Dear members, students and guests of
the Zlotowski center for Neuroscience,
You are cordially invited to a Special
seminar
Due Thursday, September 7th, 15:00
Venue: Caroline House, room 204
(Faculty of Health Sciences)
"Incubation
of drug craving after voluntary abstinence: behavior and circuit
mechanisms"
Presented by
Dr.
Yavin Shaham
(Editor in the Journal of Neuroscience)
Branch Chief, Intramural Research Program, NIDA-NIH
https://irp.drugabuse.gov/Shahamlab.php
Lecture summary: In previous studies, we and others have used a rat model of drug relapse
and craving to demonstrate time-dependent increases in drug seeking after
experimenter-imposed (forced) abstinence from several drugs of abuse (heroin,
cocaine, methamphetamine, nicotine), a phenomenon we termed incubation of drug
craving (Grimm et al. Nature, 2001; Pickens et al. TINS, 2011). In these
studies, the rats were removed from their drug self-administration environment
during extended periods of forced abstinence. More recently, we have
established a rat model in which we observe incubation of drug craving after
extended periods of voluntary abstinence in the drug environment. Voluntary
abstinence is achieved using a mutually exclusive discrete choice procedure in which food-sated
male and female rats with prior extended history of intravenous methamphetamine
or heroin self-administaration can choose every day (20 trials per day) between
the palatable food and the drug. In this
lecture, I will present our initial behavioral, pharmacological, and brain
circuit characterization of incubation of drug craving after voluntary
abstinence. I will also introduce a novel relapse model in which voluntary
abstinence is achieved by providing the rats an alternative social reward.
Biography: Yavin Shaham received his BS and MA from the Hebrew U, Jerusalem,
and his PhD from the Uniformed Services University of the Health Sciences,
Bethesda, MD. His postdoctoral training was at Concordia U, Montreal, in the
laboratory of Dr. Jane Stewart. Prior to joining the NIDA Intramural Research
Program as a tenure-track investigator, he was an investigator at the Addiction
Research Center in Toronto. He is currently a tenured Branch Chief and a Senior
Investigator. His major awards include the NIDA Director’s Award of Merit
(2001), the Society of Neuroscience Jacob Waletzky award for innovative
research in drug and alcohol addiction (2006), the NARSAD Distinguished Investigator Grant Award (2016),
and the European Behavioral Pharmacology Society Distinguished Achievement
Award (2017). He has published over 190 empirical
papers, reviews, and commentaries, and his papers were cited over 22,500 times
(h-factor: 82; Google Scholar). He currently serves as a Senior Editor
for The Journal of Neuroscience and as a Handling (Reviewing) Editor of Neuropsychopharmacology.
He is also an editorial board member of Biological Psychiatry, Psychopharmacology,
and Addiction Biology. His group currently investigates mechanisms of
relapse to heroin, oxycodone, cocaine, and methamphetamine, as assessed in rat
models developed in his lab. Most recently, his lab has developed an
operant aggression reward model to study mechanisms of relapse to aggressive
behavior in mice.
Recent papers and reviews relevant to the lecture
Caprioli
D, Venniro M, Zeric T, Li, X, Adhikary S, Madangopal
R, Marchant
NJ, Lucantonio F, Schoenbaum G, Bossert JM,
Shaham Y (2015) Effect of the novel
positive allosteric modulator of mGluR2 AZD8529 on incubation of
methamphetamine craving after prolonged voluntary abstinence in a rat model. Biological
Psychiatry 78:463-473
Venniro M, Caprioli D, Shaham Y (2016)
Animal models of drug relapse: from drug priming to incubation of drug craving
after voluntary abstinence Progress in Brain Research 224:25-52
Heilig M, Epstein DE, Nader M, Shaham Y
(2016) It is time to connect: Addiction neuroscience and social context. Nature
Review Neuroscience 17:592-599
Caprioli D, Venniro M, Zhang M,
Bossert JM, Warren BL, Hope BT, Shaham Y (2017) Role of dorsomedial striatum
neuronal ensembles in incubation of methamphetamine craving after voluntary
abstinence. The Journal of Neuroscience 37:1014-1027
Venniro M, Zhang M, Shaham Y, Caprioli
D (2017) Incubation of methamphetamine but not heroin craving after voluntary
abstinence in male and female rats. Neuropsychopharmacology 42:1126-1135
Venniro M, Caprioli D, Zhang M,
Whitaker LR, Zhang S, Wang HL, Warren BL, Cifani C, Marchant NJ, Yizhar O,
Harvey BL, Bossert JM, Chiamulera C, Morales M, Shaham Y. The anterior insular
cortex→central amygdala glutamatergic pathway is critical to
relapse after contingency management. Neuron (revision under review)
Venniro M, Zhang M, Caprioli D,
Morales M, Shaham Y. Social-based voluntary abstinence prevents the emergence
of incubation of drug craving. SFN poster 2017
Those of you who wish to meet the
lecturer can write to azangen@bgu.ac.il
See you all,
Boomy Zangen, Special Seminar coordinator
Prof. Abraham Zangen
