https://www.ncbi.nlm.nih.gov/pubmed/29738538

D. H. Levy, A. Livny, H. Sgan-Cohen and N. Yavnai (2018) The association between caries related treatment needs and socio-demographic variables among young Israeli adults: a record based cross sectional study Isr J Health Policy Res https://www.ncbi.nlm.nih.gov/pubmed/29743092

S. Levy-Tzedek, G. S. Moran, U. Alon and N. Sal-Man (2018) Peer power: A women's peer-mentoring program at the workplace: example from the academia EMBO Rep https://www.ncbi.nlm.nih.gov/pubmed/30396884

A. Jabareen, M. Suleman, A. Abu-Jaafar and M. Huleihel (2018) Different molecular mechanisms of HTLV-1 and HIV LTR activation by TPA Biochem Biophys Res Commun https://www.ncbi.nlm.nih.gov/pubmed/29660338

N. Isakov (2018) Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression Semin Cancer Biol https://www.ncbi.nlm.nih.gov/pubmed/28571764

S. Gelkop, A. Sobarzo, P. Brangel, C. Vincke, E. Romao, S. Fedida-Metula, N. Strom, I. Ataliba, F. N. Mwiine, S. Ochwo, L. Velazquez-Salinas, R. A. McKendry, S. Muyldermans, J. J. Lutwama, E. Rieder, V. Yavelsky and L. Lobel (2018) The Development and Validation of a Novel Nanobody-Based Competitive ELISA for the Detection of Foot and Mouth Disease 3ABC Antibodies in Cattle Front Vet Sci https://www.ncbi.nlm.nih.gov/pubmed/30370272

M. Feldman and D. Levy (2018) Peptide inhibition of the SETD6 methyltransferase catalytic activity Oncotarget https://www.ncbi.nlm.nih.gov/pubmed/29435148

M. Elkabets and S. Brook (2018) Methods to Study the Role of Progranulin in the Tumor Microenvironment Methods Mol Biol https://www.ncbi.nlm.nih.gov/pubmed/29956276

B. Eilam-Frenkel, H. Naaman, G. Brkic, I. Veksler-Lublinsky, G. Rall, Y. Shemer-Avni and J. Gopas (2018) MicroRNA 146-5p, miR-let-7c-5p, miR-221 and miR-345-5p are differentially expressed in Respiratory Syncytial Virus (RSV) persistently infected HEp-2 cells Virus Res https://www.ncbi.nlm.nih.gov/pubmed/29733865

A. Edri, A. Shemesh, M. Iraqi, O. Matalon, M. Brusilovsky, U. Hadad, O. Radinsky, O. Gershoni-Yahalom, J. M. Dye, O. Mandelboim, M. Barda-Saad, L. Lobel and A. Porgador (2018) The Ebola-Glycoprotein Modulates the Function of Natural Killer Cells Front Immunol https://www.ncbi.nlm.nih.gov/pubmed/30013549

A. AbuMadighem, R. Solomon, A. Stepanovsky, J. Kapelushnik, Q. Shi, E. Meese, E. Lunenfeld and M. Huleihel (2018) Development of Spermatogenesis In Vitro in Three-Dimensional Culture from Spermatogonial Cells of Busulfan-Treated Immature Mice Int J Mol Sci https://www.ncbi.nlm.nih.gov/pubmed/30501072

K. Asraf, N. Torika, R. N. Apte and S. Fleisher-Berkovich (2018) Microglial Activation Is Modulated by Captopril: in Vitro and in Vivo Studies Front Cell Neurosci https://www.ncbi.nlm.nih.gov/pubmed/29765306

N. Bujanover, O. Goldstein, Y. Greenshpan, H. Turgeman, A. Klainberger, Y. Scharff and R. Gazit (2018) Identification of immune-activated hematopoietic stem cells Leukemia https://www.ncbi.nlm.nih.gov/pubmed/30042413

Y. J. Arnoldussen, V. Skaug, M. Aleksandersen, E. Ropstad, K. H. Anmarkrud, E. Einarsdottir, F. Chin-Lin, C. Granum Bjorklund, M. Kasem, E. Eilertsen, R. N. Apte and S. Zienolddiny (2018) Inflammation in the pleural cavity following injection of multi-walled carbon nanotubes is dependent on their characteristics and the presence of IL-1 genes Nanotoxicology https://www.ncbi.nlm.nih.gov/pubmed/29742950

