Michal Hershfinkel - The Zinc Biology Lab

M. Chakraborty, H. Asraf, I. Sekler, M. Hershfinkel. ZnR/GPR39 controls cell migration by orchestrating recruitment of KCC3 into protrusions, re-organization of actin and activation of MMP. Cell Calcium, 202; 94: 102330.
RF Krall, A Moutal, MB Phillips, H Asraf, JW Johnson, R Khanna, M. Hershfinkel, E. Aizenman, T.Tzounopoulos. Synaptic zinc inhibition of NMDA receptors depends on the association of GluN2A with the zinc transporter ZnT1. Sci Adv. 2020; 6(27):eabb1515.
E. Hoch, M Levy, M. Hershfinkel, I. Sekler. Elucidating the H+ Coupled Zn²⁺ Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica.Int J Mol Sci. 2020; 21(3):734.
M. Mero, H. Asraf, I. Sekler, KM Taylor, M. Hershfinkel. ZnR/GPR39 upregulation of K+/Cl--cotransporter 3 in tamoxifen resistant breast cancer cells. Cell Calcium. 2019; 81:12-20.
M. Hershfinkel^*, J. Iv, S.L. Kelleher: Zinc Signaling (Zinc'ing) in Intestinal Function. In: “Zinc Signaling". Fukada T., Kambe T. (eds) Springer Singapore (2019).
M. Levy, N. Elkoshi, S. Barber-Zucker, E. Hoch, R. Zarivach, M. Hershfinkel, I. Sekler. Zinc transporter 10 (ZnT10)-dependent extrusion of cellular Mn²⁺ is driven by an active Ca²⁺-coupled exchange. J Biol Chem. 2019;294(15):5879-5889.
H. Ventura-Bixenshpaner, Asraf H, Chakraborty M, Elkabets M, Sekler I, Taylor KM, M. Hershfinkel: Enhanced ZnR/GPR39 Activity in Breast Cancer, an Alternative Trigger of Signaling Leading to Cell Growth. Sci Rep. 2018;8(1):8119.
N. Levaot, M.Hershfinkel : How cellular Zn²⁺ signaling drives physiological functions. Cell Calcium. 2018;75:53-63.
M. Hershfinkel: The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease. Int J Mol Sci. 2018 Feb 1;19(2). pii: E439.
L. Sunuwar, H. Asraf, M. Donowitz, I. Sekler and M. Hershfinkel : The Zn²⁺-sensing receptor, ZnR/GPR39, upregulates colonocytic Cl- absorption, via basolateral KCC1, and reduces fluid loss. Biochim Biophys Acta. 2017; 1863(4):947-960.
L. Sunuwar, D. Gilad, M. Hershfinkel: The zinc sensing receptor, ZnR/GPR39, in health and disease. Front Biosci (Landmark Ed). 2017;22:1469-1492.
C. Abramovitch-Dahan, H. Asraf, M. Bogdanovic, I. Sekler, AI Bush and M. Hershfinkel: Amyloid β attenuates metabotropic zinc sensing receptor, mZnR/GPR39, dependent Ca²⁺, ERK1/2 and Clusterin signaling in neurons. J Neurochem. 2016; 139(2):221-233.
L. Sunuwar, M. Medini, L. Cohen, I. Sekler and M. Hershfinkel: The zinc sensing receptor, ZnR/GPR39, triggers metabotropic calcium signalling in colonocytes and regulates occludin recovery in experimental colitis. Philos Trans R Soc Lond B Biol Sci. 2016;371(1700).
T. Ganay, H. Asraf, M. Bogdanovic, I. Sekler, E. Aizenman and M. Hershfinkel: Regulation of Neuronal pH by the Metabotropic Zinc Receptor mZnR/GPR39. (2015) J. NeuroChem., 135(5):897-907.
M. Hershfinkel, D. Ford, S.L. Kelleher, E. Aizenman, Seashells by the zinc shore: a meeting report of the International Society for Zinc Biology, Asilomar, CA 2014. Metallomics. (2015) ;7(9):1299-304.
D. Gilad, S. Shorer, M. Ketzef, A. Friedman, I. Sekler, E. Aizenman and M. Hershfinkel: Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures. (2015)
Neurobiol Dis., 81:4-13.
H. Asraf, Avunie-Masala R, M. Hershfinkel, Gheber L.: Mitotic slippage and expression of survivin are linked to differential sensitivity of human cancer cell-lines to the Kinesin-5 inhibitor monastrol. (2015) PLoS One, 10(6):e0129255.
L. Yassin, S. Radtke-Schuller, H. Asraf, B. Grothe, M. Hershfinkel, I. D Forsythe, C. Kopp-Scheinpflug: Nitric oxide signalling modulates synaptic inhibition in the superior paraolivary nucleus (SPN) via cGMP-dependent suppression of KCC2. (2014) Frontiers in Neural Circuits, 8:65.
