Understanding the mechanisms involved in the maintenance of homeostatic immune responses as well as those that have gone awry in disease states, poses a significant challenge. At the NIBN, a robust platform technology called “direct evolution" is being used to generate superior, soluble anti-inflammatory proteins to treat auto-immune diseases such as psoriasis, rheumatoid arthritis (RA), inflammatory bowel disease (IBD) and asthma. Additionally, this group's efforts include understanding how chronic stress is associated with increased susceptibility to auto-immune disease. Other activities include the role of adipose tissue dysfunction in obesity and associated co-morbidities as well as the relationship between type-2 diabetes, suppression of mitochondrial turnover, -cell dysfunction and apoptosis



 Group members