H. Yanai and V. E. Fraifeld (2018) The role of cellular senescence in aging through the prism of Koch-like criteria Ageing Res Rev https://www.ncbi.nlm.nih.gov/pubmed/29106993

Publications 2017

M. Huleihel, M. Abofoul-Azab, Y. Abarbanel, I. Einav, E. Levitas and E. Lunenfeld (2017) Production of Macrophage Inhibitory Factor (MIF) by Primary Sertoli Cells; Its Possible Involvement in Migration of Spermatogonial Cells J Cell Physiol https://www.ncbi.nlm.nih.gov/pubmed/27925200

E. Toska, H. U. Osmanbeyoglu, P. Castel, C. Chan, R. C. Hendrickson, M. Elkabets, M. N. Dickler, M. Scaltriti, C. S. Leslie, S. A. Armstrong and J. Baselga (2017) PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D Science https://www.ncbi.nlm.nih.gov/pubmed/28336670

Y. Shemer-Avni, K. Kundu, A. Shemesh, M. Brusilovsky, R. Yossef, M. Meshesha, S. Solomon-Alemayehu, S. Levin, O. Gershoni-Yahalom, K. S. Campbell and A. Porgador (2017) Expression of NKp46 Splice Variants in Nasal Lavage Following Respiratory Viral Infection: Domain 1-Negative Isoforms Predominate and Manifest Higher Activity Front Immunol https://www.ncbi.nlm.nih.gov/pubmed/28261217

L. Shaulov, J. Gershberg, W. Deng, B. B. Finlay and N. Sal-Man (2017) The Ruler Protein EscP of the Enteropathogenic Escherichia coli Type III Secretion System Is Involved in Calcium Sensing and Secretion Hierarchy Regulation by Interacting with the Gatekeeper Protein SepL mBio https://www.ncbi.nlm.nih.gov/pubmed/28049143

O. Radinsky, A. Edri, M. Brusilovsky, S. Fedida-Metula, A. Sobarzo, O. Gershoni-Yahalom, J. Lutwama, J. Dye, L. Lobel and A. Porgador (2017) Sudan ebolavirus long recovered survivors produce GP-specific Abs that are of the IgG1 subclass and preferentially bind FcgammaRI Sci Rep https://www.ncbi.nlm.nih.gov/pubmed/28729706

O. Prager, A. Friedman and Y. M. Nebenzahl (2017) Role of neural barriers in the pathogenesis and outcome of Streptococcus pneumoniae meningitis Experimental and therapeutic medicine https://www.ncbi.nlm.nih.gov/pubmed/28450902

N. Nandakumar, S. Muthuraman, P. Gopinath, P. Nithya, J. Gopas and R. S. Kumar (2017) Synthesis of coumaperine derivatives: Their NF-kappaB inhibitory effect, inhibition of cell migration and their cytotoxic activity Eur J Med Chem https://www.ncbi.nlm.nih.gov/pubmed/27810594

T. Pazina, A. Shemesh, M. Brusilovsky, A. Porgador and K. S. Campbell (2017) Regulation of the Functions of Natural Cytotoxicity Receptors by Interactions with Diverse Ligands and Alterations in Splice Variant Expression Front Immunol https://www.ncbi.nlm.nih.gov/pubmed/28424697

J. Ozer, D. Fishman, B. Eilam, A. Golan-Goldhirsh and J. Gopas (2017) Anti-Metastatic Effect of Semi-Purified Nuphar Lutea Leaf Extracts J Cancer https://www.ncbi.nlm.nih.gov/pubmed/28638458

S. Nayak, W. Koven, I. Meiri, I. Khozin-Goldberg, N. Isakov, M. Zibdeh and D. Zilberg (2017) Dietary arachidonic acid affects immune function and fatty acid composition in cultured rabbitfish Siganus rivulatus Fish Shellfish Immunol https://www.ncbi.nlm.nih.gov/pubmed/28684322

