Book Chapters
M. Popov, A. Goldstein-Levitin and L. Gheber. (2020) The Kinesin-5 Family, Transporters and Creators. In the Kinesin Superfamily Handbook. Boca Raton: CRC Press, Friel, C. (Ed.). https://www.taylorfrancis.com/books/edit/10.1201/9780429491559/kinesin-superfamily-handbook-claire-friel
L. Gheber and Z. Priel. (1998) Metachronal wave, ciliary stroke and mucus propulsion. In Mucus Cilia and Mucociliary Interactions, Marcel Dekker, Inc. Edited by G.L. Baum et al., pp. 103-118.
Refereed articles in scientific journals
A. Goldstein-Levitin, H. Pandey, K. Allhuzaeel, Itamar Kassc, L. Gheber (2021) Intracellular functions and motile properties of bi-directional kinesin-5 Cin8 are regulated by neck linker docking eLife. 2021 Aug 13 https://elifesciences.org/articles/71036
H. Pandey, M. Popov, A. Goldstein-Levitin, L. Gheber (2021) Mechanisms by which Kinesin-5 motors perform their multiple intracellular functions. International Journal of Molecular Sciences. Jun 15;22(12):6420 https://www.mdpi.com/1422-0067/22/12/6420
H. Pandey, S.K. Singh, M. Sadan, M. Popov, M. Singh, G. Davidov, S. Inagaki, J.A. Bassam, R. Zarivach, S.S. Rosenfeld, L. Gheber (2021) Flexible microtubule anchoring modulates the bi-directional motility of the kinesin-5 Cin8. Cellular and Molecular Life Sciences. Aug;78(16):6051-6068 https://link.springer.com/article/10.1007/s00018-021-03891-x
H. Pandey, E. Reithmann, Alina Goldstein-Levitin, J. Al-Bassam, E. Frey, L. Gheber (2021) Drag-induced directionality switching of kinesin-5 Cin8 revealed by cluster-motility analysis. Science Advances 7(6) eabc1687 https://www.science.org/doi/10.1126/sciadv.abc1687?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&
T. Bodrug, E. Wilson-Kubalek, S. Nithianantham, A.F. Thompson, A. Alfieri, I. Gaska, J. Major, G. Debs, S. Inagaki, P. Gutierrez, L. Gheber, R. McKenney, C. Sindelar, R. Milligan, J. Stumpff, S. Rosenfeld, S.T. Forth, J. Al-Bassam (2020) The Kinesin-5 Tail Domain Directly Modulates the Mechanochemical Cycle of the Motor for Anti-Parallel Microtubule Sliding. eLife Jan 20;9:e51131 https://elifesciences.org/articles/51131
A. Goldstein, D. Goldman, E. Valk, M. Loog, L.J. Holt and L. Gheber (2019) Synthetic-evolution reveals narrow paths to regulation of the saccharomyces cerevisiae mitotic kinesin-5 Cin8. International Journal of Biological Sciences 15(6):1125-1138 https://www.ijbs.com/v15p1125.htm
S.K. Singh, H. Pandey, J. Al-Bassam, and L. Gheber (2018) Bidirectional motility of kinesin-5 motor proteins: structural determinants, cumulative functions and
physiological roles. Cellular and Molecular Life Sciences 75(10):1757-1771 https://link.springer.com/article/10.1007%2Fs00018-017-2523-z
A. Goldstein, N. Siegler, D. Goldman, H. Judah, E. Valk, M. Kõivomägi, M. Loog, and L. Gheber (2017) Three Cdk1 sites in the kinesin-5 Cin8 catalytic domain coordinate motor localization and activity during anaphase. Cellular and Molecular Life Sciences 74(18):3395-3412 https://link.springer.com/article/10.1007%2Fs00018-017-2523-z
O. Shapira, A. Goldstein, J. Al-Bassam, L. Gheber (2017) A potential physiological role for bi-directional motility and motor clustering of mitotic kinesin-5 Cin8 in yeast mitosis Journal of Cell Science 130(4): 725-734 Featured in an “In this issue" minireview. https://journals.biologists.com/jcs/article/130/4/725/56626/A-potential-physiological-role-for-bi-directional
