Stem Cells generate new cells needed in our bodies for healthy life, and further regenerate damaged tissues upon insults. How adult stem cells are able to self-renew and sustain multipotency is largely unknown. Now, study of hematopoietic stem cells (HSCs) aims to discover basic biological mechanisms that enable their amazing function – as these cells already saves thousands of lives by bone marrow transplant. Revealing HSC's regulation will also enable us to control the source of the immune system.
Specific interests, with specific collaboration interests highlighted:
1. Direct reprogramming of blood-cells into HSCs. We had identified key transcription factors, doing mechanistic study and aiming to improve efficiency and TRANSLATE FOR HUMAN.
2. Tailor-made Leukemia models in immune-competent mice. Made several and can do probably any model of interest that will HELP TO DEVELOP NEW TREATMENTS.
3. High-powered Approach for Multiple-myeloma Evaluation Research: aiming for personalized precision approach for Multiple-myeloma. Collaborative study with Angel Porgador and Dr. Ori Ruvio (Soroka) to gain insight on multiple-myeloma single-cell response to combinatorial-therapies.
4. HSCs within the immune response: stem cells function as part of the immune system. We have novel abilities to identify and follow HSCs also under activation-state, interested in HSCs ON INTERESTING IMMUNOLOGICAL MODELS, AND HUMAN CHRONIC DISEASES (especially MDS).
5. Whole-trascriptome splicing in HSCs. We had recently mapped the splicing in mouse HSCs and interested in the MECHANISM(S) and FUNCTION of SPLICING IN ADULT STEM CELLs.
6. Rejuvenation of the immune system from its stem-cells. HSCs generate all immune cells, but as we age we accumulate “old" leukocytes. Depletion of “aged" immune cells may provoke REJUVENATION OF THE IMMUNE SYSTEM.