Dr. Toiber is currently establishing her lab at the department of Life Science. Her study is focusing on the role of SIRT6 in chromatin organization of the brain and its involvement in neurodegeneration disease. Cells deficient in SIRT6 exhibit genomic instability, sensitivity to genotoxic damage and defects in DNA repair. Moreover, SIRT6 seems to be preventing genomic instability, specifically in the brain that can cause behavioral defects in mouse model. Her study includes analysis of gene expression changes in SIRT6 KO compared to WT mice using RNA-seq; analysis of SIRT6 targets genes in WT mice by ChIP-seq; and testing the DNA damage in SIRT6 KO mouse brains using ChIP-seq with γH2AX, a marker of DNA damage.