I. Harpaz, U. Bhattacharya, Y. Elyahu, I. Strominger and A. Monsonego (2017) Old Mice Accumulate Activated Effector CD4 T Cells Refractory to Regulatory T Cell-Induced Immunosuppression Front Immunol https://www.ncbi.nlm.nih.gov/pubmed/28382033

N. Nandakumar, R. Dandela, J. Gopas and M. M. Meijler (2017) Quorum sensing modulators exhibit cytotoxicity in Hodgkin's lymphoma cells and interfere with NF-kappaB signaling Bioorg Med Chem Lett https://www.ncbi.nlm.nih.gov/pubmed/28526369

H. Naaman, G. Rall, C. Matullo, I. Veksler-Lublinsky, Y. Shemer-Avni and J. Gopas (2017) MiRNA-124 is a link between measles virus persistent infection and cell division of human neuroblastoma cells PLoS One https://www.ncbi.nlm.nih.gov/pubmed/29073265

C. Moskalev Acapital A, A. V. Kudryavtseva, A. S. Graphodatsky, V. R. Beklemisheva, N. A. Serdyukova, K. V. Krutovsky, V. V. Sharov, I. V. Kulakovskiy, A. S. Lando, A. S. Kasianov, D. A. Kuzmin, Y. A. Putintseva, S. I. Feranchuk, M. V. Shaposhnikov, V. E. Fraifeld, D. Toren, A. V. Snezhkina and V. V. Sitnik (2017) De novo assembling and primary analysis of genome and transcriptome of gray whale Eschrichtius robustus BMC Evol Biol https://www.ncbi.nlm.nih.gov/pubmed/29297306

L. Martin-Morales, M. Feldman, Z. Vershinin, P. Garre, T. Caldes and D. Levy (2017) SETD6 dominant negative mutation in familial colorectal cancer type X Hum Mol Genet https://www.ncbi.nlm.nih.gov/pubmed/28973356

A. Jabareen, A. Abu-Jaafar, A. Abou-Kandil and M. Huleihel (2017) Effect of TPA and HTLV-1 Tax on BRCA1 and ERE controlled genes expression Cell Cycle https://www.ncbi.nlm.nih.gov/pubmed/28594273

L. Jiang, T. Li, X. Zhang, B. Zhang, C. Yu, Y. Li, S. Fan, X. Jiang, T. Khan, Q. Hao, P. Xu, D. Nadano, M. Huleihel, E. Lunenfeld, P. J. Wang, Y. Zhang and Q. Shi (2017) RPL10L Is Required for Male Meiotic Division by Compensating for RPL10 during Meiotic Sex Chromosome Inactivation in Mice Curr Biol https://www.ncbi.nlm.nih.gov/pubmed/28502657

A. Kuzmina, S. Krasnopolsky and R. Taube (2017) Super elongation complex promotes early HIV transcription and its function is modulated by P-TEFb Transcription https://www.ncbi.nlm.nih.gov/pubmed/28340332

J. Kzhyshkowska, M. Bizzarri, R. Apte and N. Cherdyntseva (2017) Editorial: Targeting of Cancer Cells and Tumor Microenvironment: Perspectives for Personalized Therapy Curr Pharm Des https://www.ncbi.nlm.nih.gov/pubmed/29283049

R. N. Apte and E. Voronov (2017) Immunotherapeutic approaches of IL-1 neutralization in the tumor microenvironment J Leukoc Biol https://www.ncbi.nlm.nih.gov/pubmed/28522598

L. Huleihel, J. Sellares, N. Cardenes, D. Alvarez, R. Faner, K. Sakamoto, G. Yu, M. G. Kapetanaki, N. Kaminski and M. Rojas (2017) Modified mesenchymal stem cells using miRNA transduction alter lung injury in a bleomycin model Am J Physiol Lung Cell Mol Physiol https://www.ncbi.nlm.nih.gov/pubmed/28385811

T. Hickish, T. Andre, L. Wyrwicz, M. Saunders, T. Sarosiek, J. Kocsis, R. Nemecek, W. Rogowski, K. Lesniewski-Kmak, L. Petruzelka, R. N. Apte, P. Mohanty, M. Stecher, J. Simard and A. de Gramont (2017) MABp1 as a novel antibody treatment for advanced colorectal cancer: a randomised, double-blind, placebo-controlled, phase 3 study The Lancet. Oncology https://www.ncbi.nlm.nih.gov/pubmed/28094194