L. Cohen, I. Sekler, M. Hershfinkel: The zinc sensing receptor, ZnR/GPR39, controls proliferation and differentiation of colonocytes and thereby tight junction formation in the colon. (2014) Cell Death & Disease, Jun 26;5:e1307.
H. Asraf, S. Salomon, A. Nevo, I. Sekler, D. Mayer, M. Hershfinkel: The ZnR/GPR39 Interacts with the CaSR to Enhance Signaling in Prostate and Salivary Epithelia (2013) J Cell Physiol., 229(7):868-77.
S. Grebhardt, K. Müller-Decker, F. Bestvater, M. Hershfinkel, D. Mayer: Impact of S100A8/A9 expression on prostate cancer progression in vitro and in vivo. (2013) J Cell Physiol. 229(5):661-71.
T. Perez-Rosello, CT Anderson, FJ Schopfer, Y. Zhao, D. Gilad, SR Salvatore, BA Freeman, M. Hershfinkel, E. Aizenman, T. Tzounopoulos: Synaptic Zn²⁺ inhibits neurotransmitter release by promoting endocannabinoid synthesis. (2013) J Neurosci. 33(22):9259-72.
IL Nita, M. Hershfinkel, D Fishman, E Ozeri, GA Rutter, SL Sensi, D Khananshvili, EC Lewis, I Sekler: The mitochondrial Na(+)/Ca(²⁺) exchanger upregulates glucose dependent Ca(²⁺) signalling linked to insulin secretion (2012) PLoS One 7(10):e46649.
L Cohen, H Asraf, I Sekler I, M. Hershfinkel: Extracellular pH Regulates Zinc Signaling via an Asp Residue of the Zinc-Sensing Receptor (ZnR/GPR39) (2012) J Biol Chem. 287:33339-50.
L Cohen, H Azriel-Tamir, N Arotsker, I Sekler, M. Hershfinkel :Zinc sensing receptor signaling, mediated by GPR39, reduces butyrate-induced cell death in HT29 colonocytes via upregulation of clusterin (2012) PLoS One. 7(4):e35482
E Hoch, W Lin, J Chai, M. Hershfinkel, D Fu, I Sekler :Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn²⁺ over Cd²⁺ selectivity (2012) Proc Natl Acad Sci U S A. 109(19):7202-7.
RA Saadi, K He, KA Hartnett, K Kandler, M. Hershfinkel, E. Aizenman: SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro (2012) Neuroscience 210:38-46.
SL Sensi, P Paoletti, JY Koh, E Aizenman, AI Bush, M.Hershfinkel: The neurophysiology and pathology of brain zinc. J Neurosci. 2011 Nov 9;31(45):16076-85.
E. Chorin, O. Vinograd, I. Fleidervish, D. Gilad, S. Herrmann, I. Sekler, E. Aizenman, M. Hershfinkel: Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor (2011), J. Neurosci. 31(36):12916-26.
M. Hershfinkel, E. Aizenman, G. Andrews, I. Sekler, "Zinc bells rang in Jerusalem!", Sci Signal. 2010, 3, 129:mr2.
H. Sharir, A. Zinger, A. Nevo, I. Sekler, M. Hershfinkel: Zinc released from injured cells is acting via the Zn²⁺-sensing receptor, ZnR, to trigger signaling leading to epithelial repair (2010), J. Biol. Chem. 285, 26097-106.
N. Karol, C. Brodski, Y. Bibi, T. Kaisman, M. Forberg, M. Hershfinkel, I. Sekler, WF Silverman: Zinc homeostatic proteins in the CNS are regulated by crosstalk between extracellular and intracellular zinc (2010), J Cell Physiol. 224, 567-74.
R. Palty, WF. Silverman, M. Hershfinkel, T. Caporale, SL. Sensi, J. Parnis, C. Nolte, D. Fishman, V. Shoshan-Barmatz, S. Herrmann, D. Khananshvili, I. Sekler: NCLX is an essential component of mitochondrial Na+/Ca²⁺ exchange (2010), PNAS, 107, 436-441.
M. Hershfinkel, K. Kandler, M. E. Knoch, K. A. Hartnett, M. Dagan-Rabin, I. Sekler and E. Aizenman: Intracellular Zinc Inhibits KCC2 Transporter Function (2009), Nature Neuroscience, 12, 725-7.
L. Besser, E. Chorin, I. Sekler, W. F. Silverman, S. Atkin, J. T. Russell and M. Hershfinkel: Synaptically-Released Zinc Triggers Metabotropic Signaling via a Zinc Sensing Receptor in the Hippocampus (2009), J. Neuroscience, 29, 2890-901.
