​Ph.D. Senior Lecturer

Comparative Immunology Laboratory

Benyamin Rosental

Contac​t:

French Associates Institute for Agriculture and Biotechnology of Drylands
Jacob Blaustein Institute for Desert Research
Ben Gurion University of the Negev, Sede-Boqer Campus, 84990, Israel

Telephone: +972-8-6596745
Fax: +972-8-6596752

E-mail: rosentab@post.bgu.ac.il

​​ 

Education and Academic positions:


  • Since October 2018: Senior Lecturer (Assistant Professor), French Associates Institute for Agriculture and Biotechnology of Drylands, Ben Gurion University of the Negev.
  • April 2013- September 2018: Postdoctoral researcher, Stanford University, School of Medicine, Stem cell Institute at the Irving Weissman Laboratory.
  • October 2012- March 2013: Short term Postdoctoral researcher fellow, Ben Gurion University, Faculty of Health Sciences.
  • 2007-2012: PhD studies, Ben Gurion University, Faculty of Health Sciences in the Department of Microbiology and Immunology. Supervised by Prof. Angel Porgador.
  • 2010: M.Med.Sc. Graduated summa cum laude.
  • 2004-2007: B.Sc. Department of Life Sciences, Ben Gurion University. Graduated summa cum laude.

 

Research background and interest:

I conducted my postdoctoral research at Stanford University, Institute of Stem Cells, School of Medicine, and Stanford Hopkins Marine Station. My PhD research was in cancer, viral, and pregnancy immunology. During my Postdoctoral research I was working on immune system histocompatibility and stem cell transplantation using a unique aquatic protochordate model.

The comparative immunology laboratory at Ben Gurion University that we are establishing will focus on several research directions:

i) Studying immune mechanisms of cellular recognition and histocompatibility, for translation to medical application as well as aquaculture.

ii) Studying and characterizing immune and stem cells for aquatic organisms, for immune modulation and stem cell transplantation.

iii) Studying, modifying, and developing vaccines for aquaculture. Including the use of vaccination vectors with the existing research at the Jacob Blaustein Institutes for Desert Research such as plant plastid and/or microalgae.

 

 