M. Golec, M. Wielscher, M. K. Lemieszek, K. Vierlinger, C. Skorska, S. Huetter, J. Sitkowska, B. Mackiewicz, A. Gora-Florek, R. Ziesche, H. Yanai, V. E. Fraifeld, J. Milanowski and J. Dutkiewicz (2017) Middle age enhances expression of innate immunity genes in a female mouse model of pulmonary fibrosis Biogerontology https://www.ncbi.nlm.nih.gov/pubmed/28093691

O. Goldstein, K. Meyer, Y. Greenshpan, N. Bujanover, M. Feigin, H. Ner-Gaon, T. Shay and R. Gazit (2017) Mapping Whole-Transcriptome Splicing in Mouse Hematopoietic Stem Cells Stem Cell Reports https://www.ncbi.nlm.nih.gov/pubmed/28041879

N. Gobshtis, M. Tfilin, M. Wolfson, V. E. Fraifeld and G. Turgeman (2017) Transplantation of mesenchymal stem cells reverses behavioural deficits and impaired neurogenesis caused by prenatal exposure to valproic acid Oncotarget https://www.ncbi.nlm.nih.gov/pubmed/28407680

A. Fiore-Gartland, A. Panoskaltsis-Mortari, A. A. Agan, A. J. Mistry, P. G. Thomas, M. A. Matthay, P. P. Investigators, T. Hertz and A. G. Randolph (2017) Cytokine Profiles of Severe Influenza Virus-Related Complications in Children Front Immunol https://www.ncbi.nlm.nih.gov/pubmed/29163498

N. Fallik, Y. Bar-Lavan, Y. Greenshpan, O. Goldstein, M. Grosch, M. Drukker and R. Gazit (2017) Neat1 in hematopoietic stem cells Oncotarget https://www.ncbi.nlm.nih.gov/pubmed/29312630

V. Eisenberg, K. Shamalov, S. Meir, S. Hoogi, R. Sarkar, S. Pinker, G. Markel, A. Porgador and C. J. Cohen (2017) Targeting Multiple Tumors Using T-Cells Engineered to Express a Natural Cytotoxicity Receptor 2-Based Chimeric Receptor Front Immunol https://www.ncbi.nlm.nih.gov/pubmed/29085357

S. Bhattacharya, R. Sarkar, S. Nandi, A. Porgador and R. Jelinek (2017) Detection of Reactive Oxygen Species by a Carbon-Dot-Ascorbic Acid Hydrogel Anal Chem https://www.ncbi.nlm.nih.gov/pubmed/27991760

G. Dong, R. Kalifa, P. R. Nath, S. Gelkop and N. Isakov (2017) TCR crosslinking promotes Crk adaptor protein binding to tyrosine-phosphorylated CD3zeta chain Biochem Biophys Res Commun https://www.ncbi.nlm.nih.gov/pubmed/28526413

G. Dong, R. Kalifa, P. R. Nath, Y. Babichev, S. Gelkop and N. Isakov (2017) Crk adaptor proteins regulate CD3zeta chain phosphorylation and TCR/CD3 down-modulation in activated T cells Cell Signal https://www.ncbi.nlm.nih.gov/pubmed/28465009

P. Dash, A. J. Fiore-Gartland, T. Hertz, G. C. Wang, S. Sharma, A. Souquette, J. C. Crawford, E. B. Clemens, T. H. O. Nguyen, K. Kedzierska, N. L. La Gruta, P. Bradley and P. G. Thomas (2017) Quantifiable predictive features define epitope-specific T cell receptor repertoires Nature https://www.ncbi.nlm.nih.gov/pubmed/28636592

P. Rider, E. Voronov, C. A. Dinarello, R. N. Apte and I. Cohen (2017) Alarmins: Feel the Stress J Immunol https://www.ncbi.nlm.nih.gov/pubmed/28167650

S. Bhattacharya, R. Sarkar, B. Chakraborty, A. Porgador and R. Jelinek (2017) Nitric Oxide Sensing through Azo-Dye Formation on Carbon Dots ACS Sens https://www.ncbi.nlm.nih.gov/pubmed/28770991