E. Ohana, E. Hoch, C. Keisar, T. Kambe, O. Yifrach, M. Hershfinkel, I. Sekler: Identification of the Zn²⁺ binding site and mode of operation of a mammalian Zn²⁺ transporter (2009), J Biol Chem., 284, 17677-17686.
T. Kaisman-Elbaz, I. Sekler, D. Fishman, N. Karol, M. Forberg, N. Kahn, M. Hershfinkel, W.F. Silverman: Cell death induced by zinc and cadmium is mediated by clusterin in cultured mouse seminiferous tubules (2009), J Cell Physiol., 220, 222-9 .
N. Dubi, L. Gheber, D. Fishman, I. Sekler and M. Hershfinkel: Extracellular zinc and zinc-citrate, acting through a putative zinc sensing receptor, regulate growth and survival of prostate cancer cells (2008), Carcinogenesis, 9, 1692-700.
M. Hershfinkel^#, WF. Silverman and I. Sekler: The Zinc Sensing Receptor, a link between Zinc and Cell Signaling (2007), Mol. Med., 13, 331-6.
T. Priel and M. Hershfinkel: Zinc influx and physiological consequences in the b- insulinoma cell line, Min6, (2006), Biochem Biophys Res Commun., 346, 205-12.
E. Ohana, I. Sekler T. Kaisman, N. Kahn, J. Cove, WF. Silverman, A. Amsterdam, and M. Hershfinkel: Silencing of ZnT-1 expression enhances heavy metal influx and toxicity, (2006), J. Mol. Med., 84, 753-63 .
CJ. Frederickson, LJ. Giblin III, B. Rengarajan, R. Masalha, CJ. Frederickson, Y. Zeng, E. Varea Lopez, JY. Koh, U. Chorin, L. Besser, M. Hershfinkel, Y. Li, RB. Thompson and A. Krężel: Synaptic release of zinc from brain slices: Factors governing release, imaging, and accurate calculation of concentration, (2006), J. Neuorosci. Methods. 154, 19-29.
H. Sharir and M. Hershfinkel: The extracellular zinc-sensing receptor mediates intercellular communication by inducing ATP release, (2005), Biochem Biophys Res Commun. 332, 845-52.
H. Azriel-Tamir, H. Sharir, B. Schwartz and M. Hershfinkel: Extracellular zinc triggers ERK-dependent activation of Na⁺/H⁺ exchange in colonocytes mediated by the zinc sensing receptor, (2004), J. Biol. Chem., 279, 51804-16.
R. Palty, E. Ohana, M. Hershfinkel, M. Volokita, V. Elgazar, O. Beharier, W.F. Silverman, M. Argaman, I. Sekler: Lithium-Calcium Exchange Is Mediated By A Distinct Potassium-Independent Sodium-Calcium Exchanger, (2004), J. Biol. Chem., 279, 25234-40.
V. Elgazar, V. Razanov, M. Stoltenberg, M. Hershfinkel, M. Huleihel, Y. Nitzan, E. Lunenfeld, I. Sekler and W.F. Silverman: Zinc-Regulating Proteins, ZnT-1 and metallothionein I/II are Present in Different Cell Populations in the Mouse Testis. (2004), J. Histochem. Cytochem, 53, 905-12.
I. Sekler, A. Moran, M. Hershfinkel, N. Birenzwig and W.F. Silverman: Distribution of the zinc transporter ZnT-1 in the mouse brain, (2002), JCN, 447, 201–209.
Y.B. Nitzan, I. Sekler, M. Hershfinkel, A. Moran, A. Dori and W. F. Silverman: Postnatal regulation of ZnT-1 expression in the mouse brain, (2002), Develop. Brain Res. 137, 149–157
M. Hershfinkel, A. Moran, N. Grossman and I. Sekler: A Novel Zinc-Sensing Receptor Triggers the Release of Intracellular Ca²⁺ and Regulates Ion Transport, (2001), PNAS, 98 ,11749-11754.
L.A. Gheber, M. Hershfinkel, G. Gorodetsky and V. Volterra: Investigation of the Composition and Electrical Properties of Gold-H-terminated Silicon(111) Interface, (1998), Thin Solid Films, 320, 228-235.
M. Hershfinkel, L.A. Gheber, M. Homyonfer, R. Tenne and V. Volterra: Surface Modifications: Nano-Structures and Nested Polyhedra Generated by Pulsing the STM Tip, (1997), Surf. Rev. and Lett. 4, 1015-1020.
M. Hershfinkel, L.A. Gheber, V. Volterra, J.L. Hutchison, L. Margulis, R Tenne: Nested polyhedra of MX2 (M=W, Mo; X=S, Se) probed by High-Resolution Electron Microscopy and Scanning Tunneling Microscopy, (1994), J. Amer. Chem. Soc., 116, 1914-1917.

Publications