O. Shapira and L. Gheber (2016) Motile properties of the bi-directional kinesin-5 Cin8 are affected by phosphorylation in its motor domain Scientific Reports 6:25597 https://www.nature.com/articles/srep25597
A. Düselder, V. Fridman, C. Thiede, A. Wiesbaum, A. Goldstein, D. R. Klopfenstein, O. Zaitseva, M. E. Janson, L. Gheber, and C.F. Schmidt (2015) Deletion of the Tail Domain of the Kinesin-5 Cin8 affects its directionality Journal of Biological Chemistry 290(27):16841-50 https://www.jbc.org/article/S0021-9258(20)40239-X/fulltext
H. Asraf, R. Avunie-Masala, M. Hershfinkel and L. Gheber (2015) Mitotic slippage and expression of survivin are linked to differential sensitivity of human cancer cell- lines to the kinesin-5 inhibitor monastrol PLOS ONE 10(6):e0129255 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129255
V. Fridman, A. Gerson-Gurwitz, O. Shapira, N. Movshovich, S. Lakämper, C.F. Schmidt, and L. Gheber (2013) Kinesin-5 Kip1 is a bi-directional motor that stabilizes microtubules and tracks their plus-ends in vivo. Journal of Cell Science 126(18):4147-59. Featured in an “In Brief" minireview. https://journals.biologists.com/jcs/article/126/18/4147/53820/Kinesin-5-Kip1-is-a-bi-directional-motor-that
C. Thiede, V. Fridman, A. Gerson-Gurwitz, L. Gheber and C. F. Schmidt (2012) Regulation of bi-directional movement of single kinesin-5 Cin8 molecules. BioArchitecture 2, 70-74. https://www.tandfonline.com/doi/full/10.4161/bioa.20395
A. Gerson-Gurwitz, C. Thiede, N. Movshovich, V. Fridman, M. Podolskaya, T. Danieli, S. Lakämper, D.R. Klopfenstein, C.F. Schmidt and L. Gheber (2011) Directionality of individual kinesin-5 Cin8 motors is modulated by loop 8, ionic strength and microtubule geometry. EMBO Journal 18;30(24):4942-54. https://www.embopress.org/doi/full/10.1038/emboj.2011.403
R. Avunie-Masala, N. Movshovich, Y. Nissenkorn, A. Gerson-Gurwitz, V. Fridman, M. Kõivomägi, M. Loog, M.A. Hoyt, A. Zaritsky and L. Gheber (2011) Phospho- regulation of Kinesin-5 function during anaphase spindle elongation. Journal of Cell Science 15;124(6):873-8. https://journals.biologists.com/jcs/article/124/6/873/32164/Phospho-regulation-of-kinesin-5-during-anaphase
V. Fridman, A. Gerson-Gurwitz, N. Movshovich, M. Kupiec and L. Gheber. (2009) Midzone organization restricts interpolar microtubule plus-end dynamics during spindle elongation. EMBO Reports 10(4):387-93. https://www.embopress.org/doi/full/10.1038/embor.2009.7
A. Gerson-Gurwitz, N. Movshovich, K. Moyal, R. Avunie-Masala, V. Fridman, MA. Hoyt, B. Katz and L. Gheber. (2009) Mid-anaphase arrest in cells eliminated for the function of Cin8 and dynein. Cellular and Molecular Life Sciences 66(2):301-13. https://link.springer.com/article/10.1007%2Fs00018-008-8479-2
N. Movshovich, V. Fridman, A. Gerson-Gurwitz, I. Schumacher, I. Gertsberg, A. Fich, MA. Hoyt, B. Katz and L. Gheber. (2008) Slk19-dependent mid-anaphase pause in kinesin-5 mutated cells. Journal of Cell Science 121:2529-39. https://journals.biologists.com/jcs/article/121/15/2529/30153/Slk19-dependent-mid-anaphase-pause-in-kinesin-5
E.R. Hildebrandt, L. Gheber, T. Kingsbury and M.A. Hoyt (2006), Homotetrameric form of Cin8p, an S. cerevisiae kinesin-5 motor, is essential for its in vivo function. Journal of Biological Chemistry 281:26004-26013. https://www.jbc.org/article/S0021-9258(19)35128-2/fulltext