M. Arafat, I. Har-Vardi, A. Harlev, E. Levitas, A. Zeadna, M. Abofoul-Azab, V. Dyomin, V. C. Sheffield, E. Lunenfeld, M. Huleihel and R. Parvari (2017) Mutation in TDRD9 causes non-obstructive azoospermia in infertile men J Med Genet https://www.ncbi.nlm.nih.gov/pubmed/28536242

A. Balan, I. Szaingurten-Solodkin, S. S. Swissa, V. Feinshtein, M. Huleihel, G. Holcberg, D. Dukler and O. Beharier (2017) The effects of pravastatin on the normal human placenta: Lessons from ex-vivo models PLoS One https://www.ncbi.nlm.nih.gov/pubmed/28199380

V. Banerjee, O. Oren, E. Ben-Zeev, R. Taube, S. Engel and N. Papo (2017) A computational combinatorial approach identifies a protein inhibitor of superoxide dismutase 1 misfolding, aggregation, and cytotoxicity J Biol Chem https://www.ncbi.nlm.nih.gov/pubmed/28768772

D. Barardo, D. Thornton, H. Thoppil, M. Walsh, S. Sharifi, S. Ferreira, A. Anzic, M. Fernandes, P. Monteiro, T. Grum, R. Cordeiro, E. A. De-Souza, A. Budovsky, N. Araujo, J. Gruber, M. Petrascheck, V. E. Fraifeld, A. Zhavoronkov, A. Moskalev and J. P. de Magalhaes (2017) The DrugAge database of aging-related drugs Aging cell https://www.ncbi.nlm.nih.gov/pubmed/28299908

S. Yehuda, H. Yanai, E. Priel and V. E. Fraifeld (2017) Differential decrease in soluble and DNA-bound telomerase in senescent human fibroblasts Biogerontology https://www.ncbi.nlm.nih.gov/pubmed/28251405

H. Yanai, A. Budovsky, T. Barzilay, R. Tacutu and V. E. Fraifeld (2017) Wide-scale comparative analysis of longevity genes and interventions Aging cell https://www.ncbi.nlm.nih.gov/pubmed/28836369

E. Voronov and R. N. Apte (2017) Targeting the Tumor Microenvironment by Intervention in Interleukin-1 Biology Curr Pharm Des https://www.ncbi.nlm.nih.gov/pubmed/28606052P

Publications 2016

O. Reish, L. Aspit, A. Zouella, Y. Roth, S. Polak-Charcon, T. Baboushkin, L. Benyamini, T. E. Scheetz, H. Mussaffi, V. C. Sheffield and R. Parvari (2016) A Homozygous Nme7 Mutation Is Associated with Situs Inversus Totalis Hum Mutat https://www.ncbi.nlm.nih.gov/pubmed/27060491

M. Scaltriti, M. Elkabets and J. Baselga (2016) Molecular Pathways: AXL, a Membrane Receptor Mediator of Resistance to Therapy Clin Cancer Res https://www.ncbi.nlm.nih.gov/pubmed/26763248

Y. Shamay, M. Elkabets, H. Li, J. Shah, S. Brook, F. Wang, K. Adler, E. Baut, M. Scaltriti, P. V. Jena, E. E. Gardner, J. T. Poirier, C. M. Rudin, J. Baselga, A. Haimovitz-Friedman and D. A. Heller (2016) P-selectin is a nanotherapeutic delivery target in the tumor microenvironment Sci Transl Med https://www.ncbi.nlm.nih.gov/pubmed/27358497

A. Shemesh, M. Brusilovsky, U. Hadad, O. Teltsh, A. Edri, E. Rubin, K. S. Campbell, B. Rosental and A. Porgador (2016) Survival in acute myeloid leukemia is associated with NKp44 splice variants Oncotarget https://www.ncbi.nlm.nih.gov/pubmed/27102296

A. Shemesh, A. Kugel, N. Steiner, M. Yezersky, D. Tirosh, A. Edri, O. Teltsh, B. Rosental, E. Sheiner, E. Rubin, K. S. Campbell and A. Porgador (2016) NKp44 and NKp30 splice variant profiles in decidua and tumor tissues: a comparative viewpoint Oncotarget https://www.ncbi.nlm.nih.gov/pubmed/27765926