Publications:​

  1. Rosental B, Kowarsky MA, Seita J, Corey DM, Ishizuka KJ, Palmeri KJ, Chen SY, Sinha R, Okomoto J, Mantalas G, Manni L, Raveh T, Clarke DN, Tsai JM, Newman AM, Neff NF, Nolan GP, Quake SR, Weissman IL, and Voskoboynik A. “Complex mammalian-like haematopoietic system found in a colonial chordate". Nature in press. (2018)
    On bioXriv: https://www.biorxiv.org/content/early/2017/12/26/206318.
  2. Barkal AA, Weiskopf K, Kao KS, Gordon SR, Rosental B, Yiu YY, George BM, Markovic M, Ring NG, Tsai JM, McKenna KM, Ho PY, Cheng RZ, Chen JY, Barkal LJ, Ring AM, Weissman IL, Maute RL. “Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy." Nature Immunology.  2018, 19(1):76-84., doi: 10.1038/s41590-017-0004-z.
  3. *Pavlov V, *Rosental B, Rowbotham I, Hansen AF, and Block BA. “Hydraulic control of tuna fins: a role for the lymphatic system in locomotion." Science. 2017, 21;357(6348):310-314.
    *(Equal contributor to first author) got the cover of Science.
  4. Rosental B, Kozhekbaeva Z, Fernhoff N, Tsai J, and Traylor-Knowles N. “Coral cell separation and isolation by Fluorescence-Activated Cell Sorting". BMC Cell Biology. 2017, 29;18(1):30.
    This article was chosen to be featured the BMC Cell Biology.
  5. Shemesh A, Kugel S, Steiner N, Yezersky M, Tirosh D, Edri A, Telsh O, Rosental B, Sheiner E, Rubin E, Campbell K, and Porgador A. "NKp44 and NKp30 splice variant profiles in decidua and tumor tissues: a comparative viewpoint." E-publication ahead of print Oncotarget.2016, DOI: 10.18632/oncotarget.12292.
  6. *Corey DM, *Rosental B, Kowarsky MA, Sinha R, Ishizuka KJ, Palmeri KJ, Quake SR, Voskoboynik A, and Weissman IL. “Developmental cell death programs license cytotoxic cells to eliminate histocompatible partners" Proceedings of the National Academy of Sciences (PNAS). 2016, 113(23):6520-5.
    *(Equal contributor to first author)
  7. Shemesh A, Brusilovsky M, Hadad U, Telsh O, Edri A, Campbell K, Rosental B, and Porgador A. “Poor survival in Acute Myeloid Leukemia is associated with dominant expression of the ITIM-bearing NKp44 splice variant." Oncotarget, 2016, 31;7(22):32933-45.
  8. Rosental B, Shemesh A, Mendelson M, Ryger L, Kodman Y, Levy J, Porgador A, and Broides A. “Evaluation of purified Natural Killer cell- function in Familial Hemophagocytic Lymphohistiocytosis". LymphoSign Journal, 2015, 2(4): 207-212, 10.
  9. Shemesh A, Tirosh D, Sheiner E, Tirosh NB, Brusilovsky M, Segev R, Rosental B, and Porgador A. “First Trimester Pregnancy Loss and the Expression of NKp30 Isoforms in Maternal Blood and Placental Tissue". Frontiers in Immunology, 2014, 1;6:189.
  10. Tal Y, Yaakobi S, Horovitz-Fried M, Safyon E, Rosental B, Porgador A, and Cohen C. “An NCR1-based chimeric antigen receptor endows T-cells with multiple anti-tumor specificities". Oncotarget. 2014 April; 5.  
  11. Brusilovsky M, Cordoba M, Rosental B, Hershkovitz O, Andrake M, Pecherskaya A, Einarson M, Zhou Y, Braiman A, Campbell K, and Porgador A. “Genome-wide siRNA screen reveals a new cellular partner of KIR2DL4: heparan sulfate directly modulates KIR2DL4-mediated responses." Journal of Immunology. 2013, 15;191(10):5256-67.
  12. Rosental B, Hadad U, Sinay R, Braiman A, Porgador A, and Pollack Y. “Dual fluorescent labeling of the human malaria causing agent Plasmodium Falciparum for the analysis of the ABC type transporter pfmdr2." Malaria Journal. 2012, 8;11(1):371.
  13. Brusilovsky M, Rosental B, Yossef R, Appel M, and Porgador A. “Human NK cell recognition of target cells in the prism of natural cytotoxicity receptors and their ligands." Journal of Immunotoxi cology. 2012 July; 9(3):267-74.        
  14. Rosental B, Hadad U, Brusilovsky M, Campbell K, and Porgador A. “A novel mechanism for evasion of NK response by cancer cells: interaction of NKp44 and Proliferating Cell Nuclear Antigen." OncoImmunology. 2012, 1(4):572-574.
  15. Mendelson M, Yossef R, Appel M, Zilka A, Hadad U, Afergan F, Rosental B, Engel S, Braiman A and Porgador A. “Dimerization of NKp46 receptor is essential for NKp46-mediated lysis: characterization of the dimerization site by epitope mapping." Journal of Immunology. 2012, 188 (12):6165-74.
  16. *Edri-Brami M, *Rosental B, Hayoun D, Welt M, Buskila H, Wirguin I, Nefussy B, Drori V, Porgador A, and Lichtenstein R. “Glycans in Sera of Amyotrophic Lateral Sclerosis Patients and Their Involvement in Killing Neuronal Cells". PlosONE. 2012, 7(5):e35772.   
    *(Equal contributor to first author)
  17. Rosental B, Appel M, Yossef R, Hadad U, Brusilovsky M, and Porgador A. “The effect of chemotherapy/radiotherapy on cancerous pattern recognition by NK cells". Current Medicinal Chemistry, 2012, 19(12):1780-91.
    • This article was chosen to be featured in Global Medical Discovery Series.
  18. Yossef R, Rosental B, Appel M, Hershkovitz O, and Porgador A. “Upregulation of MHC Class I Expression Following Dengue Virus Infection: The Mechanism at the Promoter Level." Expert Review of Anti-infective Therapy, 2012, 10(3):285-7.
  19. Rosental B, Brusilovsky M, Hadad U, Oz D, Appel M, Afergan F, Yossef R, Rosenberg L, Aharoni A, Cerwenka A, Campbell K, Braiman A, and Porgador A. “Proliferating Cell Nuclear Antigen is a novel inhibitory ligand for the natural cytotoxicity receptor NKp44." Journal of Immunology, 2011, 187(11):5693-702.     
    • This article was chosen to be featured in MDLinx.
  20. Zilka A, Mendelson M, Rosental B, Hershkovitz O, and Porgador A. Generating NK cell receptor-Fc chimera proteins from 293T cells and considerations of appropriate glycosylation. Methods Molecular Biology. 2010, 612: 275-83.
  21. *Hershkovitz O, *Rosental B, Rosenberg L, Navarro-Sanchez M, Jivov S, Zilka A, Gershoni-Yahalom O, Brient-Litzler E, Bedouelle H, Ho J, Campbell K, Rager-Zisman B, Desprès P, and Porgador A. “NKp44 receptor mediates interaction of the envelope glycoproteins from the West-Nile and dengue viruses with Natural Killer cells". Journal of Immunology, 2009, 183: 2610–2621.      
    *(Equal contributor to first author)
  22. *Hecht ML, *Rosental B, Horlacher T, Hershkovitz O, De Paz JL, Noti C, Schauer S, Porgador A, and Seeberger PH. “Natural cytotoxicity receptors NKp30, NKp44 and NKp46 bind to different heparan sulfate/heparin sequences". Journal of Proteome Research, 2009, 8(2):712-20. 
    *(Equal contributor to first author)​