הרצאתו של פרופ' אוהד מדליה מהמחלקה לביוכימיה באוניברסיטת ציריך ,שוויץ:
תובנות על המבנה והמכניקה של המעטפת הגרעינית של התא ע"י שיטות היברידיות, במסגרת בימת דיקן הפקולטה למדעי הטבע
Insight into the structure and mechanics of the cell’s nuclear envelope by hybrid approaches
Professor Ohad Medalia
Department of Biochemistry, University of Zurich, Zurich, Switzerland.
The nuclear envelope is mostly composed of double nuclear membranes that provide a physical barrier that is perforated by the nuclear pore complex (NPC), an enormous macromolecular complex that provide the sole gateways in and out of the nucleus. Attached to the nuclear phase of the nuclear membrane, the nuclear lamina provides a layer of filamentous scaffolding that is anchored to the membrane as well as to the NPCs. Mostly composed of lamins, the nuclear lamina is found ubiquitously in differentiated cells. Using variety of modalities, such as protein design, atomic force microscopy, molecular dynamics (MD) simulations, quotative fluorescence and cryo-electron microscopy, we provided unprecedented understanding of the remarkable structure and mechanical properties of nuclear Lamins and the NPC.
In this seminar I will discuss the technological advances and biological results that revise our view on the nuclear envelope of cells. In particular, the effect of disease associated mutations in lamins and the effect of cell integrity on the nuclear structure will be discussed.
Ohad Medalia is a Professor of Biochemistry at the University of Zurich, Switzerland. He is renowned for his pioneering work on the use of cryo-electron microscopy as a tool for in situ structural analysis, and for his ground-breaking structural research on the nuclear envelope and the cell cytoskeleton. He is a former researcher of BGU (life sciences department) and collaborates with BGU researchers.