D. Toren, T. Barzilay, R. Tacutu, G. Lehmann, K. K. Muradian and V. E. Fraifeld (2016) MitoAge: a database for comparative analysis of mitochondrial DNA, with a special focus on animal longevity Nucleic Acids Res https://www.ncbi.nlm.nih.gov/pubmed/26590258

Z. Vershinin, M. Feldman, A. Chen and D. Levy (2016) PAK4 Methylation by SETD6 Promotes the Activation of the Wnt/beta-Catenin Pathway J Biol Chem https://www.ncbi.nlm.nih.gov/pubmed/26841865

H. Yanai, A. Budovsky, R. Tacutu, T. Barzilay, A. Abramovich, R. Ziesche and V. E. Fraifeld (2016) Tissue repair genes: the TiRe database and its implication for skin wound healing Oncotarget https://www.ncbi.nlm.nih.gov/pubmed/27049721

H. Yanai, D. B. Lumenta, K. Vierlinger, M. Hofner, H. B. Kitzinger, L. P. Kamolz, C. Nohammer, M. Chilosi and V. E. Fraifeld (2016) Middle age has a significant impact on gene expression during skin wound healing in male mice Biogerontology https://www.ncbi.nlm.nih.gov/pubmed/27241672

H. Yanai, D. Toren, K. Vierlinger, M. Hofner, C. Nohammer, M. Chilosi, A. Budovsky and V. E. Fraifeld (2016) Erratum: Wound healing and longevity: Lessons from long-lived alphaMUPA mice Aging (Albany NY) https://www.ncbi.nlm.nih.gov/pubmed/27075514

Y. Mizrachi Nebenzahl, K. Blau, T. Kushnir, M. Shagan, M. Portnoi, A. Cohen, S. Azriel, I. Malka, A. Adawi, D. Kafka, S. Dotan, G. Guterman, S. Troib, T. Fishilevich, J. M. Gershoni, A. Braiman, A. M. Mitchell, T. J. Mitchell, N. Porat, I. Goliand, V. Chalifa Caspi, E. Swiatlo, M. Tal, R. Ellis, N. Elia and R. Dagan (2016) Streptococcus pneumoniae Cell-Wall-Localized Phosphoenolpyruvate Protein Phosphotransferase Can Function as an Adhesin: Identification of Its Host Target Molecules and Evaluation of Its Potential as a Vaccine PLoS One https://www.ncbi.nlm.nih.gov/pubmed/26990554

P. R. Nath, G. Dong, A. Braiman and N. Isakov (2016) In vivo regulation of human CrkII by cyclophilin A and FK506-binding protein Biochem Biophys Res Commun https://www.ncbi.nlm.nih.gov/pubmed/26792730

S. Orr, I. Strominger, E. Eremenko, E. Vinogradov, E. Ruvinov, A. Monsonego and S. Cohen (2016) TGF-beta affinity-bound to a macroporous alginate scaffold generates local and peripheral immunotolerant responses and improves allocell transplantation Acta Biomater https://www.ncbi.nlm.nih.gov/pubmed/27523029

M. K. Meshesha, Z. Bentwich, S. A. Solomon and Y. S. Avni (2016) In vivo expression of human cytomegalovirus (HCMV) microRNAs during latency Gene https://www.ncbi.nlm.nih.gov/pubmed/26302752

K. I. Andreasson, A. D. Bachstetter, M. Colonna, F. Ginhoux, C. Holmes, B. Lamb, G. Landreth, D. C. Lee, D. Low, M. A. Lynch, A. Monsonego, M. K. O'Banion, M. Pekny, T. Puschmann, N. Russek-Blum, L. A. Sandusky, M. L. Selenica, K. Takata, J. Teeling, T. Town and L. J. Van Eldik (2016) Targeting innate immunity for neurodegenerative disorders of the central nervous system J Neurochem https://www.ncbi.nlm.nih.gov/pubmed/27248001

J. Gopas, E. Stern, U. Zurgil, J. Ozer, A. Ben-Ari, G. Shubinsky, A. Braiman, R. Sinay, J. Ezratty, V. Dronov, S. Balachandran, D. Benharroch and E. Livneh (2016) Reed-Sternberg cells in Hodgkin's lymphoma present features of cellular senescence Cell Death Dis https://www.ncbi.nlm.nih.gov/pubmed/27831553