A. Mermelshtein, A. Gerson, S. Walfisch, B. Delgado, G. Shechter-Maor, J. Delgado, A. Fich and L. Gheber. (2005) Expression of D-type cyclins in colon cancer and in cell-lines from colon carcinomas. British Journal of Cancer 93(3):338-45. https://www.nature.com/articles/6602709
I. Leizerman, R. Avunie-Masala, M. Elkabets, A. Fich and L. Gheber (2004) Differential effect of monastrol in two human cell lines. Cellular and Molecular Life Sciences 61(16):2060-70. https://link.springer.com/article/10.1007%2Fs00018-004-4074-3
F. R. Cottingham, L. Gheber, D. L. Miller and M. Andrew Hoyt (2000) Novel roles for Saccharomyces cerevisiae mitotic spindle motors. Journal of Cell Biology 147:335-349. https://rupress.org/jcb/article/147/2/335/20077/Novel-Roles-for-Saccharomyces-cerevisiae-Mitotic
L. Gheber, S.C. Kuo and M.A. Hoyt. (1999) Motile properties of the kinesin- related Cin8p spindle motor extracted from S. cerevisiae cells. Journal of Biological Chemistry 274:9564-9572. https://www.jbc.org/article/S0021-9258(19)87291-5/fulltext
L. Gheber, A. Korngreen and Z. Priel. (1998) Effect of viscosity on metachrony in mucus propelling cilia. Cell Motility and the Cytoskeleton 39:9-20. https://pubmed.ncbi.nlm.nih.gov/?term=gheber%20L&sort=date&page=7
L. Gheber and Z. Priel. (1997) Extraction of cilium beat parameters by the combined application of photoelectric measurement and computer simulation. Biophysical Journal 72:449-462. https://pubmed.ncbi.nlm.nih.gov/?term=gheber%20L&sort=date&page=7
A. Tarasiuk, M. Bar-Shimon, L. Gheber, A. Korngreen and Z. Priel. (1995) Extracellular ATP -induced hyperpolarization and motility stimulation of ciliary cells. Biophysical Journal 68:1163-1169. https://pubmed.ncbi.nlm.nih.gov/?term=gheber%20L&sort=date&page=7
L. Gheber, Z. PrielC, C. AflaloC and V. Shoshan-BarmatzPI. (1995) Extracellular ATP binding proteins as potential receptors in mucociliary epithelium: characterization using [32P]3'-O-(4-Benzoyl)benzoyl ATP, a photoaffinity label. Journal of Membrane Biology 147:83-93. https://pubmed.ncbi.nlm.nih.gov/?term=gheber%20L&sort=date&page=7
L. Gheber and Z. Priel. (1994) Metachronal activity of cultured mucociliary epithelium under normal and stimulated conditions. Cell Motility and the Cytoskeleton 28:333-345. https://pubmed.ncbi.nlm.nih.gov/?term=gheber%20L&sort=date&page=7
Z. Weiss, L. Gheber, V. Shoshan-Barmatz and Z. Priel. (1992) Possible mechanism of ciliary stimulation by extracellular ATP: Involvement of calcium dependent potassium channels and extracellular Ca2+. Journal of Membrane Biology 127:185-193. https://pubmed.ncbi.nlm.nih.gov/?term=gheber%20L&sort=date&page=7
L. Gheber and Z. Priel. (1990) On metachronism in ciliary systems: a model describing the dependence of the metachronal wave properties on the intrinsic ciliary parameters. Cell Motility and the Cytoskeleton 16:167-181. https://pubmed.ncbi.nlm.nih.gov/?term=gheber%20L&sort=date&page=7
L. Gheber and Z. Priel. (1990) Ciliary activity under normal conditions and under viscous load. Biorheology 27:547-557. https://pubmed.ncbi.nlm.nih.gov/?term=gheber%20L&sort=date&page=7
L. Gheber and Z. Priel. (1989) Synchronization between beating cilia. Biophysical Journal 55:183-191. https://pubmed.ncbi.nlm.nih.gov/?term=gheber%20L&sort=date&page=7
