A team of BGU life sciences researchers recently engineered a new super enzyme that can detect glucose in the bloodstream much more precisely – an important capability for those with Diabetes. People with Diabetes must continually check their glucose levels to make sure their insulin levels do not tip too low or too high. The enzyme detects glucose but is not sensitive to other commonly found substances in the bloodstream such as vitamins or pain killers, which often mislead glucose measurements.
Their findings were just published in the Journal of the American Chemical Society.
3D model of FAD−GDH−MCD (FGM)
In addition to much clearer readings, the enzyme produces much quicker responses, thus lowering the test-taking time. Standard tests have generally relied on a protein to cause a chemical reaction and oxidize the glucose and turn it into a different molecule. That process sends electrons to an electrode and the current is interpreted as the glucose level. However, other substances in the blood can also raise the electrical current level and provide inaccurate readings. Now, the enzyme selectively oxidizes glucose and offers a much more accurate reading.
The research was conducted by Profs. Lital Alfonta and Raz Zarivach along with Alfonta's students Itai Algov and Jennifer Grushka from the Department of Life Sciences at BGU.
The study was funded by an Israel Science Foundation Grant and is related to consulting work done for SmartZyme Innovations LTD.