Y. J. Arnoldussen, K. H. Anmarkrud, V. Skaug, R. N. Apte, A. Haugen and S. Zienolddiny (2016) Effects of carbon nanotubes on intercellular communication and involvement of IL-1 genes J Cell Commun Signal https://www.ncbi.nlm.nih.gov/pubmed/27101311

A. Chen, M. Feldman, Z. Vershinin and D. Levy (2016) SETD6 is a negative regulator of oxidative stress response Biochim Biophys Acta https://www.ncbi.nlm.nih.gov/pubmed/26780326

D. O. Cohen, S. Duchin, M. Feldman, R. Zarivach, A. Aharoni and D. Levy (2016) Engineering of Methylation State Specific 3xMBT Domain Using ELISA Screening PLoS One https://www.ncbi.nlm.nih.gov/pubmed/27111853

O. Cohn, A. Chen, M. Feldman and D. Levy (2016) Proteomic analysis of SETD6 interacting proteins Data in brief https://www.ncbi.nlm.nih.gov/pubmed/26937450

O. Cohn, M. Feldman, L. Weil, M. Kublanovsky and D. Levy (2016) Chromatin associated SETD3 negatively regulates VEGF expression Sci Rep https://www.ncbi.nlm.nih.gov/pubmed/27845446

E. Eitan, C. Braverman, A. Tichon, D. Gitler, E. R. Hutchison, M. P. Mattson and E. Priel (2016) Excitotoxic and Radiation Stress Increase TERT Levels in the Mitochondria and Cytosol of Cerebellar Purkinje Neurons Cerebellum https://www.ncbi.nlm.nih.gov/pubmed/26374457

E. Eitan, A. Tamar, G. Yossi, R. Peleg, A. Braiman and E. Priel (2016) Expression of functional alternative telomerase RNA component gene in mouse brain and in motor neurons cells protects from oxidative stress Oncotarget https://www.ncbi.nlm.nih.gov/pubmed/27823970

S. Elhaik Goldman, S. Dotan, A. Talias, A. Lilo, S. Azriel, I. Malka, M. Portnoi, A. Ohayon, D. Kafka, R. Ellis, M. Elkabets, A. Porgador, D. Levin, R. Azhari, E. Swiatlo, E. Ling, G. Feldman, M. Tal, R. Dagan and Y. Mizrachi Nebenzahl (2016) Streptococcus pneumoniae fructose-1,6-bisphosphate aldolase, a protein vaccine candidate, elicits Th1/Th2/Th17-type cytokine responses in mice Int J Mol Med https://www.ncbi.nlm.nih.gov/pubmed/26935978

S. Elhaik Goldman, I. Moshkovits, A. Shemesh, A. Filiba, Y. Tsirulsky, E. Vronov, M. Shagan, R. N. Apte, D. A. Benharroch, D. Karo-Atar, R. Dagan, A. Munitz, Y. Mizrachi Nebenzahl and A. Porgador (2016) Natural Killer Receptor 1 Dampens the Development of Allergic Eosinophilic Airway Inflammation PLoS One https://www.ncbi.nlm.nih.gov/pubmed/27580126

A. Fiore-Gartland, B. A. Manso, D. P. Friedrich, E. E. Gabriel, G. Finak, Z. Moodie, T. Hertz, S. C. De Rosa, N. Frahm, P. B. Gilbert and M. J. McElrath (2016) Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials PLoS One https://www.ncbi.nlm.nih.gov/pubmed/26863315

E. A. Karlsson, T. Hertz, C. Johnson, A. Mehle, F. Krammer and S. Schultz-Cherry (2016) Obesity Outweighs Protection Conferred by Adjuvanted Influenza Vaccination mBio https://www.ncbi.nlm.nih.gov/pubmed/27486196

A. Abou-Kandil, N. Eisa, A. Jabareen and M. Huleihel (2016) Differential effects of HTLV-1 Tax oncoprotein on the different estrogen-induced-ER alpha-mediated transcriptional activities Cell Cycle https://www.ncbi.nlm.nih.gov/pubmed/27420286